Circulating retinol-binding protein 4 and metabolic syndrome in the elderly
Summary BACKGROUND: Retinol-binding protein (RBP) 4, a human adipokine that specifically binds to retinol, has been reported to provide a link between obesity and insulin resistance. Plasma RBP4 concentration may be under the influence of age and obesity, but only a few studies has investigated this...
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| Veröffentlicht in: | Wiener medizinische Wochenschrift 2011-11, Vol.161 (21-22), p.505-510 |
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| creator | Mostafaie, Nazanin Sebesta, Christian Zehetmayer, Sonja Jungwirth, Susanne Huber, Klaus R. Hinterberger, Margareta Leitha, Thomas Hofman, Jörg Hejtman, Milos Schrattbauer, Karl Krugluger, Walter Tragl, Karl-Heinz Fischer, Peter |
| description | Summary
BACKGROUND: Retinol-binding protein (RBP) 4, a human adipokine that specifically binds to retinol, has been reported to provide a link between obesity and insulin resistance. Plasma RBP4 concentration may be under the influence of age and obesity, but only a few studies has investigated this link in elderly individuals. Consequently, we tested the correlation between RBP4 concentrations and type 2 diabetes/metabolic syndrome (MetS) components in a large population based cohort study (VITA) of elderly [1, 2]. Using a single birth cohort, this investigation could exclude the influence of age. METHODS: We evaluated the correlation of RBP4 with type 2 diabetes and MetS components including Body Mass Index (BMI), blood pressure, lipid parameters, fasting glucose insulin, homeostasis model assessment insulin resistance (HOMA-IR), and smoking in exclusively 75–76 year old participants (
N
= 232). RESULTS: In the present study, RBP4 concentrations were associated with type 2 diabetes and metabolic syndrome (MetS) components. Of all the individual components of metabolic syndrome that were associated with RBP4 concentrations, the correlations of RBP4 with serum triglycerides and a negative correlation with HDL were the strongest ones observed in our study cohort (
p |
| doi_str_mv | 10.1007/s10354-011-0885-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_917857615</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>917857615</sourcerecordid><originalsourceid>FETCH-LOGICAL-c343t-2df89174c45cc8c60964eede157d62b05b2f027906110edaacc97986b6450273</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EoqXwA1hQNiaDz7HjZEQVX6ISSwc2K7EvJVXigJ0M_fc4SmFkOp3v9aO7h5BrYHfAmLoPwFIpKAOgLM8lVSdkCTJLKZf5xylZMiZSKlMBC3IRwp4xUIXk52TBQQjOQS3J27rxZmzLoXG7xGMsfUurxtmp__L9gI1LRFI6m3Q4lFXfNiYJB2d932ESZ8MnJtha9O3hkpzVZRvw6lhXZPv0uF2_0M378-v6YUNNKtKBclvnBShhhDQmNxkrMoFoEaSyGa-YrHjNuCpYBsDQlqUxhSryrMqEjO_pitzO2Lje94hh0F0TDLZt6bAfg47sXKoMZEzCnDS-D8Fjrb9805X-oIHpyaCeDepoUE8G9US_OdLHqkP79-NXWQzwORDiyO3Q630_ehcP_of6A8oteyw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>917857615</pqid></control><display><type>article</type><title>Circulating retinol-binding protein 4 and metabolic syndrome in the elderly</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Mostafaie, Nazanin ; Sebesta, Christian ; Zehetmayer, Sonja ; Jungwirth, Susanne ; Huber, Klaus R. ; Hinterberger, Margareta ; Leitha, Thomas ; Hofman, Jörg ; Hejtman, Milos ; Schrattbauer, Karl ; Krugluger, Walter ; Tragl, Karl-Heinz ; Fischer, Peter</creator><creatorcontrib>Mostafaie, Nazanin ; Sebesta, Christian ; Zehetmayer, Sonja ; Jungwirth, Susanne ; Huber, Klaus R. ; Hinterberger, Margareta ; Leitha, Thomas ; Hofman, Jörg ; Hejtman, Milos ; Schrattbauer, Karl ; Krugluger, Walter ; Tragl, Karl-Heinz ; Fischer, Peter</creatorcontrib><description>Summary
