Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: Characteristics of broad-spectrum protein binding and its effects on anti-tumor activity

A series of class A compounds which have the basic skeleton of ABT-737 and the h2 residues of Bim BH3 were designed, and showed broad-spectrum binding activity to target proteins similar to that of Bim BH3 peptide. Then class B compounds were synthesized by modifying the structure of the most effect...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-01, Vol.22 (1), p.39-44
Hauptverfasser:	Zheng, Can-Hui, Yang, Hui, Zhang, Meng, Lu, Shi-Hai, Shi, Duo, Wang, Juan, Chen, Xiu-Hua, Ren, Xiao-Hui, Liu, Jia, Lv, Jia-Guo, Zhu, Ju, Zhou, You-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-apoptotic Bcl-2 family proteins Anti-tumor agent anticarcinogenic activity antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Apoptosis bcl-X Protein - antagonists & inhibitors binding capacity Biological and medical sciences Biphenyl Compounds - pharmacology Broad-spectrum Cell Line, Tumor Chemistry, Pharmaceutical - methods Drug Design Drug Screening Assays, Antitumor Humans Inhibitor Medical sciences Models, Chemical Mutagenesis Myeloid Cell Leukemia Sequence 1 Protein Nitrophenols - pharmacology Pharmacology. Drug treatments Piperazines - pharmacology Protein Binding proteins Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2 - chemistry Sulfonamides - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!