Long-term Vaccine Therapy with Autologous Whole Tumor Cell-pulsed Dendritic Cells for a Patient with Recurrent Rectal Carcinoma

We performed continuous dendritic cells (DCs) vaccination to treat a patient with chemotherapy-resistant recurrent rectal carcinoma and lung and bone metastases. A patient has received a total of 66 DC vaccinations at 14-day intervals for 3 years until his death. Necrotic whole tumor cells (WTC) wer...

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Veröffentlicht in:	Anticancer research 2011-11, Vol.31 (11), p.3995-4005
Hauptverfasser:	ONISHI, Hideya, MORISAKI, Takashi, BABA, Eishi, NAKAMURA, Mitsunari, INABA, Syoichi, KUROKI, Hideo, MATSUMOTO, Kotaro, KATANO, Mitsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, Neoplasm - immunology Biological and medical sciences Blotting, Western Bone Neoplasms - immunology Bone Neoplasms - secondary Bone Neoplasms - therapy Cancer Vaccines - therapeutic use Cell Line, Tumor Dendritic Cells - immunology Enzyme-Linked Immunosorbent Assay Flow Cytometry Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Immunotherapy, Active Interferon-gamma - metabolism Interleukin-12 - genetics Interleukin-12 - metabolism Lung Neoplasms - immunology Lung Neoplasms - secondary Lung Neoplasms - therapy Male Medical sciences Neoplasm Recurrence, Local - immunology Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - therapy Rectal Neoplasms - immunology Rectal Neoplasms - pathology Rectal Neoplasms - therapy Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology Tumors Vaccination
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