Biomechanical testing and degradation analysis of MgCa0.8 alloy screws: A comparative in vivo study in rabbits
The aim of this study was to compare the biomechanical properties of degradable magnesium calcium alloy (MgCa0.8) screws and commonly used stainless steel (S316L) screws and to assess the in vivo degradation behavior of MgCa0.8. MgCa0.8 screws (n=48) and S316L screws (n=32) were implanted into both...
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| Veröffentlicht in: | Acta biomaterialia 2011-03, Vol.7 (3), p.1421-1428 |
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| creator | Erdmann, Nina Angrisani, Nina Reifenrath, Janin Lucas, Arne Thorey, Fritz Bormann, Dirk Meyer-Lindenberg, Andrea |
| description | The aim of this study was to compare the biomechanical properties of degradable magnesium calcium alloy (MgCa0.8) screws and commonly used stainless steel (S316L) screws and to assess the in vivo degradation behavior of MgCa0.8. MgCa0.8 screws (n=48) and S316L screws (n=32) were implanted into both tibiae of 40 adult rabbits for a follow-up of 2, 4, 6 and 8weeks. This resulted in a testing group of MgCa0.8 (n=12) and S316L (n=8) screws for each follow-up. Uniaxial pull-out tests were carried out in an MTS 858 Mini Bionix at a rate of 0.1mms−1. For degradation analysis of MgCa0.8 in vivo micro-computed tomography (μCT) was performed to determine the volume of metal alloy remaining. Retrieved MgCa0.8 screws were analysed for degradation by determination of weight changes, scanning electron microscopy and energy dispersive X-ray analyses. No significant differences could be noted between the pull-out forces of MgCa0.8 and S316L 2weeks after surgery (P=0.121). Six weeks after surgery the pull-out force of MgCa0.8 decreased slightly. In contrast, the S316L pull-out force increased with time. Thus, significantly higher pull-out values were detected for S316L from 4weeks on (P |
| doi_str_mv | 10.1016/j.actbio.2010.10.031 |
| format | Article |
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MgCa0.8 screws (n=48) and S316L screws (n=32) were implanted into both tibiae of 40 adult rabbits for a follow-up of 2, 4, 6 and 8weeks. This resulted in a testing group of MgCa0.8 (n=12) and S316L (n=8) screws for each follow-up. Uniaxial pull-out tests were carried out in an MTS 858 Mini Bionix at a rate of 0.1mms−1. For degradation analysis of MgCa0.8 in vivo micro-computed tomography (μCT) was performed to determine the volume of metal alloy remaining. Retrieved MgCa0.8 screws were analysed for degradation by determination of weight changes, scanning electron microscopy and energy dispersive X-ray analyses. No significant differences could be noted between the pull-out forces of MgCa0.8 and S316L 2weeks after surgery (P=0.121). Six weeks after surgery the pull-out force of MgCa0.8 decreased slightly. In contrast, the S316L pull-out force increased with time. Thus, significantly higher pull-out values were detected for S316L from 4weeks on (P<0.001). The volume and weight of MgCa0.8 gradually reduced. A corrosion layer, mainly composed of oxygen, magnesium, calcium and phosphorus, formed on the implants. Since MgCa0.8 showed good biocompatibility and biomechanical properties, comparable with those of S316L in the first 2–3weeks of implantation, its application as a biodegradable implant is conceivable.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2010.10.031</identifier><identifier>PMID: 21050898</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alloys ; Animals ; Biocompatibility ; Biomechanical Phenomena ; Biomechanics ; Biomedical materials ; Calcium - chemistry ; Degradation ; In vivo test ; Magnesium ; Magnesium - chemistry ; Magnesium base alloys ; Mechanical test ; Rabbits ; Scanning electron microscopy ; Screws ; Surgical implants ; Tomography - methods</subject><ispartof>Acta biomaterialia, 2011-03, Vol.7 (3), p.1421-1428</ispartof><rights>2010 Acta Materialia Inc.