Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice
A possible teratogenicity of multi-wall carbon nanotube (MWCNT) was assessed using ICR mice. MWCNTs were suspended in 2% carboxymethyl cellulose and given intraperitoneally or intratracheally to pregnant ICR mice on day 9 of the gestation. All fetuses were removed from the uterus on day 18 of the g...
Gespeichert in:
| Veröffentlicht in: | Journal of toxicological sciences 2012/02/01, Vol.37(1), pp.81-89 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 89 |
|---|---|
| container_issue | 1 |
| container_start_page | 81 |
| container_title | Journal of toxicological sciences |
| container_volume | 37 |
| creator | Fujitani, Tomoko Ohyama, Ken-ichi Hirose, Akihiko Nishimura, Tetsuji Nakae, Dai Ogata, Akio |
| description | A possible teratogenicity of multi-wall carbon nanotube (MWCNT) was assessed using ICR mice. MWCNTs were suspended in 2% carboxymethyl cellulose and given intraperitoneally or intratracheally to pregnant ICR mice on day 9 of the gestation. All fetuses were removed from the uterus on day 18 of the gestation, and were examined for external and skeletal anomalies. In the intraperitoneal study, various types of malformation were observed in all MWCNT-treated groups (2, 3, 4 and 5 mg/kg body weight, intraperitoneal). In contrast, such malformations were observed in groups given 4 or 5 mg/kg body weight, but not in that treated with 3 mg/kg in the intratracheal study. In either study, the number of litters having fetuses with external malformation and that of litters having fetuses with skeletal malformations were both increased in proportion to the doses of MWCNT. The present results are the first to report that MWCNT possesses the teratogenicity at least under the present experimental conditions. Mechanism(s) to result such malformations is yet unclear and further experiment is necessary. |
| doi_str_mv | 10.2131/jts.37.81 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_919650109</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>919650109</sourcerecordid><originalsourceid>FETCH-LOGICAL-c653t-8f16fb2173daa62b26a11cd3f2d6bbff8ed89a555ea87ada52a842f0fe33b9b03</originalsourceid><addsrcrecordid>eNp90UtrVDEUwPEgih1HF34BueDCdnHHnJz7SDaiDD4KbQUZcRlOcpN6h_uoSS7Sb9_ItLNw0U2yyI8_nBzGXgPfCEB4v09xg-1GwhO2Ail5iUqqp2zFUcoSsOYn7EWMe85Fy-vqOTsRQiisAFfs484FSvO1m3rbp9ti9sW4DKkv_9IwFJaCmadiomlOi3HF6eWv7dXurOin4nz7oxh7616yZ56G6F7d32v288vn3fZbefH96_n200VpmxpTKT003ghosSNqhBENAdgOvegaY7yXrpOK6rp2JFvqqBYkK-G5d4hGGY5r9u7QvQnzn8XFpMc-WjcMNLl5iVqBamoOXGV5-qgEjpWEPL7I9O1_dD8vYcpzaKgaKaVSgFmdHZQNc4zBeX0T-pHCbU7pfwvQeQEaW52ra_bmvriY0XVH-fDjGXw4gH1MdO2OgELq7eAeUnA4JBwf7G8K2k14B-DzlXg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1468889913</pqid></control><display><type>article</type><title>Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Fujitani, Tomoko ; Ohyama, Ken-ichi ; Hirose, Akihiko ; Nishimura, Tetsuji ; Nakae, Dai ; Ogata, Akio</creator><creatorcontrib>Fujitani, Tomoko ; Ohyama, Ken-ichi ; Hirose, Akihiko ; Nishimura, Tetsuji ; Nakae, Dai ; Ogata, Akio</creatorcontrib><description>A possible teratogenicity of multi-wall carbon nanotube (MWCNT) was assessed using ICR mice. MWCNTs were suspended in 2% carboxymethyl cellulose and given intraperitoneally or intratracheally to pregnant ICR mice on day 9 of the gestation. All fetuses were removed from the uterus on day 18 of the gestation, and were examined for external and skeletal anomalies. In the intraperitoneal study, various types of malformation were observed in all MWCNT-treated groups (2, 3, 4 and 5 mg/kg body weight, intraperitoneal). In contrast, such malformations were observed in groups given 4 or 5 mg/kg body weight, but not in that treated with 3 mg/kg in the intratracheal study. In either study, the number of litters having fetuses with external malformation and that of litters having fetuses with skeletal malformations were both increased in proportion to the doses of MWCNT. The present results are the first to report that MWCNT possesses the teratogenicity at least under the present experimental conditions. Mechanism(s) to result such malformations is yet unclear and further experiment is necessary.