Antibody Adsorption and Orientation on Hydrophobic Surfaces

The orientation of a monoclonal, anti-streptavidin human IgG1 antibody on a model hydrophobic, CH3-terminated surface (1-dodecanethiol self-assembled monolayer on gold) was studied by monitoring the mechanical coupling between the adsorbed layer and the surface as well as the binding of molecular pr...

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Veröffentlicht in:	Langmuir 2012-01, Vol.28 (3), p.1765-1774
Hauptverfasser:	Wiseman, Meredith E, Frank, Curtis W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Antibodies, Monoclonal - chemistry Bacterial Proteins - chemistry Bacterial Proteins - immunology Chemistry Exact sciences and technology General and physical chemistry Gold Hydrophobic and Hydrophilic Interactions Immunoglobulin Fab Fragments - chemistry Immunoglobulin G - chemistry Protein Binding Quartz Crystal Microbalance Techniques Receptors, Fc - chemistry Receptors, Fc - immunology Serum Albumin, Bovine - chemistry Streptavidin - chemistry Streptavidin - immunology Sulfhydryl Compounds - chemistry Surface physical chemistry Surface Properties
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