</rights><rights>Copyright © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-8849b02b5ea6a83a04c9a5f05c5dfdcb89aa9ecdd0dc1410d23baba4b334a3ab3</citedby><cites>FETCH-LOGICAL-c492t-8849b02b5ea6a83a04c9a5f05c5dfdcb89aa9ecdd0dc1410d23baba4b334a3ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1742706110005064$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21050898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erdmann, Nina</creatorcontrib><creatorcontrib>Angrisani, Nina</creatorcontrib><creatorcontrib>Reifenrath, Janin</creatorcontrib><creatorcontrib>Lucas, Arne</creatorcontrib><creatorcontrib>Thorey, Fritz</creatorcontrib><creatorcontrib>Bormann, Dirk</creatorcontrib><creatorcontrib>Meyer-Lindenberg, Andrea</creatorcontrib><title>Biomechanical testing and degradation analysis of MgCa0.8 alloy screws: A comparative in vivo study in rabbits</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>The aim of this study was to compare the biomechanical properties of degradable magnesium calcium alloy (MgCa0.8) screws and commonly used stainless steel (S316L) screws and to assess the in vivo degradation behavior of MgCa0.8. MgCa0.8 screws (n=48) and S316L screws (n=32) were implanted into both tibiae of 40 adult rabbits for a follow-up of 2, 4, 6 and 8weeks. This resulted in a testing group of MgCa0.8 (n=12) and S316L (n=8) screws for each follow-up. Uniaxial pull-out tests were carried out in an MTS 858 Mini Bionix at a rate of 0.1mms−1. For degradation analysis of MgCa0.8 in vivo micro-computed tomography (μCT) was performed to determine the volume of metal alloy remaining. Retrieved MgCa0.8 screws were analysed for degradation by determination of weight changes, scanning electron microscopy and energy dispersive X-ray analyses. No significant differences could be noted between the pull-out forces of MgCa0.8 and S316L 2weeks after surgery (P=0.121). Six weeks after surgery the pull-out force of MgCa0.8 decreased slightly. In contrast, the S316L pull-out force increased with time. Thus, significantly higher pull-out values were detected for S316L from 4weeks on (P<0.001). The volume and weight of MgCa0.8 gradually reduced. A corrosion layer, mainly composed of oxygen, magnesium, calcium and phosphorus, formed on the implants. Since MgCa0.8 showed good biocompatibility and biomechanical properties, comparable with those of S316L in the first 2–3weeks of implantation, its application as a biodegradable implant is conceivable.</description><subject>Alloys</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Biomedical materials</subject><subject>Calcium - chemistry</subject><subject>Degradation</subject><subject>In vivo test</subject><subject>Magnesium</subject><subject>Magnesium - chemistry</subject><subject>Magnesium base alloys</subject><subject>Mechanical test</subject><subject>Rabbits</subject><subject>Scanning electron microscopy</subject><subject>Screws</subject><subject>Surgical implants</subject><subject>Tomography - methods</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuP0zAQgC0EYh_wDxDyDS4J49hJbA5IS8UC0iIucLbGjxRXSVzstKj_HocuHJfTPPTNjOyPkBcMagase7Or0S4mxLqBP60aOHtELpnsZdW3nXxc8l40VQ8duyBXOe8AuGSNfEouGgYtSCUvyfw-xMnbHzgHiyNdfF7CvKU4O-r8NqHDJcS51Diecsg0DvTLdoNQS4rjGE802-R_5bf0hto47TEV_uhpmOkxHCPNy8Gd1iqhMWHJz8iTAcfsn9_Ha_L99sO3zafq7uvHz5ubu8oK1SyVlEIZaEzrsUPJEYRV2A7Q2tYNzhqpEJW3zoGzTDBwDTdoUBjOBXI0_Jq8Ou_dp_jzUB6lp5CtH0ecfTxkrZiEToCC_5JSyE62TLWFfP0gybqe8b7v-LpUnFGbYs7JD3qfwoTppBno1Z7e6bM9vdpbu8VeGXt5f-FgJu_-Df3VVYB3Z8CXvzsGn3S2wc_Wu5C8XbSL4eELvwFwpa3M</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Erdmann, Nina</creator><creator>Angrisani, Nina</creator><creator>Reifenrath, Janin</creator><creator>Lucas, Arne</creator><creator>Thorey, Fritz</creator><creator>Bormann, Dirk</creator><creator>Meyer-Lindenberg, Andrea</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7SE</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>7QO</scope><scope>P64</scope></search><sort><creationdate>20110301</creationdate><title>Biomechanical testing and degradation analysis of MgCa0.8 alloy screws: A comparative in vivo study in rabbits</title><author>Erdmann, Nina ; Angrisani, Nina ; Reifenrath, Janin ; Lucas, Arne ; Thorey, Fritz ; Bormann, Dirk ; Meyer-Lindenberg, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-8849b02b5ea6a83a04c9a5f05c5dfdcb89aa9ecdd0dc1410d23baba4b334a3ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Alloys</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>Biomechanical Phenomena</topic><topic>Biomechanics</topic><topic>Biomedical materials</topic><topic>Calcium - chemistry</topic><topic>Degradation</topic><topic>In vivo test</topic><topic>Magnesium</topic><topic>Magnesium - chemistry</topic><topic>Magnesium base alloys</topic><topic>Mechanical test</topic><topic>Rabbits</topic><topic>Scanning electron microscopy</topic><topic>Screws</topic><topic>Surgical implants</topic><topic>Tomography - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erdmann, Nina</creatorcontrib><creatorcontrib>Angrisani, Nina</creatorcontrib><creatorcontrib>Reifenrath, Janin</creatorcontrib><creatorcontrib>Lucas, Arne</creatorcontrib><creatorcontrib>Thorey, Fritz</creatorcontrib><creatorcontrib>Bormann, Dirk</creatorcontrib><creatorcontrib>Meyer-Lindenberg, Andrea</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erdmann, Nina</au><au>Angrisani, Nina</au><au>Reifenrath, Janin</au><au>Lucas, Arne</au><au>Thorey, Fritz</au><au>Bormann, Dirk</au><au>Meyer-Lindenberg, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomechanical testing and degradation analysis of MgCa0.8 alloy screws: A comparative in vivo study in rabbits</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>7</volume><issue>3</issue><spage>1421</spage><epage>1428</epage><pages>1421-1428</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>The aim of this study was to compare the biomechanical properties of degradable magnesium calcium alloy (MgCa0.8) screws and commonly used stainless steel (S316L) screws and to assess the in vivo degradation behavior of MgCa0.8. MgCa0.8 screws (n=48) and S316L screws (n=32) were implanted into both tibiae of 40 adult rabbits for a follow-up of 2, 4, 6 and 8weeks. This resulted in a testing group of MgCa0.8 (n=12) and S316L (n=8) screws for each follow-up. Uniaxial pull-out tests were carried out in an MTS 858 Mini Bionix at a rate of 0.1mms−1. For degradation analysis of MgCa0.8 in vivo micro-computed tomography (μCT) was performed to determine the volume of metal alloy remaining. Retrieved MgCa0.8 screws were analysed for degradation by determination of weight changes, scanning electron microscopy and energy dispersive X-ray analyses. No significant differences could be noted between the pull-out forces of MgCa0.8 and S316L 2weeks after surgery (P=0.121). Six weeks after surgery the pull-out force of MgCa0.8 decreased slightly. In contrast, the S316L pull-out force increased with time. Thus, significantly higher pull-out values were detected for S316L from 4weeks on (P<0.001). The volume and weight of MgCa0.8 gradually reduced. A corrosion layer, mainly composed of oxygen, magnesium, calcium and phosphorus, formed on the implants. Since MgCa0.8 showed good biocompatibility and biomechanical properties, comparable with those of S316L in the first 2–3weeks of implantation, its application as a biodegradable implant is conceivable.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>21050898</pmid><doi>10.1016/j.actbio.2010.10.031</doi><tpages>8</tpages></addata></record> |
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| ispartof | Acta biomaterialia, 2011-03, Vol.7 (3), p.1421-1428 |
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| subjects | Alloys Animals Biocompatibility Biomechanical Phenomena Biomechanics Biomedical materials Calcium - chemistry Degradation In vivo test Magnesium Magnesium - chemistry Magnesium base alloys Mechanical test Rabbits Scanning electron microscopy Screws Surgical implants Tomography - methods |
| title | Biomechanical testing and degradation analysis of MgCa0.8 alloy screws: A comparative in vivo study in rabbits |
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