Solvent-free functionalization of silicone rubber and efficacy of PAAm brushes grafted from an amino-PPX layer against bacterial adhesion
Silicone rubber is a frequently employed biomaterial that is prone to bacterial adhesion and biofilm formation. In this study, the surface of silicone rubber was solvent-free functionalized by chemical vapor deposition (CVD) of poly( o-amino- p-xylylene- co- p-xylylene (amino-PPX). Subsequently, the...
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| Veröffentlicht in: | Acta biomaterialia 2010-11, Vol.6 (11), p.4271-4276 |
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| creator | Fundeanu, Irina Klee, Doris Schouten, Arend J. Busscher, Henk J. van der Mei, Henny C. |
| description | Silicone rubber is a frequently employed biomaterial that is prone to bacterial adhesion and biofilm formation. In this study, the surface of silicone rubber was solvent-free functionalized by chemical vapor deposition (CVD) of poly(
o-amino-
p-xylylene-
co-
p-xylylene (amino-PPX). Subsequently, the amino groups of the amino-PPX layer were used to introduce the initiator from a vapor phase for atom transfer radical polymerization of acrylamide to form polyacrylamide (PAAm) brushes. The modification steps were verified by means of X-ray photoelectron spectroscopy and attenuated total reflection–Fourier transform infrared spectroscopy. Adhesion of
Staphylococcus aureus ATCC 12600 and
Escherichia coli 3.14 to an amino-PPX–PAAm brush coating in a parallel plate flow chamber was strongly reduced with respect to non-coated silicone rubber – by 93% and 99%, respectively. For
E. coli 3.14, this reduction is larger than that obtained for solvent functionalization of γ-aminopropyltriethoxysilane–PAAm brushes due to the higher density of amino groups introduced by the CVD of amino-PPX. |
| doi_str_mv | 10.1016/j.actbio.2010.06.010 |
| format | Article |
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o-amino-
p-xylylene-
co-
p-xylylene (amino-PPX). Subsequently, the amino groups of the amino-PPX layer were used to introduce the initiator from a vapor phase for atom transfer radical polymerization of acrylamide to form polyacrylamide (PAAm) brushes. The modification steps were verified by means of X-ray photoelectron spectroscopy and attenuated total reflection–Fourier transform infrared spectroscopy. Adhesion of
Staphylococcus aureus ATCC 12600 and
Escherichia coli 3.14 to an amino-PPX–PAAm brush coating in a parallel plate flow chamber was strongly reduced with respect to non-coated silicone rubber – by 93% and 99%, respectively. For
E. coli 3.14, this reduction is larger than that obtained for solvent functionalization of γ-aminopropyltriethoxysilane–PAAm brushes due to the higher density of amino groups introduced by the CVD of amino-PPX.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2010.06.010</identifier><identifier>PMID: 20558329</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acrylic Resins - chemistry ; Acrylic Resins - pharmacology ; Aniline Compounds - chemistry ; Bacterial adhesion ; Bacterial Adhesion - drug effects ; Escherichia coli ; Escherichia coli - cytology ; Escherichia coli - drug effects ; Kinetics ; Photoelectron Spectroscopy ; Poly( o-amino- p-xylylene- co- p-xylylene) ; Polyacrylamide brushes ; Polymers - chemistry ; Silicone Elastomers - chemistry ; Solvent-free functionalization of silicone rubber ; Solvents - chemistry ; Solvents - pharmacology ; Spectroscopy, Fourier Transform Infrared ; Staphylococcus aureus ; Staphylococcus aureus - cytology ; Staphylococcus aureus - drug effects ; Surface Properties - drug effects ; Time Factors ; γ-Aminopropyltriethoxysilane</subject><ispartof>Acta biomaterialia, 2010-11, Vol.6 (11), p.4271-4276</ispartof><rights>2010 Acta Materialia Inc.</rights><rights>Copyright © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-11e2b965b12fa045bb96a0ba321e6a7a58a6b792c38c07ed85a8a219f5a782343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actbio.2010.06.