Characterization of potential elastase inhibitor-peptides regulated by a molecular switch for wound dressings applications

► A peptide library was designed using peptide sequences derived from endogenous proteins. ► The screening of the library in a microarray format identified a robust hit, Pep4. ► Phosphorylation of Pep4 and Pep4M reduces their inhibitory activity towards elastase. ► Differential inhibition by phospho...

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Veröffentlicht in:	Enzyme and microbial technology 2012-02, Vol.50 (2), p.107-114
Hauptverfasser:	Barros, Sandra Cerqueira, Martins, José Alberto, Marcos, João Carlos, Cavaco-Paulo, Artur
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bandages Biotechnology - methods Casein Kinase Idelta - metabolism cysteine dephosphorylation Elastase Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Gene Expression Regulation Humans Inhibitor-peptides Luminometry methionine Micro-arrays microarray technology neutrophils non-specific serine/threonine protein kinase Oligonucleotide Array Sequence Analysis Oligopeptides - metabolism Pancreatic Elastase - antagonists & inhibitors Pancreatic Elastase - metabolism peptide libraries Peptide Library Peptides - chemistry Peptides - metabolism Phosphorylation Substrate Specificity tissue repair Wound dressings Wound Healing
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