Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin–ruthenium metalla-cubes
Two cationic arene ruthenium metalla-cubes have been evaluated as potential dual photosensitizers and chemotherapeutics. In the dark, the complexes presented good cytotoxicity only towards melanoma and ovarian cancer cells, while the complexes exhibited excellent phototoxicities: The LD50 of the met...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2012-01, Vol.22 (1), p.178-180 |
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| creator | Schmitt, Frédéric Barry, Nicolas P.E. Juillerat-Jeanneret, Lucienne Therrien, Bruno |
| description | Two cationic arene ruthenium metalla-cubes have been evaluated as potential dual photosensitizers and chemotherapeutics. In the dark, the complexes presented good cytotoxicity only towards melanoma and ovarian cancer cells, while the complexes exhibited excellent phototoxicities: The LD50 of the metalla-cubes being between 2 and 7J/cm2. These results suggest a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizers.
Two cationic octanuclear metalla-cubes [Ru8(η6-C6H5Me)8(tpp-H2)2(dhbq)4]8+ and [Ru8(η6-p-iPrC6H4Me)8(tpp-H2)2(dhbq)4]8+ were prepared and evaluated as dual photosensitizers and chemotherapeutics in cancer cells. In the dark, the complexes presented high cytotoxicity towards only melanoma and ovarian cancer cells. However, the complexes exhibited good phototoxicities toward all cancer cells (1μM concentration, LD50=2–7J/cm2), thus suggesting a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizers. |
| doi_str_mv | 10.1016/j.bmcl.2011.11.058 |
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Two cationic octanuclear metalla-cubes [Ru8(η6-C6H5Me)8(tpp-H2)2(dhbq)4]8+ and [Ru8(η6-p-iPrC6H4Me)8(tpp-H2)2(dhbq)4]8+ were prepared and evaluated as dual photosensitizers and chemotherapeutics in cancer cells. In the dark, the complexes presented high cytotoxicity towards only melanoma and ovarian cancer cells. However, the complexes exhibited good phototoxicities toward all cancer cells (1μM concentration, LD50=2–7J/cm2), thus suggesting a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizers.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2011.11.058</identifier><identifier>PMID: 22153934</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Anticancer agents ; Antineoplastic Agents - pharmacology ; Arene ruthenium ; Biological and medical sciences ; Bioorganometallic ; Cations ; Cell Line, Tumor ; chemistry ; chemotherapy ; cytotoxicity ; Dose-Response Relationship, Radiation ; Female ; HeLa Cells ; Humans ; Inhibitory Concentration 50 ; Light ; Medical sciences ; melanoma ; Melanoma - drug therapy ; Metals - chemistry ; Models, Chemical ; Neoplasms - drug therapy ; ovarian neoplasms ; Ovarian Neoplasms - drug therapy ; Pharmacology. Drug treatments ; Photochemistry - methods ; Photochemotherapy - methods ; Photodynamic therapy ; photosensitizing agents ; Photosensitizing Agents - pharmacology ; porphyrins ; Porphyrins - chemistry ; ruthenium ; Ruthenium - chemistry ; Supramolecular assemblies ; synergism ; Time Factors</subject><ispartof>Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.178-180</ispartof><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-7b6a3e5c3e7441f568f493ef9a7c4ee2c677ee93b84f639aaf0f0f84c6afa1723</citedby><cites>FETCH-LOGICAL-c507t-7b6a3e5c3e7441f568f493ef9a7c4ee2c677ee93b84f639aaf0f0f84c6afa1723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2011.11.058$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,4014,27914,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25413290$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22153934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmitt, Frédéric</creatorcontrib><creatorcontrib>Barry, Nicolas P.E.</creatorcontrib><creatorcontrib>Juillerat-Jeanneret, Lucienne</creatorcontrib><creatorcontrib>Therrien, Bruno</creatorcontrib><title>Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin–ruthenium metalla-cubes</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>Two cationic arene ruthenium metalla-cubes have been evaluated as potential dual photosensitizers and chemotherapeutics. In the dark, the complexes presented good cytotoxicity only towards melanoma and ovarian cancer cells, while the complexes exhibited excellent phototoxicities: The LD50 of the metalla-cubes being between 2 and 7J/cm2. These results suggest a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizers.
