Modulation of alignment, elongation and contraction of cardiomyocytes through a combination of nanotopography and rigidity of substrates

The topographic and mechanical characteristics of engineered tissue constructs, simulating native tissues, should benefit tissue engineering. Previous studies reported that surface topography and substrate rigidity provide biomechanical cues to modulate cellular responses such as alignment, migratio...

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Veröffentlicht in:	Acta biomaterialia 2011-09, Vol.7 (9), p.3285-3293
Hauptverfasser:	Wang, Peng-Yuan, Yu, Jiashing, Lin, Jia-Hua, Tsai, Wei-Bor
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actins - metabolism adhesion Alignment Animals biocompatible materials biomechanics Cardiomyocyte cardiomyocytes Cell Adhesion Cell Size Contraction Dimethylpolysiloxanes - chemistry Focal Adhesions Materials Testing mechanical properties microfilaments Myocytes, Cardiac - cytology Myocytes, Cardiac - physiology Nanocomposites Nanomaterials Nanostructure Nanotechnology Nanotopography polystyrenes Polystyrenes - chemistry polyurethanes Polyurethanes - chemistry Rats Rigidity Stiffness structural proteins Surface Properties Tissue engineering Tissue Engineering - methods Topography Vinculin - metabolism
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