Biological Mechanism for the Toxicity of Haloacetic Acid Drinking Water Disinfection Byproducts

The halogenated acetic acids are a major class of drinking water disinfection byproducts (DBPs) with five haloacetic acids regulated by the U.S. EPA. These agents are cytotoxic, genotoxic, mutagenic, and teratogenic. The decreasing toxicity rank order of the monohalogenated acetic acids (monoHAAs) i...

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Veröffentlicht in:	Environmental science & technology 2011-07, Vol.45 (13), p.5791-5797
Hauptverfasser:	Pals, Justin A, Ang, Justin K, Wagner, Elizabeth D, Plewa, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - metabolism Acetates - toxicity Acids Animals Applied sciences Biological and medical sciences By products CHO Cells Cricetinae Cricetulus Disinfectants - metabolism Disinfectants - toxicity Disinfection & disinfectants DNA Damage Drinking water Ecotoxicology and Human Environmental Health Electrophoresis Epidemiology. Vaccinations Exact sciences and technology General aspects Glyceraldehyde-3-Phosphate Dehydrogenases - antagonists & inhibitors Glycolysis - drug effects Halogenation Infectious diseases Kinetics Medical sciences Models, Biological Molecular Structure Pollution Toxicity Toxicity Tests - methods Water Supply - standards
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