FOXM1: From cancer initiation to progression and treatment
The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological processes, including cell proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue homeostasis, angiogenesis and apoptosis. Elevated FOXM1 expression is found in cancers of the...
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| Veröffentlicht in: | Biochimica et biophysica acta 2012, Vol.1819 (1), p.28-37 |
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| creator | Koo, Chuay-Yeng Muir, Kyle W. Lam, Eric W.-F. |
| description | The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological processes, including cell proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue homeostasis, angiogenesis and apoptosis. Elevated FOXM1 expression is found in cancers of the liver, prostate, brain, breast, lung, colon, pancreas, skin, cervix, ovary, mouth, blood and nervous system, suggesting it has an integral role in tumorigenesis. Recent research findings also place FOXM1 at the centre of cancer progression and drug sensitivity. In this review the involvement of FOXM1 in various aspects of cancer, in particular its role and regulation within the context of cancer initiation, progression, and cancer drug response, will be summarised and discussed.
► The FOXM1 transcription factor is a regulator of a broad range of biological processes. ► Elevated and deregulated FOXM1 expression is found in a wide spectrum of cancers. ► FOXM1 also plays a central role in cancer initiation, progression and anti-cancer drug resistance. ► This review summarises the role and regulation of FOXM1 in various aspects of cancer. |
| doi_str_mv | 10.1016/j.bbagrm.2011.09.004 |
| format | Article |
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► The FOXM1 transcription factor is a regulator of a broad range of biological processes. ► Elevated and deregulated FOXM1 expression is found in a wide spectrum of cancers. ► FOXM1 also plays a central role in cancer initiation, progression and anti-cancer drug resistance. ► This review summarises the role and regulation of FOXM1 in various aspects of cancer.</description><identifier>ISSN: 1874-9399</identifier><identifier>ISSN: 0006-3002</identifier><identifier>EISSN: 1876-4320</identifier><identifier>DOI: 10.1016/j.bbagrm.2011.09.004</identifier><identifier>PMID: 21978825</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Cancer ; Cell Movement - genetics ; Cell Proliferation ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - metabolism ; Chemotherapy ; Disease Progression ; Drug Resistance, Neoplasm - genetics ; Forkhead Box Protein M1 ; Forkhead Transcription Factors - genetics ; Forkhead Transcription Factors - metabolism ; FOXM1 ; Function ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasm Invasiveness - genetics ; Neoplasms - genetics ; Neoplasms - pathology ; Neoplasms - therapy ; Regulation</subject><ispartof>Biochimica et biophysica acta, 2012, Vol.1819 (1), p.28-37</ispartof><rights>2011 Elsevier B.V.</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-aad08433cb7e8ec317fcf42dd1730ad2150bda526c942293c9f0a6503c4dd03b3</citedby><cites>FETCH-LOGICAL-c459t-aad08433cb7e8ec317fcf42dd1730ad2150bda526c942293c9f0a6503c4dd03b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1874939911001738$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21978825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koo, Chuay-Yeng</creatorcontrib><creatorcontrib>Muir, Kyle W.</creatorcontrib><creatorcontrib>Lam, Eric W.-F.</creatorcontrib><title>FOXM1: From cancer initiation to progression and treatment</title><title>Biochimica et biophysica acta</title><addtitle>Biochim Biophys Acta</addtitle><description>The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological processes, including cell proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue homeostasis, angiogenesis and apoptosis. Elevated FOXM1 expression is found in cancers of the liver, prostate, brain, breast, lung, colon, pancreas, skin, cervix, ovary, mouth, blood and nervous system, suggesting it has an integral role in tumorigenesis. Recent research findings also place FOXM1 at the centre of cancer progression and drug sensitivity. In this review the involvement of FOXM1 in various aspects of cancer, in particular its role and regulation within the context of cancer initiation, progression, and cancer drug response, will be summarised and discussed.
