Exercise capacity and muscle strength in patients with cirrhosis
Exercise capacity and muscle strength are predictors of outcome in a number of clinical populations. Advanced liver disease is a catabolic state, and patients often have muscle wasting. However, the relationships between exercise capacity, strength, and outcomes for patients undergoing liver transpl...
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| Veröffentlicht in: | Liver transplantation 2012-02, Vol.18 (2), p.146-151 |
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| container_title | Liver transplantation |
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| creator | Jones, Jacqueline C. Coombes, Jeff S. Macdonald, Graeme A. |
| description | Exercise capacity and muscle strength are predictors of outcome in a number of clinical populations. Advanced liver disease is a catabolic state, and patients often have muscle wasting. However, the relationships between exercise capacity, strength, and outcomes for patients undergoing liver transplantation are poorly understood. Thirteen studies have examined the association between these parameters in patients with cirrhosis, and they have found a significant reduction in the exercise capacity and muscle strength of patients with cirrhosis versus healthy controls. These impairments appear to be independent of the etiology of cirrhosis, but the data are equivocal with respect to their association with disease severity. Two studies reported a significant and independent association between pretransplant exercise capacity and posttransplant survival. Another 2 studies found that exercise training was well tolerated in patients with cirrhosis and resulted in improvements in exercise capacity (both studies) and muscle mass (1 study). These data are provocative and suggest that measuring and improving the exercise capacity and muscle strength of patients with cirrhosis who are awaiting liver transplantation could potentially improve outcomes. Liver Transpl 18:146–151, 2012. © 2011 AASLD. |
| doi_str_mv | 10.1002/lt.22472 |
| format | Article |
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Advanced liver disease is a catabolic state, and patients often have muscle wasting. However, the relationships between exercise capacity, strength, and outcomes for patients undergoing liver transplantation are poorly understood. Thirteen studies have examined the association between these parameters in patients with cirrhosis, and they have found a significant reduction in the exercise capacity and muscle strength of patients with cirrhosis versus healthy controls. These impairments appear to be independent of the etiology of cirrhosis, but the data are equivocal with respect to their association with disease severity. Two studies reported a significant and independent association between pretransplant exercise capacity and posttransplant survival. Another 2 studies found that exercise training was well tolerated in patients with cirrhosis and resulted in improvements in exercise capacity (both studies) and muscle mass (1 study). These data are provocative and suggest that measuring and improving the exercise capacity and muscle strength of patients with cirrhosis who are awaiting liver transplantation could potentially improve outcomes. Liver Transpl 18:146–151, 2012. © 2011 AASLD.</description><identifier>ISSN: 1527-6465</identifier><identifier>EISSN: 1527-6473</identifier><identifier>DOI: 10.1002/lt.22472</identifier><identifier>PMID: 22139897</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Blood pressure ; Cirrhosis ; Etiology ; Exercise Therapy ; Exercise Tolerance ; Humans ; Liver ; Liver cirrhosis ; Liver Cirrhosis - complications ; Liver Cirrhosis - physiopathology ; Liver Cirrhosis - surgery ; Liver diseases ; Liver Transplantation ; Muscle Strength ; Muscle Weakness - etiology ; Muscle Weakness - physiopathology ; Muscle, Skeletal - physiopathology ; Recovery of Function ; Studies ; Treatment Outcome ; Waiting Lists</subject><ispartof>Liver transplantation, 2012-02, Vol.18 (2), p.146-151</ispartof><rights>Copyright © 2011 American Association for the Study of Liver Diseases</rights><rights>Copyright © 2011 American Association for the Study of Liver Diseases.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3492-2c420835bf896c4d612358963a4e1804be7dd765f7a38cdf13760d81fcda9e753</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flt.22472$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flt.22472$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22139897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, Jacqueline C.</creatorcontrib><creatorcontrib>Coombes, Jeff S.</creatorcontrib><creatorcontrib>Macdonald, Graeme A.</creatorcontrib><title>Exercise capacity and muscle strength in patients with cirrhosis</title><title>Liver transplantation</title><addtitle>Liver Transpl</addtitle><description>Exercise capacity and muscle strength are predictors of outcome in a number of clinical populations. Advanced liver disease is a catabolic state, and patients often have muscle wasting. However, the relationships between exercise capacity, strength, and outcomes for patients undergoing liver transplantation are poorly understood. Thirteen studies have examined the association between these parameters in patients with cirrhosis, and they have found a significant reduction in the exercise capacity and muscle strength of patients with cirrhosis versus healthy controls. These impairments appear to be independent of the etiology of cirrhosis, but the data are equivocal with respect to their association with disease severity. Two studies reported a significant and independent association between pretransplant exercise capacity and posttransplant survival. Another 2 studies found that exercise training was well tolerated in patients with cirrhosis and resulted in improvements in exercise capacity (both studies) and muscle mass (1 study). These data are provocative and suggest that measuring and improving the exercise capacity and muscle strength of patients with cirrhosis who are awaiting liver transplantation could potentially improve outcomes. Liver Transpl 18:146–151, 2012. © 2011 AASLD.