Three-dimensional poly(1,8-octanediol–co-citrate) scaffold pore shape and permeability effects on sub-cutaneous in vivo chondrogenesis using primary chondrocytes

The objective of this study was to evaluate the coupled effects of three-dimensional poly(1,8-octanediol–co-citrate) (POC) scaffold pore shape and permeability on chondrogenesis using primary chondrocytes in vivo. Chondrogenesis was characterized as cartilage matrix formation by sulfated glycosamino...

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Veröffentlicht in:	Acta biomaterialia 2011-02, Vol.7 (2), p.505-514
Hauptverfasser:	Jeong, Claire G., Zhang, Huina, Hollister, Scott J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cartilage Cells, Cultured chondrocytes Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism chondrogenesis Chondrogenesis - drug effects Citrates - pharmacology collagen DNA - metabolism Elastic Modulus - drug effects Extracellular Matrix - drug effects Extracellular Matrix - metabolism gene expression Gene Expression Regulation - drug effects Glycosaminoglycans - metabolism Materials Testing Mechanical properties messenger RNA metalloproteinases Mice Nonlinear Dynamics Permeability Permeability - drug effects Poly(1,8-octanediol–co-citrate) scaffold Polymers - pharmacology Pore shape Porosity - drug effects Prosthesis Implantation RNA, Messenger - genetics RNA, Messenger - metabolism Stress, Mechanical Subcutaneous Tissue - drug effects Sus scrofa Tissue Scaffolds - chemistry
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