P115 Chronic Diesel Exhaust Particle (DEP) exposure differentially alters monocyte differentiation and function in healthy controls compared to COPD

Introduction and ObjectivesAlveolar macrophages are heavily implicated in the pathogenesis COPD. During chronic inflammation, macrophages mature continuously from infiltrating monocytes that are continually recruited to the airways. We have previously found DEP modulate life span and function of mon...

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Veröffentlicht in:Thorax 2011-12, Vol.66 (Suppl 4), p.A114-A114
Hauptverfasser: Chaudhuri, N, Jary, H, Lea, S, Khan, N, Parker, L C, Singh, D, Sabroe, I
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Sprache:eng
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