► The FOXM1 transcription factor is a regulator of a broad range of biological processes. ► Elevated and deregulated FOXM1 expression is found in a wide spectrum of cancers. ► FOXM1 also plays a central role in cancer initiation, progression and anti-cancer drug resistance. ► This review summarises the role and regulation of FOXM1 in various aspects of cancer.</description><subject>Cancer</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Chemotherapy</subject><subject>Disease Progression</subject><subject>Drug Resistance, Neoplasm - genetics</subject><subject>Forkhead Box Protein M1</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Forkhead Transcription Factors - metabolism</subject><subject>FOXM1</subject><subject>Function</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>Regulation</subject><issn>1874-9399</issn><issn>0006-3002</issn><issn>1876-4320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoVqv_QGRvnnadfOxHehCkWBUqvSh4C9lktqR0d2uSCv57t7Z69DQz8L7zzjyEXFHIKNDidpXVtV76NmNAaQYyAxBH5IxWZZEKzuD4pxep5FKOyHkIK4CCMoBTMmJUllXF8jMymS3eX-gkmfm-TYzuDPrEdS46HV3fJbFPNr5fegxhN-rOJtGjji128YKcNHod8PJQx-Rt9vA6fUrni8fn6f08NSKXMdXaQiU4N3WJFRpOy8Y0gllLSw7aMppDbXXOCiMFY5Ib2YAucuBGWAu85mNys987XPKxxRBV64LB9Vp32G-DkrSCQuaiGpRirzS-D8Fjozbetdp_KQpqB02t1B6a2kFTINUAbbBdHwK2dYv2z_RLaRDc7QU4vPnp0KtgHA6srPNoorK9-z_hGxisfnM</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Koo, Chuay-Yeng</creator><creator>Muir, Kyle W.</creator><creator>Lam, Eric W.-F.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>2012</creationdate><title>FOXM1: From cancer initiation to progression and treatment</title><author>Koo, Chuay-Yeng ; Muir, Kyle W. ; Lam, Eric W.-F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-aad08433cb7e8ec317fcf42dd1730ad2150bda526c942293c9f0a6503c4dd03b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Cancer</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Chemotherapy</topic><topic>Disease Progression</topic><topic>Drug Resistance, Neoplasm - genetics</topic><topic>Forkhead Box Protein M1</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>Forkhead Transcription Factors - metabolism</topic><topic>FOXM1</topic><topic>Function</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - therapy</topic><topic>Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koo, Chuay-Yeng</creatorcontrib><creatorcontrib>Muir, Kyle W.</creatorcontrib><creatorcontrib>Lam, Eric W.-F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Biochimica et biophysica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koo, Chuay-Yeng</au><au>Muir, Kyle W.</au><au>Lam, Eric W.-F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FOXM1: From cancer initiation to progression and treatment</atitle><jtitle>Biochimica et biophysica acta</jtitle><addtitle>Biochim Biophys Acta</addtitle><date>2012</date><risdate>2012</risdate><volume>1819</volume><issue>1</issue><spage>28</spage><epage>37</epage><pages>28-37</pages><issn>1874-9399</issn><issn>0006-3002</issn><eissn>1876-4320</eissn><abstract>The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological processes, including cell proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue homeostasis, angiogenesis and apoptosis. Elevated FOXM1 expression is found in cancers of the liver, prostate, brain, breast, lung, colon, pancreas, skin, cervix, ovary, mouth, blood and nervous system, suggesting it has an integral role in tumorigenesis. Recent research findings also place FOXM1 at the centre of cancer progression and drug sensitivity. In this review the involvement of FOXM1 in various aspects of cancer, in particular its role and regulation within the context of cancer initiation, progression, and cancer drug response, will be summarised and discussed.
► The FOXM1 transcription factor is a regulator of a broad range of biological processes. ► Elevated and deregulated FOXM1 expression is found in a wide spectrum of cancers. ► FOXM1 also plays a central role in cancer initiation, progression and anti-cancer drug resistance. ► This review summarises the role and regulation of FOXM1 in various aspects of cancer.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>21978825</pmid><doi>10.1016/j.bbagrm.2011.09.004</doi><tpages>10</tpages></addata></record> |
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| subjects | Cancer Cell Movement - genetics Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Chemotherapy Disease Progression Drug Resistance, Neoplasm - genetics Forkhead Box Protein M1 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FOXM1 Function Gene Expression Regulation, Neoplastic Humans Neoplasm Invasiveness - genetics Neoplasms - genetics Neoplasms - pathology Neoplasms - therapy Regulation |
| title | FOXM1: From cancer initiation to progression and treatment |
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