Clinical and molecular characterization of ESBL-producing enterobacteria isolated from bacteremia in a university hospital
Extended-spectrum-β-lactamases (ESBL) are plasmid-encoded enzymes that confer resistance to multiple antimicrobials. ESBL-producing enterobacteria that cause bacteremia limit therapeutic options and increase mortality. To perform a clinical and molecular description of bacteremia caused by ESBL-prod...
Gespeichert in:
Veröffentlicht in: | Revista chilena de infectología 2011-12, Vol.28 (6), p.563-571 |
---|---|
Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | spa |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 571 |
---|---|
container_issue | 6 |
container_start_page | 563 |
container_title | Revista chilena de infectología |
container_volume | 28 |
creator | García C, Patricia Rubilar P, Carla Vicentini H, Daniel Román G, Juan C León C, Eugenia Muñoz C, Gabriel Domínguez Y, Mariana González R, Gerardo Bello T, Helia Labarca L, Jaime |
description | Extended-spectrum-β-lactamases (ESBL) are plasmid-encoded enzymes that confer resistance to multiple antimicrobials. ESBL-producing enterobacteria that cause bacteremia limit therapeutic options and increase mortality.
To perform a clinical and molecular description of bacteremia caused by ESBL-producing enterobacteria.
We retrospectively studied the cases of bacteremia due to ESBL-producing Escherichia coli, Klebsiella pneumoniae and Proteus spp in adults admitted to a university hospital during the years 2004-2007. We reviewed the clinical records and antimicrobial susceptibility patterns. Molecular typing was performed by polymerase chain reaction and study of clonality by pulsed-field electrophoresis.
We found a prevalence of 9.8% ESBL in enterobacteria causing bacteremia. Decreased susceptibility to quinolones and aminoglycosides was observed, without resistance to carbapenems. The predominant ESBL types were CTX-M (96%), TEM (62%) and GES (28%). 79% of the strains presented more than one type of ESBL. Clinical analysis revealed high prevalence of risk factors, previous use of antimicrobials and of invasive devices. There was no significant clonality.
The presence of ESBLs in bloodstream infections is a clinical problem that must be considered when choosing empiric therapy. |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_918934271</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>918934271</sourcerecordid><originalsourceid>FETCH-LOGICAL-p550-22184e9469c3cea54878c9680df7ae90f85cc8af457619b0fe14f64640ebb0ec3</originalsourceid><addsrcrecordid>eNo1kM1OwzAQhH0A0VJ4BeQbp0i24zjOEaryI1XiQO_RxllTI8cudoLUPj1BhdNKM592Z_aCLFnNVcEZ1wtynfMnY6JWnF-RhRBCK6XZkpzW3gVnwFMIPR2iRzN5SNTsIYEZMbkTjC4GGi3dvD9ui0OK_WRc-KAYZjt2Zwqoy9HDiD21KQ70LOPwawQKdAruG1N245HuYz64EfwNubTgM97-zRXZPW1265di-_b8un6YT1UVK4TgWmIjVWNKg1BJXWvTzNl7WwM2zOrKGA1WVnO3pmMWubRKKsmw6xiackXuz2vn5F8T5rEdXDboPQSMU24brptSiprP5N0fOXUD9u0huQHSsf3_VvkDh25nvA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>918934271</pqid></control><display><type>article</type><title>Clinical and molecular characterization of ESBL-producing enterobacteria isolated from bacteremia in a university hospital</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>García C, Patricia ; Rubilar P, Carla ; Vicentini H, Daniel ; Román G, Juan C ; León C, Eugenia ; Muñoz C, Gabriel ; Domínguez Y, Mariana ; González R, Gerardo ; Bello T, Helia ; Labarca L, Jaime</creator><creatorcontrib>García C, Patricia ; Rubilar P, Carla ; Vicentini H, Daniel ; Román G, Juan C ; León C, Eugenia ; Muñoz C, Gabriel ; Domínguez Y, Mariana ; González R, Gerardo ; Bello T, Helia ; Labarca L, Jaime</creatorcontrib><description>Extended-spectrum-β-lactamases (ESBL) are plasmid-encoded enzymes that confer resistance to multiple antimicrobials. ESBL-producing enterobacteria that cause bacteremia limit therapeutic options and increase mortality.
