Metabolic activation of furfuryl alcohol: formation of 2-methylfuranyl DNA adducts in Salmonella typhimurium strains expressing human sulfotransferase 1A1 and in FVB/N mice

Furfuryl alcohol, formed by acid- and heat-induced dehydration from pentoses, is found in many foodstuffs. It induced renal tubule neoplasms in male B6C3F1 mice and nasal neoplasms in male F344/N rats in a study of the National Toxicology Program (NTP). However, furfuryl alcohol was negative in the...

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Veröffentlicht in:	Carcinogenesis (New York) 2011-10, Vol.32 (10), p.1533-1539
Hauptverfasser:	Monien, Bernhard H., Herrmann, Kristin, Florian, Simone, Glatt, Hansruedi
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants, Occupational - metabolism Alcoholism and acute alcohol poisoning Ames test Animals Anthracenes Arylsulfotransferase - metabolism Biological and medical sciences Biotransformation Carcinogenesis, carcinogens and anticarcinogens Chromatography, Liquid Deoxyadenosines - chemistry DNA Adducts - metabolism Female Furans - administration & dosage Furans - metabolism Humans Liver - drug effects Liver - enzymology Male Medical sciences Mice Mice, Inbred Strains Mutagenicity Tests Mutagens - toxicity Salmonella typhimurium Salmonella typhimurium - drug effects Salmonella typhimurium - enzymology Salmonella typhimurium - genetics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Swine Toxicology Tumors
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