The Impact of 18F-Fluorodeoxyglucose Positron Emission Tomography Positive Lymph Nodes on Postoperative Recurrence and Survival in Resectable Thoracic Esophageal Squamous Cell Carcinoma
Background Induction therapy is not always beneficial for all patients. Therefore, it is important to identify the patients with a high rate of recurrence. The occurrence of lymph node metastases (LNMs) strongly influences the postoperative survival in patients with esophageal cancer. We investigate...
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| Veröffentlicht in: | Annals of surgical oncology 2012-02, Vol.19 (2), p.652-660 |
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| creator | Yasuda, Takushi Higuchi, Ichiro Yano, Masahiko Miyata, Hiroshi Yamasaki, Makoto Takiguchi, Shuji Fujiwara, Yoshiyuki Hatazawa, Jun Doki, Yuichiro |
| description | Background
Induction therapy is not always beneficial for all patients. Therefore, it is important to identify the patients with a high rate of recurrence. The occurrence of lymph node metastases (LNMs) strongly influences the postoperative survival in patients with esophageal cancer. We investigated the usefulness of an LN evaluation by initial
18
F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in prediction of postoperative recurrence for patients with resectable esophageal squamous cell carcinoma (ESCC).
Methods
A total of 76 ESCC patients who did not undergo induction therapy, but who did receive a curative resection were divided into PET-node (PET-N) positive (
n
= 26) and negative (
n
= 50) groups according to the presence or absence of FDG uptake in LNs. The PET-N status was compared with the size and the number of LNMs, as well as with the survival and failure patterns.
Results
PET positive LNs involved a significantly larger size of metastatic nests than PET negative LNs (
P
= 0.002). The PET-N negative group showed a higher proportion of patients with 2 or fewer LNMs (92.0%), a higher 5-year relapse-free survival (75.1%) and a higher overall survival (70.0%), and a lower postoperative recurrence (24.0%) than the 15.4, 29.6, 30.3, and 69.2% values in the PET-N positive group, respectively, (
P
|
| doi_str_mv | 10.1245/s10434-011-1928-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_917855636</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>917855636</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2544-1b3e7c167ed59aea91baf53178d186bcf7d7833f178c64a7ded413e4c11986193</originalsourceid><addsrcrecordid>eNp9Uc1u1DAQthCIlsIDcEG-cQpkEsdJjmi1C5VWBdHlbDnOZOMqiVM7XnUfjbdj2hSOnDz6_jTjj7H3kH6CTBSfA6QiF0kKkECdVYl4wS6hIETICl7SnMoqqTNZXLA3IdylKZR5WrxmFxmUshZSXrLfhx759Thrs3DXcah2yW6IzrsW3cP5OETjAvIfLtjFu4lvRxuCpeHgRnf0eu7PK2lPyPfnce75DVkDJwnhi5vR6yfyJ5roPU4GuZ5afhv9yZ70wO1EVECz6GZAfuid18Yavg1u7vURSXF7H_XoYuAbHAa-0d7YyY36LXvV6SHgu-f3iv3abQ-bb8n--9frzZd9YrJCiASaHEsDssS2qDXqGhrdFTmUVQuVbExXtmWV5x0BRgpdttgKyFEYgLqSUOdX7OOaO3t3HzEsiv7A0Cp6QtpK1eQsCplLUsKqNN6F4LFTs7ej9mcFqXosTK2FKSpMPRamBHk-PKfHZsT2n-NvQyTIVkEgajqiV3cu-oku_k_qH_SepN4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>917855636</pqid></control><display><type>article</type><title>The Impact of 18F-Fluorodeoxyglucose Positron Emission Tomography Positive Lymph Nodes on Postoperative Recurrence and Survival in Resectable Thoracic Esophageal Squamous Cell Carcinoma</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Yasuda, Takushi ; Higuchi, Ichiro ; Yano, Masahiko ; Miyata, Hiroshi ; Yamasaki, Makoto ; Takiguchi, Shuji ; Fujiwara, Yoshiyuki ; Hatazawa, Jun ; Doki, Yuichiro</creator><creatorcontrib>Yasuda, Takushi ; Higuchi, Ichiro ; Yano, Masahiko ; Miyata, Hiroshi ; Yamasaki, Makoto ; Takiguchi, Shuji ; Fujiwara, Yoshiyuki ; Hatazawa, Jun ; Doki, Yuichiro</creatorcontrib><description>Background
Induction therapy is not always beneficial for all patients. Therefore, it is important to identify the patients with a high rate of recurrence. The occurrence of lymph node metastases (LNMs) strongly influences the postoperative survival in patients with esophageal cancer. We investigated the usefulness of an LN evaluation by initial
18
F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in prediction of postoperative recurrence for patients with resectable esophageal squamous cell carcinoma (ESCC).