</description><identifier>ISSN: 0388-1350</identifier><identifier>EISSN: 1880-3989</identifier><identifier>DOI: 10.2131/jts.37.81</identifier><identifier>PMID: 22293413</identifier><language>eng</language><publisher>Japan: The Japanese Society of Toxicology</publisher><subject>Abnormalities, Drug-Induced ; Administration, Inhalation ; Animals ; Body weight ; Bone and Bones - abnormalities ; Bone and Bones - drug effects ; Carbon ; Carboxymethylcellulose ; Female ; Fetuses ; Gestation ; Hazard identification ; Injections, Intraperitoneal ; Litter ; Male ; Mice ; Mice, Inbred ICR ; Multi-wall carbon nanotube ; Nanomaterial ; Nanotubes, Carbon - toxicity ; Pregnancy ; Teratogenicity ; Teratogens - toxicity ; Trachea ; Uterus</subject><ispartof>The Journal of Toxicological Sciences, 2012/02/01, Vol.37(1), pp.81-89</ispartof><rights>2012 The Japanese Society of Toxicology</rights><rights>Copyright Japan Science and Technology Agency 2012</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-8f16fb2173daa62b26a11cd3f2d6bbff8ed89a555ea87ada52a842f0fe33b9b03</citedby><cites>FETCH-LOGICAL-c653t-8f16fb2173daa62b26a11cd3f2d6bbff8ed89a555ea87ada52a842f0fe33b9b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22293413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujitani, Tomoko</creatorcontrib><creatorcontrib>Ohyama, Ken-ichi</creatorcontrib><creatorcontrib>Hirose, Akihiko</creatorcontrib><creatorcontrib>Nishimura, Tetsuji</creatorcontrib><creatorcontrib>Nakae, Dai</creatorcontrib><creatorcontrib>Ogata, Akio</creatorcontrib><title>Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice</title><title>Journal of toxicological sciences</title><addtitle>J Toxicol Sci</addtitle><description>A possible teratogenicity of multi-wall carbon nanotube (MWCNT) was assessed using ICR mice. MWCNTs were suspended in 2% carboxymethyl cellulose and given intraperitoneally or intratracheally to pregnant ICR mice on day 9 of the gestation. All fetuses were removed from the uterus on day 18 of the gestation, and were examined for external and skeletal anomalies. In the intraperitoneal study, various types of malformation were observed in all MWCNT-treated groups (2, 3, 4 and 5 mg/kg body weight, intraperitoneal). In contrast, such malformations were observed in groups given 4 or 5 mg/kg body weight, but not in that treated with 3 mg/kg in the intratracheal study. In either study, the number of litters having fetuses with external malformation and that of litters having fetuses with skeletal malformations were both increased in proportion to the doses of MWCNT. The present results are the first to report that MWCNT possesses the teratogenicity at least under the present experimental conditions. Mechanism(s) to result such malformations is yet unclear and further experiment is necessary.</description><subject>Abnormalities, Drug-Induced</subject><subject>Administration, Inhalation</subject><subject>Animals</subject><subject>Body weight</subject><subject>Bone and Bones - abnormalities</subject><subject>Bone and Bones - drug effects</subject><subject>Carbon</subject><subject>Carboxymethylcellulose</subject><subject>Female</subject><subject>Fetuses</subject><subject>Gestation</subject><subject>Hazard identification</subject><subject>Injections, Intraperitoneal</subject><subject>Litter</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Multi-wall carbon nanotube</subject><subject>Nanomaterial</subject><subject>Nanotubes, Carbon - toxicity</subject><subject>Pregnancy</subject><subject>Teratogenicity</subject><subject>Teratogens - toxicity</subject><subject>Trachea</subject><subject>Uterus</subject><issn>0388-1350</issn><issn>1880-3989</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90UtrVDEUwPEgih1HF34BueDCdnHHnJz7SDaiDD4KbQUZcRlOcpN6h_uoSS7Sb9_ItLNw0U2yyI8_nBzGXgPfCEB4v09xg-1GwhO2Ail5iUqqp2zFUcoSsOYn7EWMe85Fy-vqOTsRQiisAFfs484FSvO1m3rbp9ti9sW4DKkv_9IwFJaCmadiomlOi3HF6eWv7dXurOin4nz7oxh7616yZ56G6F7d32v288vn3fZbefH96_n200VpmxpTKT003ghosSNqhBENAdgOvegaY7yXrpOK6rp2JFvqqBYkK-G5d4hGGY5r9u7QvQnzn8XFpMc-WjcMNLl5iVqBamoOXGV5-qgEjpWEPL7I9O1_dD8vYcpzaKgaKaVSgFmdHZQNc4zBeX0T-pHCbU7pfwvQeQEaW52ra_bmvriY0XVH-fDjGXw4gH1MdO2OgELq7eAeUnA4JBwf7G8K2k14B-DzlXg</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Fujitani, Tomoko</creator><creator>Ohyama, Ken-ichi</creator><creator>Hirose, Akihiko</creator><creator>Nishimura, Tetsuji</creator><creator>Nakae, Dai</creator><creator>Ogata, Akio</creator><general>The Japanese Society of Toxicology</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice</title><author>Fujitani, Tomoko ; Ohyama, Ken-ichi ; Hirose, Akihiko ; Nishimura, Tetsuji ; Nakae, Dai ; Ogata, Akio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653t-8f16fb2173daa62b26a11cd3f2d6bbff8ed89a555ea87ada52a842f0fe33b9b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abnormalities, Drug-Induced</topic><topic>Administration, Inhalation</topic><topic>Animals</topic><topic>Body weight</topic><topic>Bone and Bones - abnormalities</topic><topic>Bone and Bones - drug effects</topic><topic>Carbon</topic><topic>Carboxymethylcellulose</topic><topic>Female</topic><topic>Fetuses</topic><topic>Gestation</topic><topic>Hazard identification</topic><topic>Injections, Intraperitoneal</topic><topic>Litter</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Multi-wall carbon nanotube</topic><topic>Nanomaterial</topic><topic>Nanotubes, Carbon - toxicity</topic><topic>Pregnancy</topic><topic>Teratogenicity</topic><topic>Teratogens - toxicity</topic><topic>Trachea</topic><topic>Uterus</topic><toplevel>online_resources</toplevel><creatorcontrib>Fujitani, Tomoko</creatorcontrib><creatorcontrib>Ohyama, Ken-ichi</creatorcontrib><creatorcontrib>Hirose, Akihiko</creatorcontrib><creatorcontrib>Nishimura, Tetsuji</creatorcontrib><creatorcontrib>Nakae, Dai</creatorcontrib><creatorcontrib>Ogata, Akio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of toxicological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujitani, Tomoko</au><au>Ohyama, Ken-ichi</au><au>Hirose, Akihiko</au><au>Nishimura, Tetsuji</au><au>Nakae, Dai</au><au>Ogata, Akio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice</atitle><jtitle>Journal of toxicological sciences</jtitle><addtitle>J Toxicol Sci</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>37</volume><issue>1</issue><spage>81</spage><epage>89</epage><pages>81-89</pages><issn>0388-1350</issn><eissn>1880-3989</eissn><abstract>A possible teratogenicity of multi-wall carbon nanotube (MWCNT) was assessed using ICR mice. MWCNTs were suspended in 2% carboxymethyl cellulose and given intraperitoneally or intratracheally to pregnant ICR mice on day 9 of the gestation. All fetuses were removed from the uterus on day 18 of the gestation, and were examined for external and skeletal anomalies. In the intraperitoneal study, various types of malformation were observed in all MWCNT-treated groups (2, 3, 4 and 5 mg/kg body weight, intraperitoneal). In contrast, such malformations were observed in groups given 4 or 5 mg/kg body weight, but not in that treated with 3 mg/kg in the intratracheal study. In either study, the number of litters having fetuses with external malformation and that of litters having fetuses with skeletal malformations were both increased in proportion to the doses of MWCNT. The present results are the first to report that MWCNT possesses the teratogenicity at least under the present experimental conditions. Mechanism(s) to result such malformations is yet unclear and further experiment is necessary.</abstract><cop>Japan</cop><pub>The Japanese Society of Toxicology</pub><pmid>22293413</pmid><doi>10.2131/jts.37.81</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0388-1350 |
| ispartof | The Journal of Toxicological Sciences, 2012/02/01, Vol.37(1), pp.81-89 |
| issn | 0388-1350 1880-3989 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_919650109 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Abnormalities, Drug-Induced Administration, Inhalation Animals Body weight Bone and Bones - abnormalities Bone and Bones - drug effects Carbon Carboxymethylcellulose Female Fetuses Gestation Hazard identification Injections, Intraperitoneal Litter Male Mice Mice, Inbred ICR Multi-wall carbon nanotube Nanomaterial Nanotubes, Carbon - toxicity Pregnancy Teratogenicity Teratogens - toxicity Trachea Uterus |
| title | Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T06%3A58%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Teratogenicity%20of%20multi-wall%20carbon%20nanotube%20(MWCNT)%20in%20ICR%20mice&rft.jtitle=Journal%20of%20toxicological%20sciences&rft.au=Fujitani,%20Tomoko&rft.date=2012-02-01&rft.volume=37&rft.issue=1&rft.spage=81&rft.epage=89&rft.pages=81-89&rft.issn=0388-1350&rft.eissn=1880-3989&rft_id=info:doi/10.2131/jts.37.81&rft_dat=%3Cproquest_cross%3E919650109%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1468889913&rft_id=info:pmid/22293413&rfr_iscdi=true |