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20558329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fundeanu, Irina</creatorcontrib><creatorcontrib>Klee, Doris</creatorcontrib><creatorcontrib>Schouten, Arend J.</creatorcontrib><creatorcontrib>Busscher, Henk J.</creatorcontrib><creatorcontrib>van der Mei, Henny C.</creatorcontrib><title>Solvent-free functionalization of silicone rubber and efficacy of PAAm brushes grafted from an amino-PPX layer against bacterial adhesion</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>Silicone rubber is a frequently employed biomaterial that is prone to bacterial adhesion and biofilm formation. In this study, the surface of silicone rubber was solvent-free functionalized by chemical vapor deposition (CVD) of poly(
o-amino-
p-xylylene-
co-
p-xylylene (amino-PPX). Subsequently, the amino groups of the amino-PPX layer were used to introduce the initiator from a vapor phase for atom transfer radical polymerization of acrylamide to form polyacrylamide (PAAm) brushes. The modification steps were verified by means of X-ray photoelectron spectroscopy and attenuated total reflection–Fourier transform infrared spectroscopy. Adhesion of
Staphylococcus aureus ATCC 12600 and
Escherichia coli 3.14 to an amino-PPX–PAAm brush coating in a parallel plate flow chamber was strongly reduced with respect to non-coated silicone rubber – by 93% and 99%, respectively. For
E. coli 3.14, this reduction is larger than that obtained for solvent functionalization of γ-aminopropyltriethoxysilane–PAAm brushes due to the higher density of amino groups introduced by the CVD of amino-PPX.</description><subject>Acrylic Resins - chemistry</subject><subject>Acrylic Resins - pharmacology</subject><subject>Aniline Compounds - chemistry</subject><subject>Bacterial adhesion</subject><subject>Bacterial Adhesion - drug effects</subject><subject>Escherichia coli</subject><subject>Escherichia coli - cytology</subject><subject>Escherichia coli - drug effects</subject><subject>Kinetics</subject><subject>Photoelectron Spectroscopy</subject><subject>Poly( o-amino- p-xylylene- co- p-xylylene)</subject><subject>Polyacrylamide brushes</subject><subject>Polymers - chemistry</subject><subject>Silicone Elastomers - chemistry</subject><subject>Solvent-free functionalization of silicone rubber</subject><subject>Solvents - chemistry</subject><subject>Solvents - pharmacology</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - cytology</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Surface Properties - drug effects</subject><subject>Time Factors</subject><subject>γ-Aminopropyltriethoxysilane</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhSMEoj_wBgh5xyoX24l_skG6qgpUqsSVWiR21tgZF18lcbGTSpc34K1xdAvLdjVj-ztzrDlV9Y7RDaNMftxvwM02xA2n5YrKTSkvqlOmla6VkPpl6VXLa0UlO6nOct5T2mjG9evqhFMhdMO70-rPTRwecJprnxCJXyY3hzjBEH7D2pDoSQ5DcHFCkhZrMRGYeoLeBwfusL7vttuR2LTkn5jJXQI_Y098imMhCYxhivVu94MMcFjFdxCmPBNbPo8pwECgL7pi9aZ65WHI-PaxnlffP1_eXnytr799ubrYXteu6Zq5Zgy57aSwjHugrbDlANRCwxlKUCA0SKs67hrtqMJeC9DAWecFKM2btjmvPhzn3qf4a8E8mzFkh8MAE8Ylm45pKlta9vMcqYRginZKFrI9ki7FnBN6c5_CCOlgGDVrWmZvjmmZNS1DpSmlyN4_Gix2xP6_6F88Bfh0BLAs5CFgMtkFnBz2IaGbTR_D0w5_AZLXqSU</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Fundeanu, Irina</creator><creator>Klee, Doris</creator><creator>Schouten, Arend J.</creator><creator>Busscher, Henk J.</creator><creator>van der Mei, Henny C.