Pharmacokinetics of ferulic acid and potential interactions with Honghua and clopidogrel in rats
Ferulic acid (FA), a compound isolated from herbs, has a big potential to be developed into a useful drug for the treatment of cardiovascular disease. Early estimation of potential drug interaction is critical for drug development. As a common Chinese herb and Western drug respectively, Honghua and...
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| Veröffentlicht in: | Journal of ethnopharmacology 2011-09, Vol.137 (1), p.562-567 |
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| creator | Li, Yanhong Liu, Changhui Zhang, Yinqing Mi, Suiqing Wang, Ningsheng |
| description | Ferulic acid (FA), a compound isolated from herbs, has a big potential to be developed into a useful drug for the treatment of cardiovascular disease. Early estimation of potential drug interaction is critical for drug development. As a common Chinese herb and Western drug respectively, Honghua and clopidogrel are often combined with FA-containing herbs to treat cardiovascular disease in clinical practice. This study aimed to investigate the pharmacokinetics of FA and potential interaction with Honghua and clopidogrel in rats.
The experiments were performed on following three groups: FA alone (10mg/kg, P.O.), combination of FA and Honghua (700mg/kg, P.O.), combination of FA and clopidogrel (7mg/kg, P.O.). Blood samples were collected before dosing and at 0, 2, 4, 7, 10, 15, 20, 30, 45, 60, 90, 120, 150, 180 and 210min after drug administration to determine the plasma drug concentration of FA.
FA was rapidly absorbed following oral administration with a mean time to peak plasma concentration (Tmax) of 0.03h. The corresponding maximum plasma concentration (Cmax) and the area under the concentration–time curve (AUC) were 8174.55ng/L and 2594.45hng/mL respectively. Coadministration of Honghua and clopidogrel resulted in a 63.5% and 79.7% increase in the AUC respectively. The Cmax of FA was significantly increased by coadministration with clopidogrel (74.3%, p |
| doi_str_mv | 10.1016/j.jep.2011.06.011 |
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The experiments were performed on following three groups: FA alone (10mg/kg, P.O.), combination of FA and Honghua (700mg/kg, P.O.), combination of FA and clopidogrel (7mg/kg, P.O.). Blood samples were collected before dosing and at 0, 2, 4, 7, 10, 15, 20, 30, 45, 60, 90, 120, 150, 180 and 210min after drug administration to determine the plasma drug concentration of FA.
FA was rapidly absorbed following oral administration with a mean time to peak plasma concentration (Tmax) of 0.03h. The corresponding maximum plasma concentration (Cmax) and the area under the concentration–time curve (AUC) were 8174.55ng/L and 2594.45hng/mL respectively. Coadministration of Honghua and clopidogrel resulted in a 63.5% and 79.7% increase in the AUC respectively. The Cmax of FA was significantly increased by coadministration with clopidogrel (74.3%, p<0.01). Moreover, the Tmax of FA when coadministered with Honghua or clopidogrel was 3 and 3.76 times slower than when administered alone. Other pharmacokinetic parameters estimated for FA were also altered by the coadministrations, but no statistically significant differences were observed.
FA was rapidly absorbed with a low bioavailability after a single oral administration. The pharmacokinetics profile of FA in rats was partly altered by the coadministration of FA with Honghua or clopidogrel.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2011.06.011</identifier><identifier>PMID: 21704146</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject><![CDATA[Administration, Oral ; Animals ; Biological and medical sciences ; Biological Availability ; Cardiovascular Agents - administration & dosage ; Cardiovascular Agents - blood ; Cardiovascular Agents - pharmacokinetics ; Carthamus tinctorius ; Clopidogrel ; Coumaric Acids - administration & dosage ; Coumaric Acids - blood ; Coumaric Acids - pharmacokinetics ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - pharmacokinetics ; Ferulic acid ; General pharmacology ; Herb-Drug Interactions ; Honghua ; Intestinal Absorption - drug effects ; Liquid chromatography ; Male ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacokinetics ; Pharmacology. Drug treatments ; Platelet Aggregation Inhibitors - administration & dosage ; Rats ; Rats, Sprague-Dawley ; Ticlopidine - administration & dosage ; Ticlopidine - analogs & derivatives]]></subject><ispartof>Journal of ethnopharmacology, 2011-09, Vol.137 (1), p.562-567</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-4d820305c879d1b762058a78a983c2af43ddba16f17a275707e3ec116f8c354d3</citedby><cites>FETCH-LOGICAL-c414t-4d820305c879d1b762058a78a983c2af43ddba16f17a275707e3ec116f8c354d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874111004284$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24505004$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21704146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yanhong</creatorcontrib><creatorcontrib>Liu, Changhui</creatorcontrib><creatorcontrib>Zhang, Yinqing</creatorcontrib><creatorcontrib>Mi, Suiqing</creatorcontrib><creatorcontrib>Wang, Ningsheng</creatorcontrib><title>Pharmacokinetics of ferulic acid and potential interactions with Honghua and clopidogrel in rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Ferulic acid (FA), a compound isolated from herbs, has a big potential to be developed into a useful drug for the treatment of cardiovascular disease. Early estimation of potential drug interaction is critical for drug development. As a common Chinese herb and Western drug respectively, Honghua and clopidogrel are often combined with FA-containing herbs to treat cardiovascular disease in clinical practice. This study aimed to investigate the pharmacokinetics of FA and potential interaction with Honghua and clopidogrel in rats.
