Resistance phenotypes and genotypes of Streptococcus pyogenes clinical isolates in Chile over a 10-year period
Macrolide and lincosamide resistance in Streptococcus pyogenes is due to the acquisition of mef, ermB and ermA genes, which confer different resistance phenotypes, namely M, MLSBconstitutive and MLSBinducible respectively. The last report of resistance in Chile was done in the period 1990-1998, in w...
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| Veröffentlicht in: | Revista medíca de Chile 2011-09, Vol.139 (9), p.1143-1149 |
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| creator | Rodríguez, Carlos Rojas, Pablo Wozniak, Aniela Kalergis, Alexis M Cerón, Inés Riedel, Ingrid Román, Juan C Villarroel, Luis A Berríos, Ximena Bavestrello, Luis García, Patricia |
| description | Macrolide and lincosamide resistance in Streptococcus pyogenes is due to the acquisition of mef, ermB and ermA genes, which confer different resistance phenotypes, namely M, MLSBconstitutive and MLSBinducible respectively. The last report of resistance in Chile was done in the period 1990-1998, in which resistance to macrolides was 5.4%, with M phenotype as the predominant one.
To characterize the evolution of erythromycin and clindamycin resistance and their associated genes in S. pyogenes strains isolated from patients with invasive and non-invasive infections in the period 1996 to 2005.
Resistance to erythromycin and clindamycin was determined in 1,282 clinical isolates using the disk diffusion test. Resistant isolates were analyzed by polymerase chain reaction (PCR) for the presence of the above mentioned resistance genes.
Global resistance to erythromycin and clindamycin was 3.5 and 0.7% respectively. Eighty percent of the resistant strains possessed the M. phenotype.
Resistance levels of S. pyogenes have decreased in Chile in the last years. Most resistant strains have M phenotype in contrast to many countries in which the MLSB constitutive phenotype is the predominant one. |
| doi_str_mv | 10.4067/S0034-98872011000900005 |
| format | Article |
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To characterize the evolution of erythromycin and clindamycin resistance and their associated genes in S. pyogenes strains isolated from patients with invasive and non-invasive infections in the period 1996 to 2005.
Resistance to erythromycin and clindamycin was determined in 1,282 clinical isolates using the disk diffusion test. Resistant isolates were analyzed by polymerase chain reaction (PCR) for the presence of the above mentioned resistance genes.
Global resistance to erythromycin and clindamycin was 3.5 and 0.7% respectively. Eighty percent of the resistant strains possessed the M. phenotype.
Resistance levels of S. pyogenes have decreased in Chile in the last years. Most resistant strains have M phenotype in contrast to many countries in which the MLSB constitutive phenotype is the predominant one.</description><identifier>ISSN: 0034-9887</identifier><identifier>EISSN: 0717-6163</identifier><identifier>DOI: 10.4067/S0034-98872011000900005</identifier><identifier>PMID: 22215392</identifier><language>spa</language><publisher>Chile</publisher><subject>Anti-Bacterial Agents - pharmacology ; Bacterial Proteins - genetics ; Chile - epidemiology ; Clindamycin - pharmacology ; Drug Resistance, Bacterial - drug effects ; Drug Resistance, Bacterial - genetics ; Erythromycin - pharmacology ; Genotype ; Humans ; Membrane Proteins - genetics ; Methyltransferases - genetics ; Pharyngitis - drug therapy ; Pharyngitis - microbiology ; Phenotype ; Poisson Distribution ; Streptococcal Infections - drug therapy ; Streptococcal Infections - microbiology ; Streptococcus pyogenes ; Streptococcus pyogenes - drug effects ; Streptococcus pyogenes - genetics</subject><ispartof>Revista medíca de Chile, 2011-09, Vol.139 (9), p.1143-1149</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22215392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodríguez, Carlos</creatorcontrib><creatorcontrib>Rojas, Pablo</creatorcontrib><creatorcontrib>Wozniak, Aniela</creatorcontrib><creatorcontrib>Kalergis, Alexis M</creatorcontrib><creatorcontrib>Cerón, Inés</creatorcontrib><creatorcontrib>Riedel, Ingrid</creatorcontrib><creatorcontrib>Román, Juan C</creatorcontrib><creatorcontrib>Villarroel, Luis A</creatorcontrib><creatorcontrib>Berríos, Ximena</creatorcontrib><creatorcontrib>Bavestrello, Luis</creatorcontrib><creatorcontrib>García, Patricia</creatorcontrib><title>Resistance phenotypes and genotypes of Streptococcus pyogenes clinical isolates in Chile over a 10-year period</title><title>Revista medíca de Chile</title><addtitle>Rev Med Chil</addtitle><description>Macrolide and lincosamide resistance in Streptococcus pyogenes is due to the acquisition of mef, ermB and ermA genes, which confer different resistance phenotypes, namely M, MLSBconstitutive and MLSBinducible respectively. The last report of resistance in Chile was done in the period 1990-1998, in which resistance to macrolides was 5.4%, with M phenotype as the predominant one.