</description><subject>Blood pressure</subject><subject>Cirrhosis</subject><subject>Etiology</subject><subject>Exercise Therapy</subject><subject>Exercise Tolerance</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Liver Cirrhosis - surgery</subject><subject>Liver diseases</subject><subject>Liver Transplantation</subject><subject>Muscle Strength</subject><subject>Muscle Weakness - etiology</subject><subject>Muscle Weakness - physiopathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Recovery of Function</subject><subject>Studies</subject><subject>Treatment Outcome</subject><subject>Waiting Lists</subject><issn>1527-6465</issn><issn>1527-6473</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLAzEUhYMotlbBXyADLlxNzTuTnVLqAwpu6jqkScamzKMmGWr_vdOHXQgXzuHej8vhAHCL4BhBiB-rNMaYCnwGhohhkXMqyPnJczYAVzGuIESISXgJBhgjIgsphuBp-uOC8dFlRq-18Wmb6cZmdRdN5bKYgmu-0jLzTbbWybsmxWzj-4XxISzb6OM1uCh1Fd3NUUfg82U6n7zls4_X98nzLDeESpxjQzEsCFuUheSGWo4wYb0lmjpUQLpwwlrBWSk0KYwtEREc2gKVxmrpBCMj8HD4uw7td-diUrWPxlWVblzbRSVRwQThfEfe_yNXbReaPpxCkvdDaE-OwN2R6ha1s2odfK3DVv1V0wP5Adj4ym1PdwTVrnJVJbWvXM3meyW_HRNw_w</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>Jones, Jacqueline C.</creator><creator>Coombes, Jeff S.</creator><creator>Macdonald, Graeme A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201202</creationdate><title>Exercise capacity and muscle strength in patients with cirrhosis</title><author>Jones, Jacqueline C. ; Coombes, Jeff S. ; Macdonald, Graeme A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3492-2c420835bf896c4d612358963a4e1804be7dd765f7a38cdf13760d81fcda9e753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Blood pressure</topic><topic>Cirrhosis</topic><topic>Etiology</topic><topic>Exercise Therapy</topic><topic>Exercise Tolerance</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Liver Cirrhosis - surgery</topic><topic>Liver diseases</topic><topic>Liver Transplantation</topic><topic>Muscle Strength</topic><topic>Muscle Weakness - etiology</topic><topic>Muscle Weakness - physiopathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Recovery of Function</topic><topic>Studies</topic><topic>Treatment Outcome</topic><topic>Waiting Lists</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, Jacqueline C.</creatorcontrib><creatorcontrib>Coombes, Jeff S.</creatorcontrib><creatorcontrib>Macdonald, Graeme A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Liver transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, Jacqueline C.</au><au>Coombes, Jeff S.</au><au>Macdonald, Graeme A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise capacity and muscle strength in patients with cirrhosis</atitle><jtitle>Liver transplantation</jtitle><addtitle>Liver Transpl</addtitle><date>2012-02</date><risdate>2012</risdate><volume>18</volume><issue>2</issue><spage>146</spage><epage>151</epage><pages>146-151</pages><issn>1527-6465</issn><eissn>1527-6473</eissn><abstract>Exercise capacity and muscle strength are predictors of outcome in a number of clinical populations. Advanced liver disease is a catabolic state, and patients often have muscle wasting. However, the relationships between exercise capacity, strength, and outcomes for patients undergoing liver transplantation are poorly understood. Thirteen studies have examined the association between these parameters in patients with cirrhosis, and they have found a significant reduction in the exercise capacity and muscle strength of patients with cirrhosis versus healthy controls. These impairments appear to be independent of the etiology of cirrhosis, but the data are equivocal with respect to their association with disease severity. Two studies reported a significant and independent association between pretransplant exercise capacity and posttransplant survival. Another 2 studies found that exercise training was well tolerated in patients with cirrhosis and resulted in improvements in exercise capacity (both studies) and muscle mass (1 study). These data are provocative and suggest that measuring and improving the exercise capacity and muscle strength of patients with cirrhosis who are awaiting liver transplantation could potentially improve outcomes. Liver Transpl 18:146–151, 2012. © 2011 AASLD.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22139897</pmid><doi>10.1002/lt.22472</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Blood pressure Cirrhosis Etiology Exercise Therapy Exercise Tolerance Humans Liver Liver cirrhosis Liver Cirrhosis - complications Liver Cirrhosis - physiopathology Liver Cirrhosis - surgery Liver diseases Liver Transplantation Muscle Strength Muscle Weakness - etiology Muscle Weakness - physiopathology Muscle, Skeletal - physiopathology Recovery of Function Studies Treatment Outcome Waiting Lists |
| title | Exercise capacity and muscle strength in patients with cirrhosis |
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