Fluorescence detection of single nucleotide polymorphisms using nucleic acid probe containing tricyclic base-linked acyclonucleoside

A reliable and simple method for detecting nucleobase mutations is very important clinically because sequence variations in human DNA cause genetic diseases and genetically influenced traits. A majority of sequence variations are attributed to single nucleotide polymorphisms (SNPs). Here, we develop...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-01, Vol.22 (1), p.253-257
Hauptverfasser:	Hattori, Mayumi, Ohki, Tokimitsu, Yanase, Emiko, Ueno, Yoshihito
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclonucleoside Aryl Hydrocarbon Hydroxylases - genetics Base Pair Mismatch Biological and medical sciences color Cytochrome P-450 CYP2C9 Detection DNA DNA - genetics DNA probes fluorescence genetic disorders Genetic Techniques Genetic Variation Humans Medical sciences Models, Chemical Models, Genetic Nucleic Acid Probes - genetics Nucleic Acids Nucleosides - pharmacology Oligodeoxyribonucleotides - chemistry Pharmacology. Drug treatments Polymorphism, Single Nucleotide RNA single nucleotide polymorphism SNPs Spectrometry, Fluorescence - methods Tricyclic base
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!