BACKGROUND: Retinol-binding protein (RBP) 4, a human adipokine that specifically binds to retinol, has been reported to provide a link between obesity and insulin resistance. Plasma RBP4 concentration may be under the influence of age and obesity, but only a few studies has investigated this link in elderly individuals. Consequently, we tested the correlation between RBP4 concentrations and type 2 diabetes/metabolic syndrome (MetS) components in a large population based cohort study (VITA) of elderly [1, 2]. Using a single birth cohort, this investigation could exclude the influence of age. METHODS: We evaluated the correlation of RBP4 with type 2 diabetes and MetS components including Body Mass Index (BMI), blood pressure, lipid parameters, fasting glucose insulin, homeostasis model assessment insulin resistance (HOMA-IR), and smoking in exclusively 75–76 year old participants (
N
= 232). RESULTS: In the present study, RBP4 concentrations were associated with type 2 diabetes and metabolic syndrome (MetS) components. Of all the individual components of metabolic syndrome that were associated with RBP4 concentrations, the correlations of RBP4 with serum triglycerides and a negative correlation with HDL were the strongest ones observed in our study cohort (
p
<0.0001). CONCLUSIONS: RBP4 plays a role in biological mechanisms that are responsible for insulin resistance and development of type 2 diabetes.</description><identifier>ISSN: 0043-5341</identifier><identifier>EISSN: 1563-258X</identifier><identifier>DOI: 10.1007/s10354-011-0885-7</identifier><identifier>PMID: 21442217</identifier><language>eng</language><publisher>Vienna: Springer-Verlag</publisher><subject>Age Factors ; Aged ; Austria ; Blood Glucose - analysis ; Blood Pressure - physiology ; Body Mass Index ; Cholesterol, HDL - blood ; Cohort Studies ; Diabetes Mellitus, Type 2 - blood ; Family Medicine ; Female ; General Practice ; Geriatrics/Gerontology ; Humans ; Infectious Diseases ; Insulin Resistance - physiology ; Internal Medicine ; Main Topic ; Male ; Medicine ; Medicine & Public Health ; Metabolic Syndrome - blood ; Obesity - blood ; Pharmacology/Toxicology ; Reference Values ; Retinol-Binding Proteins, Plasma - analysis ; Statistics as Topic ; Triglycerides - blood</subject><ispartof>Wiener medizinische Wochenschrift, 2011-11, Vol.161 (21-22), p.505-510</ispartof><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-2df89174c45cc8c60964eede157d62b05b2f027906110edaacc97986b6450273</citedby><cites>FETCH-LOGICAL-c343t-2df89174c45cc8c60964eede157d62b05b2f027906110edaacc97986b6450273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10354-011-0885-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10354-011-0885-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21442217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mostafaie, Nazanin</creatorcontrib><creatorcontrib>Sebesta, Christian</creatorcontrib><creatorcontrib>Zehetmayer, Sonja</creatorcontrib><creatorcontrib>Jungwirth, Susanne</creatorcontrib><creatorcontrib>Huber, Klaus R.</creatorcontrib><creatorcontrib>Hinterberger, Margareta</creatorcontrib><creatorcontrib>Leitha, Thomas</creatorcontrib><creatorcontrib>Hofman, Jörg</creatorcontrib><creatorcontrib>Hejtman, Milos</creatorcontrib><creatorcontrib>Schrattbauer, Karl</creatorcontrib><creatorcontrib>Krugluger, Walter</creatorcontrib><creatorcontrib>Tragl, Karl-Heinz</creatorcontrib><creatorcontrib>Fischer, Peter</creatorcontrib><title>Circulating retinol-binding protein 4 and metabolic syndrome in the elderly</title><title>Wiener medizinische Wochenschrift</title><addtitle>Wien Med Wochenschr</addtitle><addtitle>Wien Med Wochenschr</addtitle><description>Summary
BACKGROUND: Retinol-binding protein (RBP) 4, a human adipokine that specifically binds to retinol, has been reported to provide a link between obesity and insulin resistance. Plasma RBP4 concentration may be under the influence of age and obesity, but only a few studies has investigated this link in elderly individuals. Consequently, we tested the correlation between RBP4 concentrations and type 2 diabetes/metabolic syndrome (MetS) components in a large population based cohort study (VITA) of elderly [1, 2]. Using a single birth cohort, this investigation could exclude the influence of age. METHODS: We evaluated the correlation of RBP4 with type 2 diabetes and MetS components including Body Mass Index (BMI), blood pressure, lipid parameters, fasting glucose insulin, homeostasis model assessment insulin resistance (HOMA-IR), and smoking in exclusively 75–76 year old participants (
