Nucleic acid probe containing fluorescent tricyclic base-linked acyclonucleoside for detection of single nucleotide polymorphisms

The development of a reliable and simple method for detecting single nucleotide polymorphisms (SNPs), common genetic variations in the human genome, is currently an important research area because SNPs are important for identifying disease-causing genes and for pharmacogenetic studies. Here, we deve...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2012-01, Vol.20 (1), p.16-24
Hauptverfasser:	Furukawa, Kinji, Hattori, Mayumi, Ohki, Tokimitsu, Kitamura, Yoshiaki, Kitade, Yukio, Ueno, Yoshihito
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclonucleoside Biological and medical sciences chemistry Detection DNA DNA - chemistry DNA - metabolism DNA probes DNA Probes - chemical synthesis DNA Probes - chemistry fluorescence Fluorescent Dyes - chemistry genes genetic variation Genome, Human Humans Imidazoles - chemical synthesis Imidazoles - chemistry Medical sciences methodology Nucleic Acid Denaturation Oligodeoxyribonucleotides - chemical synthesis Oligodeoxyribonucleotides - chemistry Pharmacology. Drug treatments Polymorphism, Single Nucleotide Pyrimidines - chemical synthesis Pyrimidines - chemistry RNA RNA - chemistry RNA - metabolism single nucleotide polymorphism SNPs Spectrometry, Fluorescence Transition Temperature Tricyclic base
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