Enzyme-mediated cross-linking of Pluronic copolymer micelles for injectable and in situ forming hydrogels

A new class of injectable and erodible hydrogels exhibiting highly robust gel strength at body temperature was fabricated by enzyme-mediated cross-linking between Pluronic copolymer micelles. Tyramine-conjugated Pluronic F-127 tri-block copolymers at two terminal ends of polyethylene oxide (PEO) sid...

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Veröffentlicht in:	Acta biomaterialia 2011-04, Vol.7 (4), p.1468-1476
Hauptverfasser:	Lee, Soo Hyeon, Lee, Yuhan, Lee, Sang-Woo, Ji, Ha-Yeun, Lee, Ji-Hee, Lee, Doo Sung, Park, Tae Gwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aqueous solutions bioactive properties body temperature catechol Chromatography, Gel composite polymers Cross-Linking Reagents - metabolism crosslinking dextran drugs Elasticity Enzyme-mediated cross-linking gel strength gelation gels hydrocolloids Hydrogels - chemical synthesis Hydrogels - chemistry Injectable hydrogel Injections Materials Testing Micelles Monophenol Monooxygenase - metabolism Mucins - metabolism Phase Transition Pluronic copolymers Poloxamer - chemistry Poloxamer - metabolism polyethylene glycol Rheology Sol–gel transition Spectrophotometry, Ultraviolet Sus scrofa Tissue-adhesiveness Viscosity
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