Methods
A total of 76 ESCC patients who did not undergo induction therapy, but who did receive a curative resection were divided into PET-node (PET-N) positive (
n
= 26) and negative (
n
= 50) groups according to the presence or absence of FDG uptake in LNs. The PET-N status was compared with the size and the number of LNMs, as well as with the survival and failure patterns.
Results
PET positive LNs involved a significantly larger size of metastatic nests than PET negative LNs (
P
= 0.002). The PET-N negative group showed a higher proportion of patients with 2 or fewer LNMs (92.0%), a higher 5-year relapse-free survival (75.1%) and a higher overall survival (70.0%), and a lower postoperative recurrence (24.0%) than the 15.4, 29.6, 30.3, and 69.2% values in the PET-N positive group, respectively, (
P
< 0.005). Multivariate analyses identified the PET-N status to be the most significant preoperative risk factor for postoperative recurrence (
P
= 0.031).
Conclusion
The preoperative PET-N status in patients with resectable ESCC was significantly associated with the size and the number of LNMs and was therefore found to reliably identify the high-risk population for postoperative recurrence.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-011-1928-4</identifier><identifier>PMID: 21769466</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell - diagnostic imaging ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - surgery ; Esophageal Neoplasms - diagnostic imaging ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - surgery ; Female ; Fluorodeoxyglucose F18 ; Follow-Up Studies ; Humans ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic Metastasis ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Grading ; Neoplasm Recurrence, Local - diagnostic imaging ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - surgery ; Neoplasm Staging ; Oncology ; Positron-Emission Tomography ; Postoperative Period ; Prognosis ; Radiopharmaceuticals ; Retrospective Studies ; Sensitivity and Specificity ; Surgery ; Surgical Oncology ; Survival Rate ; Thoracic Neoplasms - diagnostic imaging ; Thoracic Neoplasms - mortality ; Thoracic Neoplasms - surgery ; Thoracic Oncology</subject><ispartof>Annals of surgical oncology, 2012-02, Vol.19 (2), p.652-660</ispartof><rights>Society of Surgical Oncology 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2544-1b3e7c167ed59aea91baf53178d186bcf7d7833f178c64a7ded413e4c11986193</citedby><cites>FETCH-LOGICAL-c2544-1b3e7c167ed59aea91baf53178d186bcf7d7833f178c64a7ded413e4c11986193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-011-1928-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-011-1928-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21769466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yasuda, Takushi</creatorcontrib><creatorcontrib>Higuchi, Ichiro</creatorcontrib><creatorcontrib>Yano, Masahiko</creatorcontrib><creatorcontrib>Miyata, Hiroshi</creatorcontrib><creatorcontrib>Yamasaki, Makoto</creatorcontrib><creatorcontrib>Takiguchi, Shuji</creatorcontrib><creatorcontrib>Fujiwara, Yoshiyuki</creatorcontrib><creatorcontrib>Hatazawa, Jun</creatorcontrib><creatorcontrib>Doki, Yuichiro</creatorcontrib><title>The Impact of 18F-Fluorodeoxyglucose Positron Emission Tomography Positive Lymph Nodes on Postoperative Recurrence and Survival in Resectable Thoracic Esophageal Squamous Cell Carcinoma</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Induction therapy is not always beneficial for all patients. Therefore, it is important to identify the patients with a high rate of recurrence. The occurrence of lymph node metastases (LNMs) strongly influences the postoperative survival in patients with esophageal cancer. We investigated the usefulness of an LN evaluation by initial
18
F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in prediction of postoperative recurrence for patients with resectable esophageal squamous cell carcinoma (ESCC).
