Rationale and design of a trial on the effect of high dose statins on cardiovascular risk in adults after successful coarctation repair

Abstract Background HMG-coA-reductase-inhibitors (statins) have been proven to reduce atherosclerosis progression as observed by carotid intima-media thickness in patients with known coronary heart disease, independent of lipid lowering. Cardiovascular complications are common in patients after succ...

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Veröffentlicht in:	Contemporary clinical trials 2012-03, Vol.33 (2), p.410-416
Hauptverfasser:	Luijendijk, Paul, Bouma, Berto J, Vriend, Joris W.J, Groenink, Maarten, Vliegen, Hubert W, de Groot, Eric, Pieper, Petronella G, van Dijk, Arie P.J, Sieswerda, Gertjan T, Veen, Gerrit, Zwinderman, Aeilko H, Mulder, Barbara J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aortic coarctation Aortic Coarctation - complications Aortic Coarctation - surgery Atherosclerosis - complications Atherosclerosis - diagnostic imaging Atherosclerosis - drug therapy Atorvastatin Calcium Cardiac Surgical Procedures Cardiovascular Carotid Arteries - diagnostic imaging Carotid intima-media thickness (CIMT) Disease Progression Dose-Response Relationship, Drug Female Follow-Up Studies Hematology, Oncology and Palliative Medicine Heptanoic Acids - administration & dosage History, Ancient HMG-coA-reductase-inhibitors (statins) Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Male Postoperative Care - methods Premature atherosclerosis Prospective Studies Pyrroles - administration & dosage Treatment Outcome Ultrasonography
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