Differential expression of intermediate filaments in the process of developing hepatic steatosis

Obesity causes changes in fatty acid metabolism that consequently leads to fatty liver. To identify the possible proteins involved in the processes of obesity, we performed a proteomic analysis of obesity‐induced mouse liver. Male C57BL/6J mice that were fed a high‐fat diet (HFD) for 24 wk, develope...

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Veröffentlicht in:	Proteomics (Weinheim) 2011-07, Vol.11 (14), p.2777-2789
Hauptverfasser:	Park, Jung-Eun, Kim, Hyun Tae, Lee, Sujin, Lee, Ye-Suk, Choi, Ung-Kyu, Kang, Jeong Han, Choi, Soo Young, Kang, Tae-Cheon, Choi, Myung-Sook, Kwon, Oh-Shin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animal proteomics Animals Biological and medical sciences Body weight Cytokeratin Cytoskeleton Diet Dietary Fats Fatty acids Fatty liver Fatty Liver - metabolism Fatty Liver - physiopathology Fatty liver disease Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Profiling Hepatocytes Hepatocytes - chemistry Hepatocytes - cytology Hepatocytes - metabolism High fat diet Humans Immunohistochemistry Inflammation Intermediate filament Intermediate filaments Intermediate Filaments - metabolism Keratins - genetics Keratins - metabolism Lipid Metabolism Liver - chemistry Liver - cytology Liver - metabolism Liver - pathology Liver diseases Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Mass Spectrometry - methods Medical sciences Metabolic diseases Metabolism Mice Mice, Inbred C57BL Microarray Analysis Microfilaments Miscellaneous Obesity Obesity - physiopathology Other diseases. Semiology Proteins Proteome - analysis proteomics Proteomics - methods Random Allocation steatosis Triglycerides Two-Dimensional Difference Gel Electrophoresis - methods Vimentin Vimentin - genetics Vimentin - metabolism Western blotting
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