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20101101</creationdate><title>Solvent-free functionalization of silicone rubber and efficacy of PAAm brushes grafted from an amino-PPX layer against bacterial adhesion</title><author>Fundeanu, Irina ; Klee, Doris ; Schouten, Arend J. ; Busscher, Henk J. ; van der Mei, Henny C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-11e2b965b12fa045bb96a0ba321e6a7a58a6b792c38c07ed85a8a219f5a782343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acrylic Resins - chemistry</topic><topic>Acrylic Resins - pharmacology</topic><topic>Aniline Compounds - chemistry</topic><topic>Bacterial adhesion</topic><topic>Bacterial Adhesion - drug effects</topic><topic>Escherichia coli</topic><topic>Escherichia coli - cytology</topic><topic>Escherichia coli - drug effects</topic><topic>Kinetics</topic><topic>Photoelectron Spectroscopy</topic><topic>Poly( o-amino- p-xylylene- co- p-xylylene)</topic><topic>Polyacrylamide brushes</topic><topic>Polymers - chemistry</topic><topic>Silicone Elastomers - chemistry</topic><topic>Solvent-free functionalization of silicone rubber</topic><topic>Solvents - chemistry</topic><topic>Solvents - pharmacology</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - cytology</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Surface Properties - drug effects</topic><topic>Time Factors</topic><topic>γ-Aminopropyltriethoxysilane</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fundeanu, Irina</creatorcontrib><creatorcontrib>Klee, Doris</creatorcontrib><creatorcontrib>Schouten, Arend J.</creatorcontrib><creatorcontrib>Busscher, Henk J.</creatorcontrib><creatorcontrib>van der Mei, Henny C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fundeanu, Irina</au><au>Klee, Doris</au><au>Schouten, Arend J.</au><au>Busscher, Henk J.</au><au>van der Mei, Henny C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solvent-free functionalization of silicone rubber and efficacy of PAAm brushes grafted from an amino-PPX layer against bacterial adhesion</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>6</volume><issue>11</issue><spage>4271</spage><epage>4276</epage><pages>4271-4276</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>Silicone rubber is a frequently employed biomaterial that is prone to bacterial adhesion and biofilm formation. In this study, the surface of silicone rubber was solvent-free functionalized by chemical vapor deposition (CVD) of poly(
o-amino-
p-xylylene-
co-
p-xylylene (amino-PPX). Subsequently, the amino groups of the amino-PPX layer were used to introduce the initiator from a vapor phase for atom transfer radical polymerization of acrylamide to form polyacrylamide (PAAm) brushes. The modification steps were verified by means of X-ray photoelectron spectroscopy and attenuated total reflection–Fourier transform infrared spectroscopy. Adhesion of
Staphylococcus aureus ATCC 12600 and
Escherichia coli 3.14 to an amino-PPX–PAAm brush coating in a parallel plate flow chamber was strongly reduced with respect to non-coated silicone rubber – by 93% and 99%, respectively. For
E. coli 3.14, this reduction is larger than that obtained for solvent functionalization of γ-aminopropyltriethoxysilane–PAAm brushes due to the higher density of amino groups introduced by the CVD of amino-PPX.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>20558329</pmid><doi>10.1016/j.actbio.2010.06.010</doi><tpages>6</tpages></addata></record> |
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| subjects | Acrylic Resins - chemistry Acrylic Resins - pharmacology Aniline Compounds - chemistry Bacterial adhesion Bacterial Adhesion - drug effects Escherichia coli Escherichia coli - cytology Escherichia coli - drug effects Kinetics Photoelectron Spectroscopy Poly( o-amino- p-xylylene- co- p-xylylene) Polyacrylamide brushes Polymers - chemistry Silicone Elastomers - chemistry Solvent-free functionalization of silicone rubber Solvents - chemistry Solvents - pharmacology Spectroscopy, Fourier Transform Infrared Staphylococcus aureus Staphylococcus aureus - cytology Staphylococcus aureus - drug effects Surface Properties - drug effects Time Factors γ-Aminopropyltriethoxysilane |
| title | Solvent-free functionalization of silicone rubber and efficacy of PAAm brushes grafted from an amino-PPX layer against bacterial adhesion |
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