The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

We identify a role for the GDI-like solubilizing factor (GSF) PDEδ in modulating signalling through Ras family G proteins by sustaining their dynamic distribution in cellular membranes. We show that the GDI-like pocket of PDEδ binds and solubilizes farnesylated Ras proteins, thereby enhancing their...

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Veröffentlicht in:	Nature cell biology 2012-02, Vol.14 (2), p.148-158
Hauptverfasser:	Chandra, Anchal, Grecco, Hernán E., Pisupati, Venkat, Perera, David, Cassidy, Liam, Skoulidis, Ferdinandos, Ismail, Shehab A., Hedberg, Christian, Hanzal-Bayer, Michael, Venkitaraman, Ashok R., Wittinghofer, Alfred, Bastiaens, Philippe I. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological transport Biomedical and Life Sciences Blotting, Western Cancer Research Cell Biology Cell Line Cell Membrane - metabolism Cellular signal transduction Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism Developmental Biology Fluorescence Recovery After Photobleaching Fluorescence Resonance Energy Transfer G proteins Genetic aspects Golgi Apparatus - metabolism Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Guanine Nucleotide Dissociation Inhibitors - genetics Guanine Nucleotide Dissociation Inhibitors - metabolism Hep G2 Cells Humans Intracellular Membranes - metabolism Life Sciences Lipoylation Microscopy, Confocal Molecular Sequence Data Physiological aspects Prenylation Protein Binding ras Proteins - genetics ras Proteins - metabolism RNA Interference Signal Transduction Stem Cells
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