Hypoglycemic Health Benefits of d-Psicose
Diabetes is an emerging health problem worldwide. The incidence of type 2 diabetes has dramatically increased and is expected to increase more rapidly in the future. Most patients with type 2 diabetes suffer from obesity and diabetes-related complications, including cardiovascular disease and hepati...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2012-02, Vol.60 (4), p.863-869 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Chung, Min-Yu Oh, Deok-Kun Lee, Ki Won |
| description | Diabetes is an emerging health problem worldwide. The incidence of type 2 diabetes has dramatically increased and is expected to increase more rapidly in the future. Most patients with type 2 diabetes suffer from obesity and diabetes-related complications, including cardiovascular disease and hepatic steatosis. It has been proposed that simple sugar consumption is one of the major risk factors in the development of diabetes. Hence, the replacement of sugars with a low glycemic response would be an effective strategy to prevent type 2 diabetes. Accumulating evidence demonstrates that d-psicose, which has 70% the sweetness of sucrose and no calories, is a functional sugar exerting several health benefits preventing the development of diabetes. Although d-psicose presents in small amounts in natural products, a recent new technique using biocatalyst sources enables large-scale d-psicose production. More importantly, several clinical and animal studies demonstrated that d-psicose has hypoglycemic, hypolipidemic, and antioxidant activities, which make it an ideal candidate for preventing diabetes and related health concerns. This review will summarize the protective effects of d-psicose against type 2 diabetes and its complications, suggesting its potential benefits as a sucrose substitute. |
| doi_str_mv | 10.1021/jf204050w |
| format | Article |
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The incidence of type 2 diabetes has dramatically increased and is expected to increase more rapidly in the future. Most patients with type 2 diabetes suffer from obesity and diabetes-related complications, including cardiovascular disease and hepatic steatosis. It has been proposed that simple sugar consumption is one of the major risk factors in the development of diabetes. Hence, the replacement of sugars with a low glycemic response would be an effective strategy to prevent type 2 diabetes. Accumulating evidence demonstrates that d-psicose, which has 70% the sweetness of sucrose and no calories, is a functional sugar exerting several health benefits preventing the development of diabetes. Although d-psicose presents in small amounts in natural products, a recent new technique using biocatalyst sources enables large-scale d-psicose production. More importantly, several clinical and animal studies demonstrated that d-psicose has hypoglycemic, hypolipidemic, and antioxidant activities, which make it an ideal candidate for preventing diabetes and related health concerns. This review will summarize the protective effects of d-psicose against type 2 diabetes and its complications, suggesting its potential benefits as a sucrose substitute.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf204050w</identifier><identifier>PMID: 22224918</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; antioxidant activity ; Antioxidants ; Biological and medical sciences ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - prevention & control ; fatty liver ; Food industries ; Fructose - administration & dosage ; Fructose - biosynthesis ; Fructose - pharmacokinetics ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypoglycemic Agents ; Hypolipidemic Agents ; new methods ; noninsulin-dependent diabetes mellitus ; obesity ; Obesity - complications ; patients ; psicose ; risk factors ; sucrose ; Sweetening Agents ; sweetness</subject><ispartof>Journal of agricultural and food chemistry, 2012-02, Vol.60 (4), p.863-869</ispartof><rights>Copyright © 2011 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a368t-d7c9098371b7dd352789578df2aa2c71222f6d351001c728552a96ac791fa10c3</citedby><cites>FETCH-LOGICAL-a368t-d7c9098371b7dd352789578df2aa2c71222f6d351001c728552a96ac791fa10c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf204050w$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf204050w$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25522788$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22224918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Min-Yu</creatorcontrib><creatorcontrib>Oh, Deok-Kun</creatorcontrib><creatorcontrib>Lee, Ki Won</creatorcontrib><title>Hypoglycemic Health Benefits