To perform a clinical and molecular description of bacteremia caused by ESBL-producing enterobacteria.
We retrospectively studied the cases of bacteremia due to ESBL-producing Escherichia coli, Klebsiella pneumoniae and Proteus spp in adults admitted to a university hospital during the years 2004-2007. We reviewed the clinical records and antimicrobial susceptibility patterns. Molecular typing was performed by polymerase chain reaction and study of clonality by pulsed-field electrophoresis.
We found a prevalence of 9.8% ESBL in enterobacteria causing bacteremia. Decreased susceptibility to quinolones and aminoglycosides was observed, without resistance to carbapenems. The predominant ESBL types were CTX-M (96%), TEM (62%) and GES (28%). 79% of the strains presented more than one type of ESBL. Clinical analysis revealed high prevalence of risk factors, previous use of antimicrobials and of invasive devices. There was no significant clonality.
The presence of ESBLs in bloodstream infections is a clinical problem that must be considered when choosing empiric therapy.</description><identifier>ISSN: 0716-1018</identifier><identifier>PMID: 22286680</identifier><language>spa</language><publisher>Chile</publisher><subject>Adult ; Aged ; Anti-Bacterial Agents - pharmacology ; Bacteremia - microbiology ; beta-Lactamases - genetics ; beta-Lactamases - metabolism ; Electrophoresis, Gel, Pulsed-Field ; Escherichia coli - drug effects ; Escherichia coli - enzymology ; Escherichia coli - genetics ; Escherichia coli Infections - microbiology ; Hospitals, University ; Humans ; Klebsiella Infections - microbiology ; Klebsiella pneumoniae - drug effects ; Klebsiella pneumoniae - enzymology ; Klebsiella pneumoniae - genetics ; Microbial Sensitivity Tests ; Polymerase Chain Reaction ; Prevalence ; Proteus - drug effects ; Proteus - enzymology ; Proteus - genetics ; Proteus Infections - microbiology ; Retrospective Studies</subject><ispartof>Revista chilena de infectología, 2011-12, Vol.28 (6), p.563-571</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22286680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García C, Patricia</creatorcontrib><creatorcontrib>Rubilar P, Carla</creatorcontrib><creatorcontrib>Vicentini H, Daniel</creatorcontrib><creatorcontrib>Román G, Juan C</creatorcontrib><creatorcontrib>León C, Eugenia</creatorcontrib><creatorcontrib>Muñoz C, Gabriel</creatorcontrib><creatorcontrib>Domínguez Y, Mariana</creatorcontrib><creatorcontrib>González R, Gerardo</creatorcontrib><creatorcontrib>Bello T, Helia</creatorcontrib><creatorcontrib>Labarca L, Jaime</creatorcontrib><title>Clinical and molecular characterization of ESBL-producing enterobacteria isolated from bacteremia in a university hospital</title><title>Revista chilena de infectología</title><addtitle>Rev Chilena Infectol</addtitle><description>Extended-spectrum-β-lactamases (ESBL) are plasmid-encoded enzymes that confer resistance to multiple antimicrobials. ESBL-producing enterobacteria that cause bacteremia limit therapeutic options and increase mortality.
To perform a clinical and molecular description of bacteremia caused by ESBL-producing enterobacteria.
We retrospectively studied the cases of bacteremia due to ESBL-producing Escherichia coli, Klebsiella pneumoniae and Proteus spp in adults admitted to a university hospital during the years 2004-2007. We reviewed the clinical records and antimicrobial susceptibility patterns. Molecular typing was performed by polymerase chain reaction and study of clonality by pulsed-field electrophoresis.