Methods
A total of 76 ESCC patients who did not undergo induction therapy, but who did receive a curative resection were divided into PET-node (PET-N) positive (
n
= 26) and negative (
n
= 50) groups according to the presence or absence of FDG uptake in LNs. The PET-N status was compared with the size and the number of LNMs, as well as with the survival and failure patterns.
Results
PET positive LNs involved a significantly larger size of metastatic nests than PET negative LNs (
P
= 0.002). The PET-N negative group showed a higher proportion of patients with 2 or fewer LNMs (92.0%), a higher 5-year relapse-free survival (75.1%) and a higher overall survival (70.0%), and a lower postoperative recurrence (24.0%) than the 15.4, 29.6, 30.3, and 69.2% values in the PET-N positive group, respectively, (
P
< 0.005). Multivariate analyses identified the PET-N status to be the most significant preoperative risk factor for postoperative recurrence (
P
= 0.031).
Conclusion
The preoperative PET-N status in patients with resectable ESCC was significantly associated with the size and the number of LNMs and was therefore found to reliably identify the high-risk population for postoperative recurrence.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Squamous Cell - diagnostic imaging</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Esophageal Neoplasms - diagnostic imaging</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Recurrence, Local - diagnostic imaging</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Positron-Emission Tomography</subject><subject>Postoperative Period</subject><subject>Prognosis</subject><subject>Radiopharmaceuticals</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Thoracic Neoplasms - diagnostic imaging</subject><subject>Thoracic Neoplasms - mortality</subject><subject>Thoracic Neoplasms - surgery</subject><subject>Thoracic Oncology</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uc1u1DAQthCIlsIDcEG-cQpkEsdJjmi1C5VWBdHlbDnOZOMqiVM7XnUfjbdj2hSOnDz6_jTjj7H3kH6CTBSfA6QiF0kKkECdVYl4wS6hIETICl7SnMoqqTNZXLA3IdylKZR5WrxmFxmUshZSXrLfhx759Thrs3DXcah2yW6IzrsW3cP5OETjAvIfLtjFu4lvRxuCpeHgRnf0eu7PK2lPyPfnce75DVkDJwnhi5vR6yfyJ5roPU4GuZ5afhv9yZ70wO1EVECz6GZAfuid18Yavg1u7vURSXF7H_XoYuAbHAa-0d7YyY36LXvV6SHgu-f3iv3abQ-bb8n--9frzZd9YrJCiASaHEsDssS2qDXqGhrdFTmUVQuVbExXtmWV5x0BRgpdttgKyFEYgLqSUOdX7OOaO3t3HzEsiv7A0Cp6QtpK1eQsCplLUsKqNN6F4LFTs7ej9mcFqXosTK2FKSpMPRamBHk-PKfHZsT2n-NvQyTIVkEgajqiV3cu-oku_k_qH_SepN4</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>Yasuda, Takushi</creator><creator>Higuchi, Ichiro</creator><creator>Yano, Masahiko</creator><creator>Miyata, Hiroshi</creator><creator>Yamasaki, Makoto</creator><creator>Takiguchi, Shuji</creator><creator>Fujiwara, Yoshiyuki</creator><creator>Hatazawa, Jun</creator><creator>Doki, Yuichiro</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201202</creationdate><title>The Impact of 18F-Fluorodeoxyglucose Positron Emission Tomography Positive Lymph Nodes on Postoperative Recurrence and Survival in Resectable Thoracic Esophageal Squamous Cell Carcinoma</title><author>Yasuda, Takushi ; Higuchi, Ichiro ; Yano, Masahiko ; Miyata, Hiroshi ; Yamasaki, Makoto ; Takiguchi, Shuji ; Fujiwara, Yoshiyuki ; Hatazawa, Jun ; Doki, Yuichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2544-1b3e7c167ed59aea91baf53178d186bcf7d7833f178c64a7ded413e4c11986193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Squamous Cell - diagnostic imaging</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Esophageal Neoplasms - diagnostic imaging</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Recurrence, Local - diagnostic imaging</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Positron-Emission Tomography</topic><topic>Postoperative Period</topic><topic>Prognosis</topic><topic>Radiopharmaceuticals</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Thoracic Neoplasms - diagnostic imaging</topic><topic>Thoracic Neoplasms - mortality</topic><topic>Thoracic Neoplasms - surgery</topic><topic>Thoracic Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yasuda, Takushi</creatorcontrib><creatorcontrib>Higuchi, Ichiro</creatorcontrib><creatorcontrib>Yano, Masahiko</creatorcontrib><creatorcontrib>Miyata, Hiroshi</creatorcontrib><creatorcontrib>Yamasaki, Makoto</creatorcontrib><creatorcontrib>Takiguchi, Shuji</creatorcontrib><creatorcontrib>Fujiwara, Yoshiyuki</creatorcontrib><creatorcontrib>Hatazawa, Jun</creatorcontrib><creatorcontrib>Doki, Yuichiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yasuda, Takushi</au><au>Higuchi, Ichiro</au><au>Yano, Masahiko</au><au>Miyata, Hiroshi</au><au>Yamasaki, Makoto</au><au>Takiguchi, Shuji</au><au>Fujiwara, Yoshiyuki</au><au>Hatazawa, Jun</au><au>Doki, Yuichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of 18F-Fluorodeoxyglucose Positron Emission Tomography Positive Lymph Nodes on Postoperative Recurrence and Survival in Resectable Thoracic Esophageal Squamous Cell Carcinoma</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2012-02</date><risdate>2012</risdate><volume>19</volume><issue>2</issue><spage>652</spage><epage>660</epage><pages>652-660</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Induction therapy is not always beneficial for all patients. Therefore, it is important to identify the patients with a high rate of recurrence. The occurrence of lymph node metastases (LNMs) strongly influences the postoperative survival in patients with esophageal cancer. We investigated the usefulness of an LN evaluation by initial
18
F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in prediction of postoperative recurrence for patients with resectable esophageal squamous cell carcinoma (ESCC).
Methods
A total of 76 ESCC patients who did not undergo induction therapy, but who did receive a curative resection were divided into PET-node (PET-N) positive (
n
= 26) and negative (
n
= 50) groups according to the presence or absence of FDG uptake in LNs. The PET-N status was compared with the size and the number of LNMs, as well as with the survival and failure patterns.
Results
PET positive LNs involved a significantly larger size of metastatic nests than PET negative LNs (
P
= 0.002). The PET-N negative group showed a higher proportion of patients with 2 or fewer LNMs (92.0%), a higher 5-year relapse-free survival (75.1%) and a higher overall survival (70.0%), and a lower postoperative recurrence (24.0%) than the 15.4, 29.6, 30.3, and 69.2% values in the PET-N positive group, respectively, (
P
< 0.005). Multivariate analyses identified the PET-N status to be the most significant preoperative risk factor for postoperative recurrence (
P
= 0.031).
Conclusion
The preoperative PET-N status in patients with resectable ESCC was significantly associated with the size and the number of LNMs and was therefore found to reliably identify the high-risk population for postoperative recurrence.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>21769466</pmid><doi>10.1245/s10434-011-1928-4</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2012-02, Vol.19 (2), p.652-660 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| subjects | Aged Aged, 80 and over Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - surgery Esophageal Neoplasms - diagnostic imaging Esophageal Neoplasms - mortality Esophageal Neoplasms - surgery Female Fluorodeoxyglucose F18 Follow-Up Studies Humans Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis Male Medicine Medicine & Public Health Middle Aged Neoplasm Grading Neoplasm Recurrence, Local - diagnostic imaging Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - surgery Neoplasm Staging Oncology Positron-Emission Tomography Postoperative Period Prognosis Radiopharmaceuticals Retrospective Studies Sensitivity and Specificity Surgery Surgical Oncology Survival Rate Thoracic Neoplasms - diagnostic imaging Thoracic Neoplasms - mortality Thoracic Neoplasms - surgery Thoracic Oncology |
| title | The Impact of 18F-Fluorodeoxyglucose Positron Emission Tomography Positive Lymph Nodes on Postoperative Recurrence and Survival in Resectable Thoracic Esophageal Squamous Cell Carcinoma |
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