of d-Psicose</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Diabetes is an emerging health problem worldwide. The incidence of type 2 diabetes has dramatically increased and is expected to increase more rapidly in the future. Most patients with type 2 diabetes suffer from obesity and diabetes-related complications, including cardiovascular disease and hepatic steatosis. It has been proposed that simple sugar consumption is one of the major risk factors in the development of diabetes. Hence, the replacement of sugars with a low glycemic response would be an effective strategy to prevent type 2 diabetes. Accumulating evidence demonstrates that d-psicose, which has 70% the sweetness of sucrose and no calories, is a functional sugar exerting several health benefits preventing the development of diabetes. Although d-psicose presents in small amounts in natural products, a recent new technique using biocatalyst sources enables large-scale d-psicose production. More importantly, several clinical and animal studies demonstrated that d-psicose has hypoglycemic, hypolipidemic, and antioxidant activities, which make it an ideal candidate for preventing diabetes and related health concerns. This review will summarize the protective effects of d-psicose against type 2 diabetes and its complications, suggesting its potential benefits as a sucrose substitute.</description><subject>Animals</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - prevention & control</subject><subject>fatty liver</subject><subject>Food industries</subject><subject>Fructose - administration & dosage</subject><subject>Fructose - biosynthesis</subject><subject>Fructose - pharmacokinetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hypoglycemic Agents</subject><subject>Hypolipidemic Agents</subject><subject>new methods</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>obesity</subject><subject>Obesity - complications</subject><subject>patients</subject><subject>psicose</subject><subject>risk factors</subject><subject>sucrose</subject><subject>Sweetening Agents</subject><subject>sweetness</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEFPwzAMhSMEYmNw4A9ALwjtULDTpUmOMAFDmgQS7FxlaTI6tc1oWqH9ezJtbBd8sWR_en5-hFwi3CFQvF9aCiNg8HNE-sgoxAxRHJM-hGUsWIo9cub9EgAE43BKejTUSKLok-FkvXKLcq1NVehoYlTZfkWPpja2aH3kbJTH777QzptzcmJV6c3Frg_I7PnpczyJp28vr-OHaaySVLRxzrUEKRKOc57nCaNcSMZFbqlSVHMMl20a5giAmlPBGFUyVZpLtApBJwNyu9VdNe67M77NqsJrU5aqNq7zmUSZMkgkC-RwS-rGed8Ym62aolLNOkPINsFk-2ACe7VT7eaVyffkXxIBuNkBymtV2kbVuvAHLvgMr2y46y1nlcvUognM7IMCjsI_yIKxg5LSPlu6rqlDXP9Y-gXYLnyE</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Chung, Min-Yu</creator><creator>Oh, Deok-Kun</creator><creator>Lee, Ki Won</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Hypoglycemic Health Benefits of d-Psicose</title><author>Chung, Min-Yu ; Oh, Deok-Kun ; Lee, Ki Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a368t-d7c9098371b7dd352789578df2aa2c71222f6d351001c728552a96ac791fa10c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - prevention & control</topic><topic>fatty liver</topic><topic>Food industries</topic><topic>Fructose - administration & dosage</topic><topic>Fructose - biosynthesis</topic><topic>Fructose - pharmacokinetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypoglycemic Agents</topic><topic>Hypolipidemic Agents</topic><topic>new methods</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>obesity</topic><topic>Obesity - complications</topic><topic>patients</topic><topic>psicose</topic><topic>risk factors</topic><topic>sucrose</topic><topic>Sweetening Agents</topic><topic>sweetness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Min-Yu</creatorcontrib><creatorcontrib>Oh, Deok-Kun</creatorcontrib><creatorcontrib>Lee, Ki Won</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Min-Yu</au><au>Oh, Deok-Kun</au><au>Lee, Ki Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoglycemic Health Benefits of d-Psicose</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. 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| subjects | Animals antioxidant activity Antioxidants Biological and medical sciences Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - prevention & control fatty liver Food industries Fructose - administration & dosage Fructose - biosynthesis Fructose - pharmacokinetics Fundamental and applied biological sciences. Psychology Humans Hypoglycemic Agents Hypolipidemic Agents new methods noninsulin-dependent diabetes mellitus obesity Obesity - complications patients psicose risk factors sucrose Sweetening Agents sweetness |
| title | Hypoglycemic Health Benefits of d-Psicose |
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