A proteomic study of Hutchinson–Gilford progeria syndrome: Application of 2D-chromotography in a premature aging disease

[Display omitted] ► Thirty differentially expressed proteins were identified using PF2D in HGPS cells. ► Thirty differentially expressed proteins were grouped into five categories. ► Expression of cytoskeleton proteins were increased in HGPS fibroblasts. ► Elongated G1/G0 with reduced S phase in the...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-01, Vol.417 (4), p.1119-1126
Hauptverfasser:	Wang, Li, Yang, Wu, Ju, Weina, Wang, Peirong, Zhao, Xinliang, Jenkins, Edmund C., Brown, W. Ted, Zhong, Nanbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging, Premature - genetics Apoptosis - genetics Calcium - metabolism Cell cycle Cell Cycle - genetics Cells, Cultured Chromatography - methods Cytoskeleton - genetics Cytoskeleton - metabolism Cytoskeleton proteins Fibroblasts - metabolism Humans Hutchinson–Gilford progeria syndrome Intracellular calcium Mass spectrum analysis Methylation Progeria - genetics Protein Biosynthesis ProteomeLab™ PF2D Protein Fractionation System Proteomics - methods
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