Molecular Mechanisms Underlying the Time-dependent Autophagy and Apoptosis Induced by Nutrient Depletion in Multiple Myeloma:a Pilot Study

This study explored the molecular mechanisms underlying the time-dependent autophagy and apoptosis induced by nutrient depletion in human multiple myeloma cell line RPMI8226 cells.RT-PCR and qRT-PCR were used to evaluate the transcriptional levels of Deptor,JNK1,JNK2,JNK3,Raf-1,p53,p21 and NFκB1 at...

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Veröffentlicht in:	Journal of Huazhong University of Science and Technology. Medical sciences 2012-02, Vol.32 (1), p.1-8
1. Verfasser:	刘媛陈燕文璐崔国惠
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy c-Jun amino-terminal kinase Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21 - metabolism Humans Intracellular Signaling Peptides and Proteins JNK3 protein MAP Kinase Kinase 4 - metabolism MAP Kinase Signaling System Medicine Medicine & Public Health Molecular modelling multiple Multiple myeloma Multiple Myeloma - complications Multiple Myeloma - metabolism Multiple Myeloma - pathology myeloma RPMI autophagy apoptosis Deptor Raf-/JNK/p/p NFκB NF-kappa B p50 Subunit - metabolism Nutrients Nutrition Disorders - etiology Nutrition Disorders - metabolism p53 protein Phagocytosis Pilot Projects Polymerase chain reaction Proto-Oncogene Proteins c-raf - metabolism Signal transduction Time Factors TOR Serine-Threonine Kinases - metabolism Transcription Tumor cell lines Tumor Suppressor Protein p53 - metabolism
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