Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice

Aims/hypothesis The fat-derived hormone leptin plays a crucial role in the maintenance of normal body weight and energy expenditure as well as in glucose homeostasis. Recently, it was reported that the liver-derived protein, insulin-like growth factor binding protein-2 (IGFBP-2), is responsible for...

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Veröffentlicht in:	Diabetologia 2012-03, Vol.55 (3), p.752-762
Hauptverfasser:	Levi, J., Huynh, F. K., Denroche, H. C., Neumann, U. H., Glavas, M. M., Covey, S. D., Kieffer, T. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Biological and medical sciences Blood Glucose - analysis Crosses, Genetic Cytomegalovirus Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glucose Homeostasis Human Physiology Hypotheses Insulin - blood Insulin resistance Insulin-Like Growth Factor Binding Protein 2 - blood Insulin-Like Growth Factor Binding Protein 2 - metabolism Insulin-like growth factors Internal Medicine Leptin - administration & dosage Leptin - genetics Leptin - metabolism Life sciences Liver Liver - innervation Liver - metabolism Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains Mice, Transgenic Obesity - blood Obesity - metabolism Obesity - physiopathology Physiology Plasma Protein Isoforms - genetics Protein Isoforms - metabolism Proteins Receptors, Leptin - genetics Receptors, Leptin - metabolism Signal Transduction Up-Regulation Vagotomy, Truncal Vagus Nerve - physiopathology Vagus Nerve - surgery Weight control
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