Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation
Objective To describe the first live birth after transplantation of ovarian tissue following overnight transportation of the tissue before freezing. Design Technical note. Setting University department of obstetrics and gynecology. Patient(s) A 25-year-old cancer survivor with previous Hodgkin disea...
Gespeichert in:
| Veröffentlicht in: | Fertility and sterility 2012-02, Vol.97 (2), p.387-390 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 390 |
|---|---|
| container_issue | 2 |
| container_start_page | 387 |
| container_title | Fertility and sterility |
| container_volume | 97 |
| creator | Dittrich, Ralf, Ph.D Lotz, Laura Keck, Gudrun, Ph.D Hoffmann, Inge Mueller, Andreas, M.D Beckmann, Matthias W., M.D van der Ven, Hans, M.D Montag, Markus, Ph.D |
| description | Objective To describe the first live birth after transplantation of ovarian tissue following overnight transportation of the tissue before freezing. Design Technical note. Setting University department of obstetrics and gynecology. Patient(s) A 25-year-old cancer survivor with previous Hodgkin disease and relapse. Intervention(s) The ovarian tissue was kept cool for >20 hours in a special transport medium and a special cooling device before it was cryopreserved. After premature ovarian failure due to preconditioning chemotherapy for bone marrow transplantation, the cryopreserved ovarian tissue was transplanted orthotopically. Main Outcome Measure(s) Resumption of ovarian function after transplantation, recovery of fertility, and pregnancy. Result(s) Ovarian function returned in the patient 3 months after transplantation, as shown by follicle development and estrogen production. During the fifth menstrual cycle, mild stimulation with FSH was initiated in accordance with a low-dose protocol. When ultrasonography revealed a follicle 18–20 mm in size in the ovarian graft, hCG was added and the patient had sexual intercourse at the optimal time point. On day 14 of the luteal phase, hCG concentration and vaginal echography confirmed a viable intrauterine pregnancy, which resulted in a healthy live birth. Conclusion(s) Overnight transportation of ovarian tissue appears to be possible in combination with appropriate transportation logistics. However, further investigations are needed before this procedure can be offered as a chance for women to preserve fertility independently of direct access to a tissue-processing bank. |
| doi_str_mv | 10.1016/j.fertnstert.2011.11.047 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_919226781</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0015028211028238</els_id><sourcerecordid>919226781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c598t-5c1cc90c3e95f5fe40885398858feae102c5afab51e525d0ebdea2543d96bc283</originalsourceid><addsrcrecordid>eNqNkk1vEzEQhi0EomnhL8BeEKcNtjfejwsSraAgReJQera83nHqsLHD2BuUf88sCVTihGSNJeuZd8bvDGOF4EvBRf1uu3SAOaRMcSm5EEs6fNU8YQuhVF2qWlVP2YJzoUouW3nBLlPacs5r0cjn7EJK0TSVEAsW1v4ARe8xPxTGkV4RDwa9CUX2KU1QmCnHjCak_WhCNtnHULg4jvGnDxuCAYPfPOTixEQ8Iz24iFBYPMY9QgI8_H5_wZ45MyZ4eb6v2P2nj99uPpfrr7dfbj6sS6u6NpfKCms7bivolFMOVrxtVdVRaB0YEFxaZZzplQAl1cChH8BItaqGru6tbKsr9vaku8f4Y4KU9c4nCyP9AeKUdCc6KeumFUS2J9JiTAnB6T36ncGjFlzPZuutfjRbz2ZrOmQ2pb46F5n6HQx_E_-4S8CbM2CSNaMji6xPj5yqieI1ca9PnDNRmw0Sc39HlRQNkKbXzUrXJwLItIMH1Ml6CBYGj2CzHqL_n37f_yNiRx88dfYdjpC2ccJAQ9FCJ6m5vpvXZ94e6pFi1Va_AC9nxRk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>919226781</pqid></control><display><type>article</type><title>Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Dittrich, Ralf, Ph.D ; Lotz, Laura ; Keck, Gudrun, Ph.D ; Hoffmann, Inge ; Mueller, Andreas, M.D ; Beckmann, Matthias W., M.D ; van der Ven, Hans, M.D ; Montag, Markus, Ph.D</creator><creatorcontrib>Dittrich, Ralf, Ph.D ; Lotz, Laura ; Keck, Gudrun, Ph.D ; Hoffmann, Inge ; Mueller, Andreas, M.D ; Beckmann, Matthias W., M.D ; van der Ven, Hans, M.D ; Montag, Markus, Ph.D</creatorcontrib><description>Objective To describe the first live birth after transplantation of ovarian tissue following overnight transportation of the tissue before freezing. Design Technical note. Setting University department of obstetrics and gynecology. Patient(s) A 25-year-old cancer survivor with previous Hodgkin disease and relapse. Intervention(s) The ovarian tissue was kept cool for >20 hours in a special transport medium and a special cooling device before it was cryopreserved. After premature ovarian failure due to preconditioning chemotherapy for bone marrow transplantation, the cryopreserved ovarian tissue was transplanted orthotopically. Main Outcome Measure(s) Resumption of ovarian function after transplantation, recovery of fertility, and pregnancy. Result(s) Ovarian function returned in the patient 3 months after transplantation, as shown by follicle development and estrogen production. During the fifth menstrual cycle, mild stimulation with FSH was initiated in accordance with a low-dose protocol. When ultrasonography revealed a follicle 18–20 mm in size in the ovarian graft, hCG was added and the patient had sexual intercourse at the optimal time point. On day 14 of the luteal phase, hCG concentration and vaginal echography confirmed a viable intrauterine pregnancy, which resulted in a healthy live birth. Conclusion(s) Overnight transportation of ovarian tissue appears to be possible in combination with appropriate transportation logistics. However, further investigations are needed before this procedure can be offered as a chance for women to preserve fertility independently of direct access to a tissue-processing bank.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2011.11.047</identifier><identifier>PMID: 22177311</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; animal ovaries ; Antineoplastic Agents - adverse effects ; autografting ; Biological and medical sciences ; bone marrow transplant ; Bone Marrow Transplantation ; chemotherapy ; cooling ; Cryopreservation ; Equipment Design ; Female ; Fertility Agents, Female - administration & dosage ; Fertility preservation ; Fertility Preservation - methods ; follicle-stimulating hormone ; freezing ; Gynecology. Andrology. Obstetrics ; Hodgkin disease ; Hodgkin Disease - drug therapy ; Hodgkin Disease - surgery ; Hodgkin Disease - therapy ; human chorionic gonadotropin ; Humans ; Internal Medicine ; Live Birth ; Medical sciences ; menstrual cycle ; Obstetrics and Gynecology ; Organ Preservation ; Organ Preservation Solutions - therapeutic use ; orthotopic ; ovarian tissue cryopreservation ; ovarian tissue transplantation ; Ovary - transplantation ; patients ; Pregnancy ; Primary Ovarian Insufficiency - chemically induced ; Primary Ovarian Insufficiency - surgery ; Recurrence ; relapse ; Time Factors ; Transplantation Conditioning - adverse effects ; Transplantation, Autologous ; transportation ; Transportation - instrumentation ; Treatment Outcome ; ultrasonography ; women</subject><ispartof>Fertility and sterility, 2012-02, Vol.97 (2), p.387-390</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2012 American Society for Reproductive Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c598t-5c1cc90c3e95f5fe40885398858feae102c5afab51e525d0ebdea2543d96bc283</citedby><cites>FETCH-LOGICAL-c598t-5c1cc90c3e95f5fe40885398858feae102c5afab51e525d0ebdea2543d96bc283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028211028238$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25631106$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22177311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dittrich, Ralf, Ph.D</creatorcontrib><creatorcontrib>Lotz, Laura</creatorcontrib><creatorcontrib>Keck, Gudrun, Ph.D</creatorcontrib><creatorcontrib>Hoffmann, Inge</creatorcontrib><creatorcontrib>Mueller, Andreas, M.D</creatorcontrib><creatorcontrib>Beckmann, Matthias