Dentine as a bioactive extracellular matrix
Abstract As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Neverthel...
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| Veröffentlicht in: | Archives of oral biology 2012-02, Vol.57 (2), p.109-121 |
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| container_title | Archives of oral biology |
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| creator | Smith, A.J Scheven, B.A Takahashi, Y Ferracane, J.L Shelton, R.M Cooper, P.R |
| description | Abstract As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Nevertheless, dentine–pulp demonstrates strong regenerative potential which allows it to respond to disease and traumatic injury. Such responses are strongly influenced by cell–matrix interactions and modified by disease processes, including infection and inflammation. The identification of many bioactive molecules bound within dentine matrix has allowed their potential involvement in regenerative and other tissue responses to be better understood and new opportunities to be recognised for novel clinical therapies. |
| doi_str_mv | 10.1016/j.archoralbio.2011.07.008 |
| format | Article |
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Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Nevertheless, dentine–pulp demonstrates strong regenerative potential which allows it to respond to disease and traumatic injury. Such responses are strongly influenced by cell–matrix interactions and modified by disease processes, including infection and inflammation. The identification of many bioactive molecules bound within dentine matrix has allowed their potential involvement in regenerative and other tissue responses to be better understood and new opportunities to be recognised for novel clinical therapies.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2011.07.008</identifier><identifier>PMID: 21855856</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Bioactive ; Cell Communication ; Cytokines - physiology ; Dental Pulp - physiology ; Dentin - physiology ; Dentine ; Dentistry ; Extracellular matrix ; Extracellular Matrix - physiology ; Humans ; Inflammation ; Intercellular Signaling Peptides and Proteins - physiology ; Neuropeptides - physiology ; Odontoblasts - physiology ; Regeneration</subject><ispartof>Archives of oral biology, 2012-02, Vol.57 (2), p.109-121</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-8169af7d27ba771c6ee7464d8709739dfd079da54e66b9bd445393ac2ca3df0b3</citedby><cites>FETCH-LOGICAL-c431t-8169af7d27ba771c6ee7464d8709739dfd079da54e66b9bd445393ac2ca3df0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0003996911002470$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21855856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, A.J</creatorcontrib><creatorcontrib>Scheven, B.A</creatorcontrib><creatorcontrib>Takahashi, Y</creatorcontrib><creatorcontrib>Ferracane, J.L</creatorcontrib><creatorcontrib>Shelton, R.M</creatorcontrib><creatorcontrib>Cooper, P.R</creatorcontrib><title>Dentine as a bioactive extracellular matrix</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>Abstract As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Nevertheless, dentine–pulp demonstrates strong regenerative potential which allows it to respond to disease and traumatic injury. Such responses are strongly influenced by cell–matrix interactions and modified by disease processes, including infection and inflammation. The identification of many bioactive molecules bound within dentine matrix has allowed their potential involvement in regenerative and other tissue responses to be better understood and new opportunities to be recognised for novel clinical therapies.</description><subject>Advanced Basic Science</subject><subject>Bioactive</subject><subject>Cell Communication</subject><subject>Cytokines - physiology</subject><subject>Dental Pulp - physiology</subject><subject>Dentin - physiology</subject><subject>Dentine</subject><subject>Dentistry</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - physiology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Intercellular Signaling Peptides and Proteins - physiology</subject><subject>Neuropeptides - physiology</subject><subject>Odontoblasts - physiology</subject><subject>Regeneration</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtP3UAMhUeoFVwefwGFVRdVUjuPmcwGqboUqITURWE9cmYcMbe5CcwkCP59E12KUFesLEvnHNufhThDyBBQfttkFOz9EKhr_JDlgJiBygDqPbHCWukUK5CfxAoAilRrqQ_EYYybua2kxH1xkGNdVXUlV-LrBfej7zmhmFAyx5Ed_RMn_DwGstx1U0ch2dIY_POx-NxSF_nktR6Ju8sft-vr9ObX1c_195vUlgWOaY1SU6tcrhpSCq1kVqUsXa1Aq0K71oHSjqqSpWx048qyKnRBNrdUuBaa4kh82eU-hOFx4jiarY_LLtTzMEWjUdVVqWqYlXqntGGIMXBrHoLfUngxCGZBZTbmHSqzoDKgzIxq9p6-TpmaLbs35z82s2C9E_B865PnYKL13Ft2PrAdjRv8h8ac_5diO997S90ffuG4GabQzzANmpgbML-Xny0vQwTISwXFXzDSlG0</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Smith, A.J</creator><creator>Scheven, B.A</creator><creator>Takahashi, Y</creator><creator>Ferracane, J.L</creator><creator>Shelton, R.M</creator><creator>Cooper, P.R</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Dentine as a bioactive extracellular matrix</title><author>Smith, A.J ; Scheven, B.A ; Takahashi, Y ; Ferracane, J.L ; Shelton, R.M ; Cooper, P.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-8169af7d27ba771c6ee7464d8709739dfd079da54e66b9bd445393ac2ca3df0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Advanced Basic Science</topic><topic>Bioactive</topic><topic>Cell Communication</topic><topic>Cytokines - physiology</topic><topic>Dental Pulp - physiology</topic><topic>Dentin - physiology</topic><topic>Dentine</topic><topic>Dentistry</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix - physiology</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Intercellular Signaling Peptides and Proteins - physiology</topic><topic>Neuropeptides - physiology</topic><topic>Odontoblasts - physiology</topic><topic>Regeneration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, A.J</creatorcontrib><creatorcontrib>Scheven, B.A</creatorcontrib><creatorcontrib>Takahashi, Y</creatorcontrib><creatorcontrib>Ferracane, J.L</creatorcontrib><creatorcontrib>Shelton, R.M</creatorcontrib><creatorcontrib>Cooper, P.R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, A.J</au><au>Scheven, B.A</au><au>Takahashi, Y</au><au>Ferracane, J.L</au><au>Shelton, R.M</au><au>Cooper, P.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dentine as a bioactive extracellular matrix</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>57</volume><issue>2</issue><spage>109</spage><epage>121</epage><pages>109-121</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>Abstract As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Nevertheless, dentine–pulp demonstrates strong regenerative potential which allows it to respond to disease and traumatic injury. Such responses are strongly influenced by cell–matrix interactions and modified by disease processes, including infection and inflammation. The identification of many bioactive molecules bound within dentine matrix has allowed their potential involvement in regenerative and other tissue responses to be better understood and new opportunities to be recognised for novel clinical therapies.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>21855856</pmid><doi>10.1016/j.archoralbio.2011.07.008</doi><tpages>13</tpages></addata></record> |
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| ispartof | Archives of oral biology, 2012-02, Vol.57 (2), p.109-121 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Advanced Basic Science Bioactive Cell Communication Cytokines - physiology Dental Pulp - physiology Dentin - physiology Dentine Dentistry Extracellular matrix Extracellular Matrix - physiology Humans Inflammation Intercellular Signaling Peptides and Proteins - physiology Neuropeptides - physiology Odontoblasts - physiology Regeneration |
| title | Dentine as a bioactive extracellular matrix |
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