Defective DNA double-strand break repair in pediatric systemic lupus erythematosus

Objective Previous reports of cells from patients with systemic lupus erythematosus (SLE) note that repair of single‐strand breaks is delayed, and these lesions may be converted to double‐strand breaks (DSBs) at DNA replication forks. We undertook this study to assess the integrity of DSB recognitio...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2012-02, Vol.64 (2), p.568-578
Hauptverfasser:	Davies, Robert C., Pettijohn, Kelly, Fike, Francesca, Wang, Jiexi, Nahas, Shareef A., Tunuguntla, Rashmi, Hu, Hailiang, Gatti, Richard A., McCurdy, Deborah
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Autoimmune diseases Biological and medical sciences Cell Line Child Deoxyribonucleic acid Diseases of the osteoarticular system DNA DNA Breaks, Double-Stranded DNA Repair Female Humans Injuries of the limb. Injuries of the spine Lupus Lupus Erythematosus, Systemic - genetics Male Medical research Medical sciences Pediatrics Phosphorylation Protein expression Proteins S Phase Cell Cycle Checkpoints Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Traumas. Diseases due to physical agents Young Adult
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