To characterize the evolution of erythromycin and clindamycin resistance and their associated genes in S. pyogenes strains isolated from patients with invasive and non-invasive infections in the period 1996 to 2005.
Resistance to erythromycin and clindamycin was determined in 1,282 clinical isolates using the disk diffusion test. Resistant isolates were analyzed by polymerase chain reaction (PCR) for the presence of the above mentioned resistance genes.
Global resistance to erythromycin and clindamycin was 3.5 and 0.7% respectively. Eighty percent of the resistant strains possessed the M. phenotype.
Resistance levels of S. pyogenes have decreased in Chile in the last years. Most resistant strains have M phenotype in contrast to many countries in which the MLSB constitutive phenotype is the predominant one.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial Proteins - genetics</subject><subject>Chile - epidemiology</subject><subject>Clindamycin - pharmacology</subject><subject>Drug Resistance, Bacterial - drug effects</subject><subject>Drug Resistance, Bacterial - genetics</subject><subject>Erythromycin - pharmacology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Membrane Proteins - genetics</subject><subject>Methyltransferases - genetics</subject><subject>Pharyngitis - drug therapy</subject><subject>Pharyngitis - microbiology</subject><subject>Phenotype</subject><subject>Poisson Distribution</subject><subject>Streptococcal Infections - drug therapy</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcus pyogenes</subject><subject>Streptococcus pyogenes - drug effects</subject><subject>Streptococcus pyogenes - genetics</subject><issn>0034-9887</issn><issn>0717-6163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1LxDAQhoMo7rr6FzQ3T9VJ0nz0KItfsCC4ei5pMnUj3aY2XaH_3oqrZw_DzDvvwzswhFwwuMpB6es1gMizwhjNgTEAKKYCeUDmoJnOFFPicJp_oRk5SekdgGvFzDGZcc6ZFAWfk_YZU0iDbR3SboNtHMYOE7Wtp29_KtZ0PfTYDdFF53aJdmOc3MlxTWiDsw0NKTZ2mDahpctNaJDGT-yppQyyEW1PO-xD9KfkqLZNwrN9X5DXu9uX5UO2erp_XN6sso5pPmS5dJ57FOgdB4OgPBgwzGhZKy4rLgCcEVXuha4rqTSTqtKS5yiZEdJJsSCXP7ldHz92mIZyG5LDprEtxl0qC2ZAKsXNP8h8upbr78zzPbmrtujLrg9b24_l7zPFF-8rd7w</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Rodríguez, Carlos</creator><creator>Rojas, Pablo</creator><creator>Wozniak, Aniela</creator><creator>Kalergis, Alexis M</creator><creator>Cerón, Inés</creator><creator>Riedel, Ingrid</creator><creator>Román, Juan C</creator><creator>Villarroel, Luis A</creator><creator>Berríos, Ximena</creator><creator>Bavestrello, Luis</creator><creator>García, Patricia</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>201109</creationdate><title>Resistance phenotypes and genotypes of Streptococcus pyogenes clinical isolates in Chile over a 10-year period</title><author>Rodríguez, Carlos ; Rojas, Pablo ; Wozniak, Aniela ; Kalergis, Alexis M ; Cerón, Inés ; Riedel, Ingrid ; Román, Juan C ; Villarroel, Luis A ; Berríos, Ximena ; Bavestrello, Luis ; García, Patricia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p172t-45cd2de3edc208e06d08081875f625b2300c83b4d37fb567156b7524e51835c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2011</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacterial Proteins - genetics</topic><topic>Chile - epidemiology</topic><topic>Clindamycin - pharmacology</topic><topic>Drug Resistance, Bacterial - drug effects</topic><topic>Drug Resistance, Bacterial - genetics</topic><topic>Erythromycin - pharmacology</topic><topic>Genotype</topic><topic>Humans</topic><topic>Membrane Proteins - genetics</topic><topic>Methyltransferases - genetics</topic><topic>Pharyngitis - drug therapy</topic><topic>Pharyngitis - microbiology</topic><topic>Phenotype</topic><topic>Poisson Distribution</topic><topic>Streptococcal Infections - drug therapy</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcus pyogenes</topic><topic>Streptococcus pyogenes - drug effects</topic><topic>Streptococcus pyogenes - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodríguez, Carlos</creatorcontrib><creatorcontrib>Rojas, Pablo</creatorcontrib><creatorcontrib>Wozniak, Aniela</creatorcontrib><creatorcontrib>Kalergis, Alexis M</creatorcontrib><creatorcontrib>Cerón, Inés</creatorcontrib><creatorcontrib>Riedel, Ingrid</creatorcontrib><creatorcontrib>Román, Juan C</creatorcontrib><creatorcontrib>Villarroel, Luis A</creatorcontrib><creatorcontrib>Berríos, Ximena</creatorcontrib><creatorcontrib>Bavestrello, Luis</creatorcontrib><creatorcontrib>García, Patricia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Revista medíca de Chile</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodríguez, Carlos</au><au>Rojas, Pablo</au><au>Wozniak, Aniela</au><au>Kalergis, Alexis M</au><au>Cerón, Inés</au><au>Riedel, Ingrid</au><au>Román, Juan C</au><au>Villarroel, Luis A</au><au>Berríos, Ximena</au><au>Bavestrello, Luis</au><au>García, Patricia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistance phenotypes and genotypes of Streptococcus pyogenes clinical isolates in Chile over a 10-year period</atitle><jtitle>Revista medíca de Chile</jtitle><addtitle>Rev Med Chil</addtitle><date>2011-09</date><risdate>2011</risdate><volume>139</volume><issue>9</issue><spage>1143</spage><epage>1149</epage><pages>1143-1149</pages><issn>0034-9887</issn><eissn>0717-6163</eissn><abstract>Macrolide and lincosamide resistance in Streptococcus pyogenes is due to the acquisition of mef, ermB and ermA genes, which confer different resistance phenotypes, namely M, MLSBconstitutive and MLSBinducible respectively. The last report of resistance in Chile was done in the period 1990-1998, in which resistance to macrolides was 5.4%, with M phenotype as the predominant one.
To characterize the evolution of erythromycin and clindamycin resistance and their associated genes in S. pyogenes strains isolated from patients with invasive and non-invasive infections in the period 1996 to 2005.
Resistance to erythromycin and clindamycin was determined in 1,282 clinical isolates using the disk diffusion test. Resistant isolates were analyzed by polymerase chain reaction (PCR) for the presence of the above mentioned resistance genes.
Global resistance to erythromycin and clindamycin was 3.5 and 0.7% respectively. Eighty percent of the resistant strains possessed the M. phenotype.
Resistance levels of S. pyogenes have decreased in Chile in the last years. Most resistant strains have M phenotype in contrast to many countries in which the MLSB constitutive phenotype is the predominant one.</abstract><cop>Chile</cop><pmid>22215392</pmid><doi>10.4067/S0034-98872011000900005</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics Chile - epidemiology Clindamycin - pharmacology Drug Resistance, Bacterial - drug effects Drug Resistance, Bacterial - genetics Erythromycin - pharmacology Genotype Humans Membrane Proteins - genetics Methyltransferases - genetics Pharyngitis - drug therapy Pharyngitis - microbiology Phenotype Poisson Distribution Streptococcal Infections - drug therapy Streptococcal Infections - microbiology Streptococcus pyogenes Streptococcus pyogenes - drug effects Streptococcus pyogenes - genetics |
| title | Resistance phenotypes and genotypes of Streptococcus pyogenes clinical isolates in Chile over a 10-year period |
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