N
= 232). RESULTS: In the present study, RBP4 concentrations were associated with type 2 diabetes and metabolic syndrome (MetS) components. Of all the individual components of metabolic syndrome that were associated with RBP4 concentrations, the correlations of RBP4 with serum triglycerides and a negative correlation with HDL were the strongest ones observed in our study cohort (
p
<0.0001). CONCLUSIONS: RBP4 plays a role in biological mechanisms that are responsible for insulin resistance and development of type 2 diabetes.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Austria</subject><subject>Blood Glucose - analysis</subject><subject>Blood Pressure - physiology</subject><subject>Body Mass Index</subject><subject>Cholesterol, HDL - blood</subject><subject>Cohort Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Family Medicine</subject><subject>Female</subject><subject>General Practice</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Insulin Resistance - physiology</subject><subject>Internal Medicine</subject><subject>Main Topic</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Syndrome - blood</subject><subject>Obesity - blood</subject><subject>Pharmacology/Toxicology</subject><subject>Reference Values</subject><subject>Retinol-Binding Proteins, Plasma - analysis</subject><subject>Statistics as Topic</subject><subject>Triglycerides - blood</subject><issn>0043-5341</issn><issn>1563-258X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwA1hQNiaDz7HjZEQVX6ISSwc2K7EvJVXigJ0M_fc4SmFkOp3v9aO7h5BrYHfAmLoPwFIpKAOgLM8lVSdkCTJLKZf5xylZMiZSKlMBC3IRwp4xUIXk52TBQQjOQS3J27rxZmzLoXG7xGMsfUurxtmp__L9gI1LRFI6m3Q4lFXfNiYJB2d932ESZ8MnJtha9O3hkpzVZRvw6lhXZPv0uF2_0M378-v6YUNNKtKBclvnBShhhDQmNxkrMoFoEaSyGa-YrHjNuCpYBsDQlqUxhSryrMqEjO_pitzO2Lje94hh0F0TDLZt6bAfg47sXKoMZEzCnDS-D8Fjrb9805X-oIHpyaCeDepoUE8G9US_OdLHqkP79-NXWQzwORDiyO3Q630_ehcP_of6A8oteyw</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Mostafaie, Nazanin</creator><creator>Sebesta, Christian</creator><creator>Zehetmayer, Sonja</creator><creator>Jungwirth, Susanne</creator><creator>Huber, Klaus R.</creator><creator>Hinterberger, Margareta</creator><creator>Leitha, Thomas</creator><creator>Hofman, Jörg</creator><creator>Hejtman, Milos</creator><creator>Schrattbauer, Karl</creator><creator>Krugluger, Walter</creator><creator>Tragl, Karl-Heinz</creator><creator>Fischer, Peter</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Circulating retinol-binding protein 4 and metabolic syndrome in the elderly</title><author>Mostafaie, Nazanin ; Sebesta, Christian ; Zehetmayer, Sonja ; Jungwirth, Susanne ; Huber, Klaus R. ; Hinterberger, Margareta ; Leitha, Thomas ; Hofman, Jörg ; Hejtman, Milos ; Schrattbauer, Karl ; Krugluger, Walter ; Tragl, Karl-Heinz ; Fischer, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-2df89174c45cc8c60964eede157d62b05b2f027906110edaacc97986b6450273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Austria</topic><topic>Blood Glucose - analysis</topic><topic>Blood Pressure - physiology</topic><topic>Body Mass Index</topic><topic>Cholesterol, HDL - blood</topic><topic>Cohort Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Family Medicine</topic><topic>Female</topic><topic>General Practice</topic><topic>Geriatrics/Gerontology</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Insulin Resistance - physiology</topic><topic>Internal Medicine</topic><topic>Main Topic</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Syndrome - blood</topic><topic>Obesity - blood</topic><topic>Pharmacology/Toxicology</topic><topic>Reference Values</topic><topic>Retinol-Binding Proteins, Plasma - analysis</topic><topic>Statistics as Topic</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mostafaie, Nazanin</creatorcontrib><creatorcontrib>Sebesta, Christian</creatorcontrib><creatorcontrib>Zehetmayer, Sonja</creatorcontrib><creatorcontrib>Jungwirth, Susanne</creatorcontrib><creatorcontrib>Huber, Klaus R.