Antibody-Mediated Osseous Regeneration: A Novel Strategy for Bioengineering Bone by Immobilized Anti–Bone Morphogenetic Protein-2 Antibodies

Bone regeneration often requires harvesting of autologous bone with significant potential morbidity and cost. Recombinant human bone morphogenetic protein (rhBMP)-2 has been approved by the U.S. Food and Drug Administration for specific regenerative indications. However, administration of exogenous...

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Veröffentlicht in:	Tissue engineering. Part A 2011-12, Vol.17 (23-24), p.2911-2918
Hauptverfasser:	Freire, Marcelo O., You, Huyng-Keun, Kook, Joong-Ki, Choi, Jeong-Ho, Zadeh, Homayoun H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - pharmacology Bioengineering Bioengineering - methods Bone and Bones - diagnostic imaging Bone and Bones - drug effects Bone and Bones - physiology Bone Morphogenetic Protein 2 - immunology Bone Regeneration - drug effects Bones Cell Line Flow Cytometry Humans Immobilized Proteins - pharmacology Immunohistochemistry Implants, Experimental Mice Monoclonal antibodies Original Articles Osteocalcin - metabolism Protein Binding - drug effects Proteins Rats Recombinant Proteins - immunology Skull - diagnostic imaging Skull - drug effects Skull - pathology Tissue engineering Transforming Growth Factor beta - immunology X-Ray Microtomography
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