Regulation of fas/fas ligand-mediated apoptosis by nuclear factor of activated T cells in megakaryocytes

Summary Signal transduction pathways in megakaryocytes, a rare population of bone marrow cells, are poorly understood. We have previously shown that the calcineurin‐dependent transcription factor Nuclear Factor of Activated T cells (NFAT) is expressed in megakaryocytes and is required for the transc...

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Veröffentlicht in:	British journal of haematology 2012-02, Vol.156 (4), p.523-534
Hauptverfasser:	Arabanian, Laleh S., Kujawski, Satu, Habermann, Ivonne, Ehninger, Gerhard, Kiani, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Bone marrow Calcineurin Calcineurin - metabolism calcineurin inhibitors Calcium Ionophores - pharmacology CD95 antigen Cell Line Coculture Techniques fas Fas antigen Fas Ligand Protein - metabolism fas Receptor - metabolism FasL protein Hematologic and hematopoietic diseases Humans Ionomycin - pharmacology Jurkat Cells Lymphocytes T Medical sciences Megakaryocytes Megakaryocytes - drug effects Megakaryocytes - metabolism NF-AT protein NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism peptide inhibitors Protein Transport Signal transduction Signal Transduction - drug effects T-Lymphocytes - metabolism Transcription factors Tumor necrosis factor
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