A new approach to manipulate the fate of single neural stem cells in tissue

This study describes a microinjection technique that allows for the acute manipulation of individual neural stem cells in organotypic slice cultures via direct delivery of biologically active molecules. A challenge in the field of neural stem cell biology is the mechanistic dissection of single stem...

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Veröffentlicht in:	Nature neuroscience 2012-02, Vol.15 (2), p.329-337
Hauptverfasser:	Taverna, Elena, Haffner, Christiane, Pepperkok, Rainer, Huttner, Wieland B
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136 631/378/2183/2182 631/378/2571/2579 Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine cdc42 GTP-Binding Protein - administration & dosage cdc42 GTP-Binding Protein - metabolism Cell culture Cell Cycle - drug effects Cell Cycle - genetics Cell Differentiation - genetics Cell Differentiation - physiology Embryo, Mammalian Immediate-Early Proteins - genetics In Vitro Techniques Luminescent Proteins - administration & dosage Luminescent Proteins - genetics Mice Mice, Inbred C57BL Mice, Transgenic Microinjections - methods Mutation - genetics Neural Stem Cells - drug effects Neural Stem Cells - physiology Neurobiology Neurosciences Physiological aspects Rhombencephalon - cytology Rhombencephalon - embryology RNA RNA, Messenger - pharmacology Stem cells technical-report Time Factors Tumor Suppressor Proteins - genetics
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