Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue

High-fat diet-induced obesity is associated with a chronic state of low-grade inflammation, which pre-disposes to insulin resistance (IR), which can subsequently lead to type 2 diabetes mellitus. Macrophages represent a heterogeneous population of cells that are instrumental in initiating the innate...

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Veröffentlicht in:	Proceedings of the Nutrition Society 2011-11, Vol.70 (4), p.408-417
Hauptverfasser:	Harford, Karen A., Reynolds, Clare M., McGillicuddy, Fiona C., Roche, Helen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation adipocytes Adipose tissue Adipose Tissue - immunology Biological and medical sciences Body fat Cytokines - metabolism cytotoxicity Diabetes Diet, High-Fat - adverse effects dietary fat Dietary Fats - adverse effects Dietary Fats - immunology Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Humans Immune response immunomodulation Infiltration inflammation Inflammation - etiology Inflammation - immunology innate immunity Insulin Insulin resistance Insulin Resistance - immunology interferon-gamma interleukin-10 interleukin-1beta interleukin-6 Kinases lipids macrophages Macrophages - metabolism noninsulin-dependent diabetes mellitus Obesity Obesity - complications Obesity - immunology Proteins T-lymphocytes T-Lymphocytes - metabolism tissue repair tumor necrosis factor-alpha Vertebrates: anatomy and physiology, studies on body, several organs or systems
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