N-acetyltransferase 2 polymorphisms and risk of anti-tuberculosis drug-induced hepatotoxicity in Caucasians

OBJECTIVE: To analyse slow-acetylation N-acetyltransferase 2 (NAT2) polymorphisms for their association with the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH). DESIGN: A case-control study including Caucasian patients with tuberculosis (TB) treated with isoniazid, r ifampicin and pyra...

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Veröffentlicht in:	The international journal of tuberculosis and lung disease 2011-10, Vol.15 (10), p.1403-1408
Hauptverfasser:	Leiro-Fernandez, V., Valverde, D., Vázquez-Gallardo, R., Botana-Rial, M., Constenla, L., Agúndez, J.A., Fernández-Villar, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetilator Status Adult Antitubercular Agents - adverse effects Antitubercular Agents - metabolism Arylamine N-Acetyltransferase - genetics Arylamine N-Acetyltransferase - metabolism Bacterial diseases Biological and medical sciences Case-Control Studies Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - ethnology Chemical and Drug Induced Liver Injury - genetics Chi-Square Distribution European Continental Ancestry Group - genetics Female Gene Frequency Genetic Predisposition to Disease Haplotypes Hepatotoxicity Human bacterial diseases Humans Infectious diseases Isoniazid - adverse effects Isoniazid - metabolism Logistic Models Male Medical sciences Middle Aged Mycobacterium Odds Ratio Pharmacogenomics Phenotype Pneumology Polymorphims Polymorphism, Genetic Pyrazinamide - adverse effects Pyrazinamide - metabolism Respiratory system : syndromes and miscellaneous diseases Rifampin - adverse effects Rifampin - metabolism Risk Assessment Risk Factors Tuberculosis Tuberculosis - drug therapy Tuberculosis and atypical mycobacterial infections
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