Two cationic octanuclear metalla-cubes [Ru8(η6-C6H5Me)8(tpp-H2)2(dhbq)4]8+ and [Ru8(η6-p-iPrC6H4Me)8(tpp-H2)2(dhbq)4]8+ were prepared and evaluated as dual photosensitizers and chemotherapeutics in cancer cells. In the dark, the complexes presented high cytotoxicity towards only melanoma and ovarian cancer cells. However, the complexes exhibited good phototoxicities toward all cancer cells (1μM concentration, LD50=2–7J/cm2), thus suggesting a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizers.</description><subject>Anticancer agents</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Arene ruthenium</subject><subject>Biological and medical sciences</subject><subject>Bioorganometallic</subject><subject>Cations</subject><subject>Cell Line, Tumor</subject><subject>chemistry</subject><subject>chemotherapy</subject><subject>cytotoxicity</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Female</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Light</subject><subject>Medical sciences</subject><subject>melanoma</subject><subject>Melanoma - drug therapy</subject><subject>Metals - chemistry</subject><subject>Models, Chemical</subject><subject>Neoplasms - drug therapy</subject><subject>ovarian neoplasms</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Photochemistry - methods</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>photosensitizing agents</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>porphyrins</subject><subject>Porphyrins - chemistry</subject><subject>ruthenium</subject><subject>Ruthenium - chemistry</subject><subject>Supramolecular assemblies</subject><subject>synergism</subject><subject>Time Factors</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAQgC1ERZfCC3CAXBCnLHY8dmKJC6rKj1SJA1TiZjnecderJA52grQ33oE37JPUURa4Vcgj-TDfjMfzEfKC0S2jTL49bNvedtuKMrbNQUXziGwYSCg5UPGYbKiStGwUfD8nT1M6UMqAAjwh51XFBFccNsReOeetx2Eqxn2Ywu44mN7bYtpjNOOxCK6wZrAYizn54bawe-zDmsR5yuAY4rg_Rj_c_fod55wZ_NwXPU6m60xp5xbTM3LmTJfw-em-IDcfrr5dfiqvv3z8fPn-urSC1lNZt9JwFJZjDcCckI0DxdEpU1tArKysa0TF2wac5MoYR_NpwErjDKsrfkHerH3HGH7MmCbd-2QxzzFgmJNWrKESQP4PyTmTDWWZrFbSxpBSRKfH6HsTj5pRvVjQB71Y0IsFnSNbyEUvT-3ntsfd35I_a8_A6xNgkjWdi3nFPv3jBDBeKZq5VyvnTNDmNmbm5mt-SWSVXNSw_OTdSmBe7E-PUafFpsWdj2gnvQv-oUnvAZDSsfQ</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Schmitt, Frédéric</creator><creator>Barry, Nicolas P.E.</creator><creator>Juillerat-Jeanneret, Lucienne</creator><creator>Therrien, Bruno</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20120101</creationdate><title>Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin–ruthenium metalla-cubes</title><author>Schmitt, Frédéric ; Barry, Nicolas P.E. ; Juillerat-Jeanneret, Lucienne ; Therrien, Bruno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-7b6a3e5c3e7441f568f493ef9a7c4ee2c677ee93b84f639aaf0f0f84c6afa1723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anticancer agents</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Arene ruthenium</topic><topic>Biological and medical sciences</topic><topic>Bioorganometallic</topic><topic>Cations</topic><topic>Cell Line, Tumor</topic><topic>chemistry</topic><topic>chemotherapy</topic><topic>cytotoxicity</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Female</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Light</topic><topic>Medical sciences</topic><topic>melanoma</topic><topic>Melanoma - drug therapy</topic><topic>Metals - chemistry</topic><topic>Models, Chemical</topic><topic>Neoplasms - drug therapy</topic><topic>ovarian neoplasms</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Photochemistry - methods</topic><topic>Photochemotherapy - methods</topic><topic>Photodynamic therapy</topic><topic>photosensitizing agents</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>porphyrins</topic><topic>Porphyrins - chemistry</topic><topic>ruthenium</topic><topic>Ruthenium - chemistry</topic><topic>Supramolecular assemblies</topic><topic>synergism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmitt, Frédéric</creatorcontrib><creatorcontrib>Barry, Nicolas P.E.</creatorcontrib><creatorcontrib>Juillerat-Jeanneret, Lucienne</creatorcontrib><creatorcontrib>Therrien, Bruno</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmitt, Frédéric</au><au>Barry, Nicolas P.E.</au><au>Juillerat-Jeanneret, Lucienne</au><au>Therrien, Bruno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin–ruthenium metalla-cubes</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>22</volume><issue>1</issue><spage>178</spage><epage>180</epage><pages>178-180</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>Two cationic arene ruthenium metalla-cubes have been evaluated as potential dual photosensitizers and chemotherapeutics. In the dark, the complexes presented good cytotoxicity only towards melanoma and ovarian cancer cells, while the complexes exhibited excellent phototoxicities: The LD50 of the metalla-cubes being between 2 and 7J/cm2. These results suggest a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizers.
Two cationic octanuclear metalla-cubes [Ru8(η6-C6H5Me)8(tpp-H2)2(dhbq)4]8+ and [Ru8(η6-p-iPrC6H4Me)8(tpp-H2)2(dhbq)4]8+ were prepared and evaluated as dual photosensitizers and chemotherapeutics in cancer cells. In the dark, the complexes presented high cytotoxicity towards only melanoma and ovarian cancer cells. However, the complexes exhibited good phototoxicities toward all cancer cells (1μM concentration, LD50=2–7J/cm2), thus suggesting a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizers.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>22153934</pmid><doi>10.1016/j.bmcl.2011.11.058</doi><tpages>3</tpages></addata></record> |
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| subjects | Anticancer agents Antineoplastic Agents - pharmacology Arene ruthenium Biological and medical sciences Bioorganometallic Cations Cell Line, Tumor chemistry chemotherapy cytotoxicity Dose-Response Relationship, Radiation Female HeLa Cells Humans Inhibitory Concentration 50 Light Medical sciences melanoma Melanoma - drug therapy Metals - chemistry Models, Chemical Neoplasms - drug therapy ovarian neoplasms Ovarian Neoplasms - drug therapy Pharmacology. Drug treatments Photochemistry - methods Photochemotherapy - methods Photodynamic therapy photosensitizing agents Photosensitizing Agents - pharmacology porphyrins Porphyrins - chemistry ruthenium Ruthenium - chemistry Supramolecular assemblies synergism Time Factors |
| title | Efficient photodynamic therapy of cancer using chemotherapeutic porphyrin–ruthenium metalla-cubes |
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