Glycyrrhetinic acid-modified poly(ethylene glycol)–b-poly(γ-benzyl l-glutamate) micelles for liver targeting therapy

Liver targeted micelles were successfully constructed via self-assembly of glycyrrhetinic acid (GA)-modified poly(ethylene glycol)–b-poly(γ-benzyl l-glutamate) (GA–PEG–PBLG) block co-polymers, which were fabricated via ring opening polymerization of γ-benzyl l-glutamate N-carboxyanhydride monomer in...

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Veröffentlicht in:	Acta biomaterialia 2010-10, Vol.6 (10), p.3927-3935
Hauptverfasser:	Huang, Wei, Wang, Wei, Wang, Ping, Tian, Qin, Zhang, Chuangnian, Wang, Chunhong, Yuan, Zhi, Liu, Min, Wan, Haiying, Tang, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - metabolism Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Biocompatible Materials - chemistry Biocompatible Materials - metabolism Block co-polymers Cell Line Doxorubicin Doxorubicin - chemistry Doxorubicin - pharmacology Drug Delivery Systems Female Glycyrrhetinic acid Glycyrrhetinic Acid - chemistry Glycyrrhetinic Acid - metabolism Humans Liver - drug effects Liver - metabolism Liver targeting Materials Testing Micelles Molecular Structure Polyethylene Glycols - chemistry Polyethylene Glycols - metabolism Polyglutamic Acid - chemistry Polyglutamic Acid - metabolism Rats Rats, Wistar Tissue Distribution
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