</creatorcontrib><creatorcontrib>Hinterberger, Margareta</creatorcontrib><creatorcontrib>Leitha, Thomas</creatorcontrib><creatorcontrib>Hofman, Jörg</creatorcontrib><creatorcontrib>Hejtman, Milos</creatorcontrib><creatorcontrib>Schrattbauer, Karl</creatorcontrib><creatorcontrib>Krugluger, Walter</creatorcontrib><creatorcontrib>Tragl, Karl-Heinz</creatorcontrib><creatorcontrib>Fischer, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Wiener medizinische Wochenschrift</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mostafaie, Nazanin</au><au>Sebesta, Christian</au><au>Zehetmayer, Sonja</au><au>Jungwirth, Susanne</au><au>Huber, Klaus R.</au><au>Hinterberger, Margareta</au><au>Leitha, Thomas</au><au>Hofman, Jörg</au><au>Hejtman, Milos</au><au>Schrattbauer, Karl</au><au>Krugluger, Walter</au><au>Tragl, Karl-Heinz</au><au>Fischer, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating retinol-binding protein 4 and metabolic syndrome in the elderly</atitle><jtitle>Wiener medizinische Wochenschrift</jtitle><stitle>Wien Med Wochenschr</stitle><addtitle>Wien Med Wochenschr</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>161</volume><issue>21-22</issue><spage>505</spage><epage>510</epage><pages>505-510</pages><issn>0043-5341</issn><eissn>1563-258X</eissn><abstract>Summary
BACKGROUND: Retinol-binding protein (RBP) 4, a human adipokine that specifically binds to retinol, has been reported to provide a link between obesity and insulin resistance. Plasma RBP4 concentration may be under the influence of age and obesity, but only a few studies has investigated this link in elderly individuals. Consequently, we tested the correlation between RBP4 concentrations and type 2 diabetes/metabolic syndrome (MetS) components in a large population based cohort study (VITA) of elderly [1, 2]. Using a single birth cohort, this investigation could exclude the influence of age. METHODS: We evaluated the correlation of RBP4 with type 2 diabetes and MetS components including Body Mass Index (BMI), blood pressure, lipid parameters, fasting glucose insulin, homeostasis model assessment insulin resistance (HOMA-IR), and smoking in exclusively 75–76 year old participants (
N
= 232). RESULTS: In the present study, RBP4 concentrations were associated with type 2 diabetes and metabolic syndrome (MetS) components. Of all the individual components of metabolic syndrome that were associated with RBP4 concentrations, the correlations of RBP4 with serum triglycerides and a negative correlation with HDL were the strongest ones observed in our study cohort (
p
<0.0001). CONCLUSIONS: RBP4 plays a role in biological mechanisms that are responsible for insulin resistance and development of type 2 diabetes.</abstract><cop>Vienna</cop><pub>Springer-Verlag</pub><pmid>21442217</pmid><doi>10.1007/s10354-011-0885-7</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0043-5341 |
| ispartof | Wiener medizinische Wochenschrift, 2011-11, Vol.161 (21-22), p.505-510 |
| issn | 0043-5341 1563-258X |
| language | eng |
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| subjects | Age Factors Aged Austria Blood Glucose - analysis Blood Pressure - physiology Body Mass Index Cholesterol, HDL - blood Cohort Studies Diabetes Mellitus, Type 2 - blood Family Medicine Female General Practice Geriatrics/Gerontology Humans Infectious Diseases Insulin Resistance - physiology Internal Medicine Main Topic Male Medicine Medicine & Public Health Metabolic Syndrome - blood Obesity - blood Pharmacology/Toxicology Reference Values Retinol-Binding Proteins, Plasma - analysis Statistics as Topic Triglycerides - blood |
| title | Circulating retinol-binding protein 4 and metabolic syndrome in the elderly |
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