The experiments were performed on following three groups: FA alone (10mg/kg, P.O.), combination of FA and Honghua (700mg/kg, P.O.), combination of FA and clopidogrel (7mg/kg, P.O.). Blood samples were collected before dosing and at 0, 2, 4, 7, 10, 15, 20, 30, 45, 60, 90, 120, 150, 180 and 210min after drug administration to determine the plasma drug concentration of FA.
FA was rapidly absorbed following oral administration with a mean time to peak plasma concentration (Tmax) of 0.03h. The corresponding maximum plasma concentration (Cmax) and the area under the concentration–time curve (AUC) were 8174.55ng/L and 2594.45hng/mL respectively. Coadministration of Honghua and clopidogrel resulted in a 63.5% and 79.7% increase in the AUC respectively. The Cmax of FA was significantly increased by coadministration with clopidogrel (74.3%, p<0.01). Moreover, the Tmax of FA when coadministered with Honghua or clopidogrel was 3 and 3.76 times slower than when administered alone. Other pharmacokinetic parameters estimated for FA were also altered by the coadministrations, but no statistically significant differences were observed.
FA was rapidly absorbed with a low bioavailability after a single oral administration. The pharmacokinetics profile of FA in rats was partly altered by the coadministration of FA with Honghua or clopidogrel.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Cardiovascular Agents - administration & dosage</subject><subject>Cardiovascular Agents - blood</subject><subject>Cardiovascular Agents - pharmacokinetics</subject><subject>Carthamus tinctorius</subject><subject>Clopidogrel</subject><subject>Coumaric Acids - administration & dosage</subject><subject>Coumaric Acids - blood</subject><subject>Coumaric Acids - pharmacokinetics</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - pharmacokinetics</subject><subject>Ferulic acid</subject><subject>General pharmacology</subject><subject>Herb-Drug Interactions</subject><subject>Honghua</subject><subject>Intestinal Absorption - drug effects</subject><subject>Liquid chromatography</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet Aggregation Inhibitors - administration & dosage</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Ticlopidine - administration & dosage</subject><subject>Ticlopidine - analogs & derivatives</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0cGO1DAMBuAIgdhh4QG4oF4Qpxa7TZtUnNAKWKSV4ADn4EncnQydpiQpiLenszPADU6Wos-_HFuIpwgVAnYv99We56oGxAq6ai33xAa1qkvVqua-2ECjdKmVxAvxKKU9ACiU8FBc1KhAouw24svHHcUD2fDVT5y9TUUYioHjMnpbkPWuoMkVc8g8ZU9j4afMkWz2YUrFD593xXWYbncL3Tk7htm7cBv5KItIOT0WDwYaEz8510vx-e2bT1fX5c2Hd--vXt-Udh0kl9LpGhporVa9w63qamg1KU29bmxNg2yc2xJ2Ayqq1--B4oYtrg_aNq10zaV4ccqdY_i2cMrm4JPlcaSJw5JMj73EtkX8r9Raain7-ijxJG0MKUUezBz9geJPg2COFzB7s17AHC9goDNwl_7snL5sD-z-dPxe-QqenwElS-MQabI-_XWyhRZAru7VyfG6te-eo0nW82TZ-cg2Gxf8P8b4BV8woxo</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Li, Yanhong</creator><creator>Liu, Changhui</creator><creator>Zhang, Yinqing</creator><creator>Mi, Suiqing</creator><creator>Wang, Ningsheng</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Pharmacokinetics of ferulic acid and potential interactions with Honghua and clopidogrel in rats</title><author>Li, Yanhong ; Liu, Changhui ; Zhang, Yinqing ; Mi, Suiqing ; Wang, Ningsheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-4d820305c879d1b762058a78a983c2af43ddba16f17a275707e3ec116f8c354d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Cardiovascular Agents - administration & dosage</topic><topic>Cardiovascular Agents - blood</topic><topic>Cardiovascular Agents - pharmacokinetics</topic><topic>Carthamus tinctorius</topic><topic>Clopidogrel</topic><topic>Coumaric Acids - administration & dosage</topic><topic>Coumaric Acids - blood</topic><topic>Coumaric Acids - pharmacokinetics</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Drugs, Chinese Herbal - pharmacokinetics</topic><topic>Ferulic acid</topic><topic>General pharmacology</topic><topic>Herb-Drug