W., M.D</creatorcontrib><creatorcontrib>van der Ven, Hans, M.D</creatorcontrib><creatorcontrib>Montag, Markus, Ph.D</creatorcontrib><title>Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To describe the first live birth after transplantation of ovarian tissue following overnight transportation of the tissue before freezing. Design Technical note. Setting University department of obstetrics and gynecology. Patient(s) A 25-year-old cancer survivor with previous Hodgkin disease and relapse. Intervention(s) The ovarian tissue was kept cool for >20 hours in a special transport medium and a special cooling device before it was cryopreserved. After premature ovarian failure due to preconditioning chemotherapy for bone marrow transplantation, the cryopreserved ovarian tissue was transplanted orthotopically. Main Outcome Measure(s) Resumption of ovarian function after transplantation, recovery of fertility, and pregnancy. Result(s) Ovarian function returned in the patient 3 months after transplantation, as shown by follicle development and estrogen production. During the fifth menstrual cycle, mild stimulation with FSH was initiated in accordance with a low-dose protocol. When ultrasonography revealed a follicle 18–20 mm in size in the ovarian graft, hCG was added and the patient had sexual intercourse at the optimal time point. On day 14 of the luteal phase, hCG concentration and vaginal echography confirmed a viable intrauterine pregnancy, which resulted in a healthy live birth. Conclusion(s) Overnight transportation of ovarian tissue appears to be possible in combination with appropriate transportation logistics. However, further investigations are needed before this procedure can be offered as a chance for women to preserve fertility independently of direct access to a tissue-processing bank.</description><subject>Adult</subject><subject>animal ovaries</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>autografting</subject><subject>Biological and medical sciences</subject><subject>bone marrow transplant</subject><subject>Bone Marrow Transplantation</subject><subject>chemotherapy</subject><subject>cooling</subject><subject>Cryopreservation</subject><subject>Equipment Design</subject><subject>Female</subject><subject>Fertility Agents, Female - administration & dosage</subject><subject>Fertility preservation</subject><subject>Fertility Preservation - methods</subject><subject>follicle-stimulating hormone</subject><subject>freezing</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hodgkin disease</subject><subject>Hodgkin Disease - drug therapy</subject><subject>Hodgkin Disease - surgery</subject><subject>Hodgkin Disease - therapy</subject><subject>human chorionic gonadotropin</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Live Birth</subject><subject>Medical sciences</subject><subject>menstrual cycle</subject><subject>Obstetrics and Gynecology</subject><subject>Organ Preservation</subject><subject>Organ Preservation Solutions - therapeutic use</subject><subject>orthotopic</subject><subject>ovarian tissue cryopreservation</subject><subject>ovarian tissue transplantation</subject><subject>Ovary - transplantation</subject><subject>patients</subject><subject>Pregnancy</subject><subject>Primary Ovarian Insufficiency - chemically induced</subject><subject>Primary Ovarian Insufficiency - surgery</subject><subject>Recurrence</subject><subject>relapse</subject><subject>Time Factors</subject><subject>Transplantation Conditioning - adverse effects</subject><subject>Transplantation, Autologous</subject><subject>transportation</subject><subject>Transportation - instrumentation</subject><subject>Treatment