Cytotoxic effects of new trans-2,4-diaryl- r-3-methyl-1,2,3,4-tetrahydroquinolines and their interaction with antitumoral drugs gemcitabine and paclitaxel on cellular lines of human breast cancer

Two tetrahydroquinoline compounds, called DM8 and DM12, from a new series of the cis-2,4-diaryl- r-3-methyl-1,2,3,4-tetrahydroquinolines, were selected for cytotoxic effects studies on cellular lines of human breast cancer. The synergistic, additive and antagonistic effects in combination of these c...

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Veröffentlicht in:	Chemico-biological interactions 2011-02, Vol.189 (3), p.215-221
Hauptverfasser:	Muñoz, Arturo, Sojo, Felipe, Arenas, Diego R. Merchan, Kouznetsov, Vladimir V., Arvelo, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant therapy antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Breast cancer breast neoplasms Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor cytotoxicity Deoxycytidine - analogs & derivatives Deoxycytidine - chemistry Deoxycytidine - pharmacology Drug Interactions Drug Screening Assays, Antitumor Drug Synergism Female growth retardation Humans paclitaxel Paclitaxel - chemistry Paclitaxel - pharmacology Quinolines - chemistry Quinolines - pharmacology Synergism Tetrahydroquinolines therapeutics
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