Structure, regulation and function of ghrelin

Structure, regulation and function of ghrelin

Ghrelin is a stomach hormone that acts as an endogenous ligand of orphan G-protein-coupled receptor. Ghrelin is a 28-amino acid peptide existing in two major forms: n-octanoyl-modified ghrelin, which possesses an n-octanoyl modification on serine-3 and des-acyl ghrelin. Fatty acid modification of gh...

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Veröffentlicht in:Journal of biochemistry (Tokyo) 2012-02, Vol.151 (2), p.119-128
Hauptverfasser: Sato, Takahiro, Nakamura, Yuki, Shiimura, Yuki, Ohgusu, Hideko, Kangawa, Kenji, Kojima, Masayasu
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
Amino Acid Sequence
Animals
Ghrelin - chemistry
Ghrelin - metabolism
Humans
Molecular Sequence Data
Pituitary Gland - physiology
Pituitary Hormones - metabolism
Structure-Activity Relationship
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container_end_page 128
container_issue 2
container_start_page 119
container_title Journal of biochemistry (Tokyo)
container_volume 151
creator Sato, Takahiro
Nakamura, Yuki
Shiimura, Yuki
Ohgusu, Hideko
Kangawa, Kenji
Kojima, Masayasu
description Ghrelin is a stomach hormone that acts as an endogenous ligand of orphan G-protein-coupled receptor. Ghrelin is a 28-amino acid peptide existing in two major forms: n-octanoyl-modified ghrelin, which possesses an n-octanoyl modification on serine-3 and des-acyl ghrelin. Fatty acid modification of ghrelin is essential for ghrelin-induced growth hormone release from the pituitary and appetite stimulation. This acyl-modification of ghrelin is catalysed by ghrelin-O-acyl transferase recently identified. Despite the number of innovative advancements in this field of research, there are still many aspects of ghrelin function and biosynthesis process that remain to be clarified. Here, we review the current understanding of the structure, regulation and function of ghrelin; this review is intended for researchers who will be involved in this field in the future.
doi_str_mv 10.1093/jb/mvr134
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subjects Acylation
Amino Acid Sequence
Animals
Ghrelin - chemistry
Ghrelin - metabolism
Humans
Molecular Sequence Data
Pituitary Gland - physiology
Pituitary Hormones - metabolism
Structure-Activity Relationship
title Structure, regulation and function of ghrelin
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