Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells

Microglial cells play critical roles in the immune and inflammatory responses of the central nervous system (CNS). Under pathological conditions, the activation of microglia helps in restoring CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of...

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Veröffentlicht in:	European journal of pharmacology 2010-12, Vol.648 (1), p.110-116
Hauptverfasser:	Nam, Kyong Nyon, Park, Young-Min, Jung, Hoon-Ji, Lee, Jung Yeon, Min, Byung Duk, Park, Seong-Uk, Jung, Woo-Sang, Cho, Ki-Ho, Park, Ji-Ho, Kang, Insug, Hong, Joung-Woo, Lee, Eunjoo H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - pharmacology Animals Anti-Inflammatory Agents - pharmacology Biological and medical sciences Brain - cytology Brain inflammation Carotenoids - pharmacology Crocetin Crocin Cytokines - metabolism Gardenia Interferon-gamma - pharmacology Interleukin-1β Lipopolysaccharides - pharmacology Male Medical sciences Mice Microglia Microglia - drug effects Microglia - metabolism Neurons - drug effects NF-kappa B - metabolism NF-κB Nitric oxide Nitric Oxide - biosynthesis Organotypic hippocampal slice culture Peptide Fragments - pharmacology Pharmacology. Drug treatments Rats Reactive Oxygen Species - metabolism TNF-α
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