We found a prevalence of 9.8% ESBL in enterobacteria causing bacteremia. Decreased susceptibility to quinolones and aminoglycosides was observed, without resistance to carbapenems. The predominant ESBL types were CTX-M (96%), TEM (62%) and GES (28%). 79% of the strains presented more than one type of ESBL. Clinical analysis revealed high prevalence of risk factors, previous use of antimicrobials and of invasive devices. There was no significant clonality.
The presence of ESBLs in bloodstream infections is a clinical problem that must be considered when choosing empiric therapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteremia - microbiology</subject><subject>beta-Lactamases - genetics</subject><subject>beta-Lactamases - metabolism</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - enzymology</subject><subject>Escherichia coli - genetics</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Klebsiella Infections - microbiology</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Klebsiella pneumoniae - enzymology</subject><subject>Klebsiella pneumoniae - genetics</subject><subject>Microbial Sensitivity Tests</subject><subject>Polymerase Chain Reaction</subject><subject>Prevalence</subject><subject>Proteus - drug effects</subject><subject>Proteus - enzymology</subject><subject>Proteus - genetics</subject><subject>Proteus Infections - microbiology</subject><subject>Retrospective Studies</subject><issn>0716-1018</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1OwzAQhH0A0VJ4BeQbp0i24zjOEaryI1XiQO_RxllTI8cudoLUPj1BhdNKM592Z_aCLFnNVcEZ1wtynfMnY6JWnF-RhRBCK6XZkpzW3gVnwFMIPR2iRzN5SNTsIYEZMbkTjC4GGi3dvD9ui0OK_WRc-KAYZjt2Zwqoy9HDiD21KQ70LOPwawQKdAruG1N245HuYz64EfwNubTgM97-zRXZPW1265di-_b8un6YT1UVK4TgWmIjVWNKg1BJXWvTzNl7WwM2zOrKGA1WVnO3pmMWubRKKsmw6xiackXuz2vn5F8T5rEdXDboPQSMU24brptSiprP5N0fOXUD9u0huQHSsf3_VvkDh25nvA</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>García C, Patricia</creator><creator>Rubilar P, Carla</creator><creator>Vicentini H, Daniel</creator><creator>Román G, Juan C</creator><creator>León C, Eugenia</creator><creator>Muñoz C, Gabriel</creator><creator>Domínguez Y, Mariana</creator><creator>González R, Gerardo</creator><creator>Bello T, Helia</creator><creator>Labarca L, Jaime</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>Clinical and molecular characterization of ESBL-producing enterobacteria isolated from bacteremia in a university hospital</title><author>García C, Patricia ; Rubilar P, Carla ; Vicentini H, Daniel ; Román G, Juan C ; León C, Eugenia ; Muñoz C, Gabriel ; Domínguez Y, Mariana ; González R, Gerardo ; Bello T, Helia ; Labarca L, Jaime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p550-22184e9469c3cea54878c9680df7ae90f85cc8af457619b0fe14f64640ebb0ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacteremia - microbiology</topic><topic>beta-Lactamases - genetics</topic><topic>beta-Lactamases - metabolism</topic><topic>Electrophoresis, Gel, Pulsed-Field</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - enzymology</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli Infections - microbiology</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Klebsiella Infections - microbiology</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>Klebsiella pneumoniae - enzymology</topic><topic>Klebsiella pneumoniae - genetics</topic><topic>Microbial Sensitivity Tests</topic><topic>Polymerase Chain Reaction</topic><topic>Prevalence</topic><topic>Proteus - drug effects</topic><topic>Proteus - enzymology</topic><topic>Proteus - genetics</topic><topic>Proteus Infections - microbiology</topic><topic>Retrospective Studies</topic><toplevel>online_resources</toplevel><creatorcontrib>García C, Patricia</creatorcontrib><creatorcontrib>Rubilar P, Carla</creatorcontrib><creatorcontrib>Vicentini H, Daniel</creatorcontrib><creatorcontrib>Román G, Juan C</creatorcontrib><creatorcontrib>León C, Eugenia</creatorcontrib><creatorcontrib>Muñoz