Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling

Toll-like receptor (TLR) signaling plays a critical role in innate and adaptive immune responses and must be tightly controlled. TLR4 uses LPS binding protein, MD-2, and CD14 as accessories to respond to LPS. We therefore investigated the presence of an analagous soluble cofactor that might assist i...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2011-04, Vol.34 (4), p.505-513
Hauptverfasser:	Park, Boyoun, Buti, Ludovico, Lee, Sungwook, Matsuwaki, Takashi, Spooner, Eric, Brinkmann, Melanie M., Nishihara, Masugi, Ploegh, Hidde L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Cell growth Cells, Cultured Flow cytometry Humans Intercellular Signaling Peptides and Proteins - deficiency Intercellular Signaling Peptides and Proteins - immunology Intercellular Signaling Peptides and Proteins - metabolism Mass spectrometry Mice Mice, Inbred C57BL Mice, Knockout Oligodeoxyribonucleotides - immunology Polypeptides Protein Binding Proteins Rodents Signal Transduction Studies Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - immunology Toll-Like Receptor 9 - metabolism
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