Outcome</subject><subject>ultrasonography</subject><subject>women</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1vEzEQhi0EomnhL8BeEKcNtjfejwsSraAgReJQera83nHqsLHD2BuUf88sCVTihGSNJeuZd8bvDGOF4EvBRf1uu3SAOaRMcSm5EEs6fNU8YQuhVF2qWlVP2YJzoUouW3nBLlPacs5r0cjn7EJK0TSVEAsW1v4ARe8xPxTGkV4RDwa9CUX2KU1QmCnHjCak_WhCNtnHULg4jvGnDxuCAYPfPOTixEQ8Iz24iFBYPMY9QgI8_H5_wZ45MyZ4eb6v2P2nj99uPpfrr7dfbj6sS6u6NpfKCms7bivolFMOVrxtVdVRaB0YEFxaZZzplQAl1cChH8BItaqGru6tbKsr9vaku8f4Y4KU9c4nCyP9AeKUdCc6KeumFUS2J9JiTAnB6T36ncGjFlzPZuutfjRbz2ZrOmQ2pb46F5n6HQx_E_-4S8CbM2CSNaMji6xPj5yqieI1ca9PnDNRmw0Sc39HlRQNkKbXzUrXJwLItIMH1Ml6CBYGj2CzHqL_n37f_yNiRx88dfYdjpC2ccJAQ9FCJ6m5vpvXZ94e6pFi1Va_AC9nxRk</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Dittrich, Ralf, Ph.D</creator><creator>Lotz, Laura</creator><creator>Keck, Gudrun, Ph.D</creator><creator>Hoffmann, Inge</creator><creator>Mueller, Andreas, M.D</creator><creator>Beckmann, Matthias W., M.D</creator><creator>van der Ven, Hans, M.D</creator><creator>Montag, Markus, Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation</title><author>Dittrich, Ralf, Ph.D ; Lotz, Laura ; Keck, Gudrun, Ph.D ; Hoffmann, Inge ; Mueller, Andreas, M.D ; Beckmann, Matthias W., M.D ; van der Ven, Hans, M.D ; Montag, Markus, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c598t-5c1cc90c3e95f5fe40885398858feae102c5afab51e525d0ebdea2543d96bc283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>animal ovaries</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>autografting</topic><topic>Biological and medical sciences</topic><topic>bone marrow transplant</topic><topic>Bone Marrow Transplantation</topic><topic>chemotherapy</topic><topic>cooling</topic><topic>Cryopreservation</topic><topic>Equipment Design</topic><topic>Female</topic><topic>Fertility Agents, Female - administration & dosage</topic><topic>Fertility preservation</topic><topic>Fertility Preservation - methods</topic><topic>follicle-stimulating hormone</topic><topic>freezing</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hodgkin disease</topic><topic>Hodgkin Disease - drug therapy</topic><topic>Hodgkin Disease - surgery</topic><topic>Hodgkin Disease - therapy</topic><topic>human chorionic gonadotropin</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Live Birth</topic><topic>Medical sciences</topic><topic>menstrual cycle</topic><topic>Obstetrics and Gynecology</topic><topic>Organ Preservation</topic><topic>Organ Preservation Solutions - therapeutic use</topic><topic>orthotopic</topic><topic>ovarian tissue cryopreservation</topic><topic>ovarian tissue transplantation</topic><topic>Ovary - transplantation</topic><topic>patients</topic><topic>Pregnancy</topic><topic>Primary Ovarian Insufficiency - chemically induced</topic><topic>Primary Ovarian Insufficiency - surgery</topic><topic>Recurrence</topic><topic>relapse</topic><topic>Time Factors</topic><topic>Transplantation Conditioning - adverse effects</topic><topic>Transplantation, Autologous</topic><topic>transportation</topic><topic>Transportation - instrumentation</topic><topic>Treatment Outcome</topic><topic>ultrasonography</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dittrich, Ralf, Ph.D</creatorcontrib><creatorcontrib>Lotz, Laura</creatorcontrib><creatorcontrib>Keck, Gudrun, Ph.D</creatorcontrib><creatorcontrib>Hoffmann, Inge</creatorcontrib><creatorcontrib>Mueller, Andreas, M.D</creatorcontrib><creatorcontrib>Beckmann, Matthias W., M.D</creatorcontrib><creatorcontrib>van der Ven, Hans, M.D</creatorcontrib><creatorcontrib>Montag, Markus, Ph.