Topiramate attenuates cerebral ischemia/reperfusion injury in gerbils via activating GABAergic signaling and inhibiting astrogliosis

► Topiramate treatment improved neurological function in gerbils. ► Topiramate evidently attenuated neuronal damage in gerbils by Nissl staining. ► Reduced expressions of apoptosis-regulatory proteins were noted in topiramate group. ► Topiramate treatment obviously decreased expressions of GABAergic...

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Veröffentlicht in:	Neurochemistry international 2012, Vol.60 (1), p.39-46
Hauptverfasser:	Mao, Xiaoyuan, Ji, Changwei, Sun, Chunyan, Cao, Danfeng, Ma, Ping, Ji, Zhong, Cao, Fangyuan, Min, Dongyu, Li, Shuzhi, Cai, Jiqun, Cao, Yonggang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Astrocytes Astrocytes - drug effects Astrocytes - metabolism Astrocytes - pathology Bax protein Bcl-2 protein bcl-2-Associated X Protein - metabolism Biological and medical sciences Brain Ischemia - drug therapy Brain Ischemia - metabolism Carotid artery Caspase-3 Cell death Cell Death - drug effects Chloride transport Fructose - analogs & derivatives Fructose - pharmacology Fructose - therapeutic use Fundamental and applied biological sciences. Psychology GABA receptor gamma -Aminobutyric acid A receptors Gerbillinae GFAP Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism Gliosis Gliosis - metabolism Gliosis - pathology Global cerebral ischemia Hippocampus Hippocampus - drug effects Hippocampus - metabolism Injuries Ischemia KCC2 Male Medical sciences Neurology Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurotransmission NKCC1 Potassium-chloride cotransporter Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, GABA-A - metabolism regulatory proteins Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - pathology Topiramate Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs Western blotting
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