Effects of amphiphilic PCL–PEG–PCL copolymer addition on 5-fluorouracil release from biodegradable PCL films for stent application

Biodegradable film-based stents emerged as a promising medical platform for drug delivery to resolve stenosis encountered in physiological conduits (e.g. blood vessels, biliary and urethral tracts). Drug release kinetics significantly affects the pharmacological effects of a stent, thus it is desira...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of pharmaceutics 2011-10, Vol.419 (1), p.77-84
Hauptverfasser:	Lu, Fei, Lei, Lei, Shen, Yuan-Yuan, Hou, Jing-Wen, Chen, Wei-Luan, Li, Yang-Gong, Guo, Sheng-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil additives Antimetabolites, Antineoplastic - administration & dosage Biodegradability Biological and medical sciences Blood vessels composite polymers Copolymers Crystallization Diffusion tests Drug Carriers - chemistry Drug delivery Drug-Eluting Stents drugs ethylene glycol Fluorouracil - administration & dosage General pharmacology Implants In vitro drug release Kinetics Medical sciences PCL–PEG–PCL Permeability Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly(ɛ-caprolactone) Polyesters - chemistry Polyethylene Glycols - chemistry Stenosis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!