The inflammatory response of keratinocytes and its modulation by vitamin D: The role of MAPK signaling pathways

The hormonal form of vitamin D, calcitriol, and its analogs are known for their beneficial effect in the treatment of inflammatory skin disorders. Keratinocytes play a role in epidermal inflammatory responses invoked by breeching of the epidermal barrier, by infectious agents and by infiltrating imm...

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Veröffentlicht in:	Journal of cellular physiology 2012-05, Vol.227 (5), p.2175-2183
Hauptverfasser:	Miodovnik, Mor, Koren, Ruth, Ziv, Esther, Ravid, Amiram
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism Cell Line Enzyme Inhibitors - metabolism Gene Expression - immunology Gene Expression Profiling Humans Intercellular Adhesion Molecule-1 - immunology Interferon Inducers - immunology Interleukin-8 - immunology Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - immunology MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - immunology Microarray Analysis Mitogen-Activated Protein Kinases - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Poly I-C - immunology Tumor Necrosis Factor-alpha - immunology Vitamin D - pharmacology Vitamins - pharmacology
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