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dittrich, Ralf, Ph.D</au><au>Lotz, Laura</au><au>Keck, Gudrun, Ph.D</au><au>Hoffmann, Inge</au><au>Mueller, Andreas, M.D</au><au>Beckmann, Matthias W., M.D</au><au>van der Ven, Hans, M.D</au><au>Montag, Markus, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>97</volume><issue>2</issue><spage>387</spage><epage>390</epage><pages>387-390</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To describe the first live birth after transplantation of ovarian tissue following overnight transportation of the tissue before freezing. Design Technical note. Setting University department of obstetrics and gynecology. Patient(s) A 25-year-old cancer survivor with previous Hodgkin disease and relapse. Intervention(s) The ovarian tissue was kept cool for >20 hours in a special transport medium and a special cooling device before it was cryopreserved. After premature ovarian failure due to preconditioning chemotherapy for bone marrow transplantation, the cryopreserved ovarian tissue was transplanted orthotopically. Main Outcome Measure(s) Resumption of ovarian function after transplantation, recovery of fertility, and pregnancy. Result(s) Ovarian function returned in the patient 3 months after transplantation, as shown by follicle development and estrogen production. During the fifth menstrual cycle, mild stimulation with FSH was initiated in accordance with a low-dose protocol. When ultrasonography revealed a follicle 18–20 mm in size in the ovarian graft, hCG was added and the patient had sexual intercourse at the optimal time point. On day 14 of the luteal phase, hCG concentration and vaginal echography confirmed a viable intrauterine pregnancy, which resulted in a healthy live birth. Conclusion(s) Overnight transportation of ovarian tissue appears to be possible in combination with appropriate transportation logistics. However, further investigations are needed before this procedure can be offered as a chance for women to preserve fertility independently of direct access to a tissue-processing bank.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22177311</pmid><doi>10.1016/j.fertnstert.2011.11.047</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0015-0282 |
| ispartof | Fertility and sterility, 2012-02, Vol.97 (2), p.387-390 |
| issn | 0015-0282 1556-5653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_919226781 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult animal ovaries Antineoplastic Agents - adverse effects autografting Biological and medical sciences bone marrow transplant Bone Marrow Transplantation chemotherapy cooling Cryopreservation Equipment Design Female Fertility Agents, Female - administration & dosage Fertility preservation Fertility Preservation - methods follicle-stimulating hormone freezing Gynecology. Andrology. Obstetrics Hodgkin disease Hodgkin Disease - drug therapy Hodgkin Disease - surgery Hodgkin Disease - therapy human chorionic gonadotropin Humans Internal Medicine Live Birth Medical sciences menstrual cycle Obstetrics and Gynecology Organ Preservation Organ Preservation Solutions - therapeutic use orthotopic ovarian tissue cryopreservation ovarian tissue transplantation Ovary - transplantation patients Pregnancy Primary Ovarian Insufficiency - chemically induced Primary Ovarian Insufficiency - surgery Recurrence relapse Time Factors Transplantation Conditioning - adverse effects Transplantation, Autologous transportation Transportation - instrumentation Treatment Outcome ultrasonography women |
| title | Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T13%3A32%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Live%20birth%20after%20ovarian%20tissue%20autotransplantation%20following%20overnight%20transportation%20before%20cryopreservation&rft.jtitle=Fertility%20and%20sterility&rft.au=Dittrich,%20Ralf,%20Ph.D&rft.date=2012-02-01&rft.volume=97&rft.issue=2&rft.spage=387&rft.epage=390&rft.pages=387-390&rft.issn=0015-0282&rft.eissn=1556-5653&rft.coden=FESTAS&rft_id=info:doi/10.1016/j.fertnstert.2011.11.047&rft_dat=%3Cproquest_cross%3E919226781%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=919226781&rft_id=info:pmid/22177311&rft_els_id=S0015028211028238&rfr_iscdi=true |