Dormancy in mammalian malaria
This analysis principally concerns biological aspects of dormancy in mammalian malaria, with particular reference to the hypnozoite. Research is needed to reveal what happens to sporozoites of Plasmodium cynomolgi between the time of inoculation and when hypnozoites are first seen in the liver 36–40...
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| Veröffentlicht in: | Trends in parasitology 2012-02, Vol.28 (2), p.39-45 |
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| creator | Markus, Miles B |
| description | This analysis principally concerns biological aspects of dormancy in mammalian malaria, with particular reference to the hypnozoite. Research is needed to reveal what happens to sporozoites of Plasmodium cynomolgi between the time of inoculation and when hypnozoites are first seen in the liver 36–40 h later. It is likely that hypnozoites of relapsing malarial parasites will prove to be directly sporozoite-derived rather than merozoite-derived. There is indirect evidence that, contrary to what is generally assumed, activation of hypnozoites might not be the only cause of recurrent Plasmodium vivax malaria. Latent stages pose a threat to success in eradicating malaria; some suggestions are therefore made for demystifying work on hypnozoites and quiescent merozoites. |
| doi_str_mv | 10.1016/j.pt.2011.10.005 |
| format | Article |
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| subjects | Animals Antimalarials - pharmacology Antimalarials - therapeutic use Biological and medical sciences Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology General aspects Hepatocytes - parasitology Human protozoal diseases Infectious Disease Infectious diseases Life Cycle Stages Malaria Malaria - drug therapy Malaria - parasitology Mammalia Medical sciences Parasitic diseases Plasmodium - drug effects Plasmodium - growth & development Plasmodium - physiology Plasmodium - ultrastructure Protozoal diseases Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution |
| title | Dormancy in mammalian malaria |
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