Interactions</topic><topic>Honghua</topic><topic>Intestinal Absorption - drug effects</topic><topic>Liquid chromatography</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet Aggregation Inhibitors - administration & dosage</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Ticlopidine - administration & dosage</topic><topic>Ticlopidine - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yanhong</creatorcontrib><creatorcontrib>Liu, Changhui</creatorcontrib><creatorcontrib>Zhang, Yinqing</creatorcontrib><creatorcontrib>Mi, Suiqing</creatorcontrib><creatorcontrib>Wang, Ningsheng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yanhong</au><au>Liu, Changhui</au><au>Zhang, Yinqing</au><au>Mi, Suiqing</au><au>Wang, Ningsheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of ferulic acid and potential interactions with Honghua and clopidogrel in rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>137</volume><issue>1</issue><spage>562</spage><epage>567</epage><pages>562-567</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Ferulic acid (FA), a compound isolated from herbs, has a big potential to be developed into a useful drug for the treatment of cardiovascular disease. Early estimation of potential drug interaction is critical for drug development. As a common Chinese herb and Western drug respectively, Honghua and clopidogrel are often combined with FA-containing herbs to treat cardiovascular disease in clinical practice. This study aimed to investigate the pharmacokinetics of FA and potential interaction with Honghua and clopidogrel in rats.
The experiments were performed on following three groups: FA alone (10mg/kg, P.O.), combination of FA and Honghua (700mg/kg, P.O.), combination of FA and clopidogrel (7mg/kg, P.O.). Blood samples were collected before dosing and at 0, 2, 4, 7, 10, 15, 20, 30, 45, 60, 90, 120, 150, 180 and 210min after drug administration to determine the plasma drug concentration of FA.
FA was rapidly absorbed following oral administration with a mean time to peak plasma concentration (Tmax) of 0.03h. The corresponding maximum plasma concentration (Cmax) and the area under the concentration–time curve (AUC) were 8174.55ng/L and 2594.45hng/mL respectively. Coadministration of Honghua and clopidogrel resulted in a 63.5% and 79.7% increase in the AUC respectively. The Cmax of FA was significantly increased by coadministration with clopidogrel (74.3%, p<0.01). Moreover, the Tmax of FA when coadministered with Honghua or clopidogrel was 3 and 3.76 times slower than when administered alone. Other pharmacokinetic parameters estimated for FA were also altered by the coadministrations, but no statistically significant differences were observed.
FA was rapidly absorbed with a low bioavailability after a single oral administration. The pharmacokinetics profile of FA in rats was partly altered by the coadministration of FA with Honghua or clopidogrel.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21704146</pmid><doi>10.1016/j.jep.2011.06.011</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Oral Animals Biological and medical sciences Biological Availability Cardiovascular Agents - administration & dosage Cardiovascular Agents - blood Cardiovascular Agents - pharmacokinetics Carthamus tinctorius Clopidogrel Coumaric Acids - administration & dosage Coumaric Acids - blood Coumaric Acids - pharmacokinetics Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - pharmacokinetics Ferulic acid General pharmacology Herb-Drug Interactions Honghua Intestinal Absorption - drug effects Liquid chromatography Male Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacokinetics Pharmacology. Drug treatments Platelet Aggregation Inhibitors - administration & dosage Rats Rats, Sprague-Dawley Ticlopidine - administration & dosage Ticlopidine - analogs & derivatives |
| title | Pharmacokinetics of ferulic acid and potential interactions with Honghua and clopidogrel in rats |
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