C, Gabriel</creatorcontrib><creatorcontrib>Domínguez Y, Mariana</creatorcontrib><creatorcontrib>González R, Gerardo</creatorcontrib><creatorcontrib>Bello T, Helia</creatorcontrib><creatorcontrib>Labarca L, Jaime</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista chilena de infectología</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García C, Patricia</au><au>Rubilar P, Carla</au><au>Vicentini H, Daniel</au><au>Román G, Juan C</au><au>León C, Eugenia</au><au>Muñoz C, Gabriel</au><au>Domínguez Y, Mariana</au><au>González R, Gerardo</au><au>Bello T, Helia</au><au>Labarca L, Jaime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and molecular characterization of ESBL-producing enterobacteria isolated from bacteremia in a university hospital</atitle><jtitle>Revista chilena de infectología</jtitle><addtitle>Rev Chilena Infectol</addtitle><date>2011-12</date><risdate>2011</risdate><volume>28</volume><issue>6</issue><spage>563</spage><epage>571</epage><pages>563-571</pages><issn>0716-1018</issn><abstract>Extended-spectrum-β-lactamases (ESBL) are plasmid-encoded enzymes that confer resistance to multiple antimicrobials. ESBL-producing enterobacteria that cause bacteremia limit therapeutic options and increase mortality.
To perform a clinical and molecular description of bacteremia caused by ESBL-producing enterobacteria.
We retrospectively studied the cases of bacteremia due to ESBL-producing Escherichia coli, Klebsiella pneumoniae and Proteus spp in adults admitted to a university hospital during the years 2004-2007. We reviewed the clinical records and antimicrobial susceptibility patterns. Molecular typing was performed by polymerase chain reaction and study of clonality by pulsed-field electrophoresis.
We found a prevalence of 9.8% ESBL in enterobacteria causing bacteremia. Decreased susceptibility to quinolones and aminoglycosides was observed, without resistance to carbapenems. The predominant ESBL types were CTX-M (96%), TEM (62%) and GES (28%). 79% of the strains presented more than one type of ESBL. Clinical analysis revealed high prevalence of risk factors, previous use of antimicrobials and of invasive devices. There was no significant clonality.
The presence of ESBLs in bloodstream infections is a clinical problem that must be considered when choosing empiric therapy.</abstract><cop>Chile</cop><pmid>22286680</pmid><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0716-1018 |
ispartof | Revista chilena de infectología, 2011-12, Vol.28 (6), p.563-571 |
issn | 0716-1018 |
language | spa |
recordid | cdi_proquest_miscellaneous_918934271 |
source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
subjects | Adult Aged Anti-Bacterial Agents - pharmacology Bacteremia - microbiology beta-Lactamases - genetics beta-Lactamases - metabolism Electrophoresis, Gel, Pulsed-Field Escherichia coli - drug effects Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli Infections - microbiology Hospitals, University Humans Klebsiella Infections - microbiology Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Microbial Sensitivity Tests Polymerase Chain Reaction Prevalence Proteus - drug effects Proteus - enzymology Proteus - genetics Proteus Infections - microbiology Retrospective Studies |
title | Clinical and molecular characterization of ESBL-producing enterobacteria isolated from bacteremia in a university hospital |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T20%3A00%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20and%20molecular%20characterization%20of%20ESBL-producing%20enterobacteria%20isolated%20from%20bacteremia%20in%20a%20university%20hospital&rft.jtitle=Revista%20chilena%20de%20infectolog%C3%ADa&rft.au=Garc%C3%ADa%20C,%20Patricia&rft.date=2011-12&rft.volume=28&rft.issue=6&rft.spage=563&rft.epage=571&rft.pages=563-571&rft.issn=0716-1018&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E918934271%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=918934271&rft_id=info:pmid/22286680&rfr_iscdi=true |