The presumed atypical chemokine receptor CXCR7 signals through G(i/o) proteins in primary rodent astrocytes and human glioma cells

SDF-1/CXCL12 binds to the chemokine receptors, CXCR4 and CXCR7, and controls cell proliferation and migration during development, tumorigenesis, and inflammatory processes. It is currently assumed that CXCR7 would represent an atypical or scavenger chemokine receptor which modulates the function of...

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Veröffentlicht in:	Glia 2012-03, Vol.60 (3), p.372-381
Hauptverfasser:	Odemis, Veysel, Lipfert, Jana, Kraft, Robert, Hajek, Peter, Abraham, Getu, Hattermann, Kirsten, Mentlein, Rolf, Engele, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Arrestins - metabolism Astrocytoma - pathology beta-Arrestins Calcium - metabolism Cell Proliferation Cells, Cultured Cerebral Cortex - cytology Chemokine CXCL12 - metabolism Chemotaxis - drug effects Chemotaxis - genetics Embryo, Mammalian Enzyme Inhibitors - pharmacology GTP-Binding Protein alpha Subunits, Gi-Go - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - pharmacokinetics Humans Mice Mice, Knockout Neuroglia - drug effects Neuroglia - metabolism Rats Rats, Sprague-Dawley Receptors, CXCR - genetics Receptors, CXCR - metabolism Receptors, CXCR4 - deficiency RNA Interference - physiology Signal Transduction - drug effects Signal Transduction - physiology Sulfur Isotopes - pharmacokinetics
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