Effects of a novel peptide derived from human thrombomodulin on endotoxin-induced uveitis in vitro and in vivo

► We found a novel anti-inflammatory peptide (GC31) from human thrombomodulin. ► GC31 peptide suppressed the development of endotoxin induced uveitis. ► GC31 decreased leukocyte counts and protein concentration in aqueous humor. ► GC31 inhibited LPS-induced TNF-α, IL-6 and MCP-1 expression in vivo a...

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Veröffentlicht in:	FEBS letters 2011-11, Vol.585 (21), p.3457-3464
Hauptverfasser:	Jin, Huiyi, Yang, Xiaolu, Liu, Kun, Gu, Qing, Xu, Xun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Aqueous Humor - drug effects Aqueous Humor - metabolism Cell Line Chemokine CCL2 - metabolism dexamethasone DXM EIU endotoxin induced uveitis Endotoxins - toxicity Gene Expression Regulation - drug effects Humans Inflammation Interleukin-6 - genetics Lipopolysaccharide Lipopolysaccharides - pharmacology LPS Macrophages - drug effects Macrophages - metabolism Male MCP-1 Mice Molecular Sequence Data monocyte chemoattractant protein-1 NF-kappa B - metabolism NF-κB nuclear factor kappaB Peptide Peptide Fragments - chemistry Peptide Fragments - metabolism Peptide Fragments - pharmacology Peptide Fragments - therapeutic use Protein Structure, Tertiary Protein Transport - drug effects Rats, Wistar Thrombomodulin Thrombomodulin - chemistry TNF-α tumor necrosis factor α Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Uveitis Uveitis - chemically induced Uveitis - drug therapy Uveitis - metabolism Uveitis - pathology
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