Clinical Assessment of a Supplement of Pycnogenol® and l-arginine in Japanese Patients with Mild to Moderate Erectile Dysfunction
A double‐blind parallel group comparison design clinical study was conducted in Japanese patients with mild to moderate erectile dysfunction to investigate the efficacy of a supplement containing Pycnogenol® and L‐arginine. Subjects were instructed to take a supplement (Pycnogenol® 60 mg/day, l‐argi...
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| Veröffentlicht in: | Phytotherapy research 2012-02, Vol.26 (2), p.204-207 |
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| creator | Aoki, Hiromitsu Nagao, Junji Ueda, Taro Strong, Jeffry M. Schonlau, Frank Yu-Jing, Song Lu, Yan Horie, Shigeo |
| description | A double‐blind parallel group comparison design clinical study was conducted in Japanese patients with mild to moderate erectile dysfunction to investigate the efficacy of a supplement containing Pycnogenol® and L‐arginine. Subjects were instructed to take a supplement (Pycnogenol® 60 mg/day, l‐arginine 690 mg/day and aspartic acid 552 mg/day) or an identical placebo for 8 weeks, and the results were assessed using the five‐item erectile domain (IIEF‐5) of the International Index of Erectile Function. Additionally, blood biochemistry, urinalysis and salivary testosterone were measured. Eight weeks of supplement intake improved the total score of the IIEF‐5. In particular, a marked improvement was observed in ‘hardness of erection’ and ‘satisfaction with sexual intercourse’. A decrease in blood pressure, aspartate transaminase and γ‐glutamyl transpeptidase (γ‐GTP), and a slight increase in salivary testosterone were observed in the supplement group. No adverse reactions were observed during the study period. In conclusion, Pycnogenol® in combination with l‐arginine as a dietary supplement is effective and safe in Japanese patients with mild to moderate erectile dysfunction. Copyright © 2011 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.3462 |
| format | Article |
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Subjects were instructed to take a supplement (Pycnogenol® 60 mg/day, l‐arginine 690 mg/day and aspartic acid 552 mg/day) or an identical placebo for 8 weeks, and the results were assessed using the five‐item erectile domain (IIEF‐5) of the International Index of Erectile Function. Additionally, blood biochemistry, urinalysis and salivary testosterone were measured. Eight weeks of supplement intake improved the total score of the IIEF‐5. In particular, a marked improvement was observed in ‘hardness of erection’ and ‘satisfaction with sexual intercourse’. A decrease in blood pressure, aspartate transaminase and γ‐glutamyl transpeptidase (γ‐GTP), and a slight increase in salivary testosterone were observed in the supplement group. No adverse reactions were observed during the study period. In conclusion, Pycnogenol® in combination with l‐arginine as a dietary supplement is effective and safe in Japanese patients with mild to moderate erectile dysfunction. Copyright © 2011 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.3462</identifier><identifier>PMID: 21618639</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; Arginine - therapeutic use ; Asian Continental Ancestry Group ; Aspartate Aminotransferases - metabolism ; Biological and medical sciences ; Blood Pressure ; Double-Blind Method ; edicare ; erectile dysfunction ; Erectile Dysfunction - drug therapy ; Flavonoids - therapeutic use ; gamma-Glutamyltransferase - metabolism ; General pharmacology ; Humans ; Japanese ; l-arginine ; Male ; Medical sciences ; Middle Aged ; Patient Satisfaction ; Penile Erection ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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Res</addtitle><description>A double‐blind parallel group comparison design clinical study was conducted in Japanese patients with mild to moderate erectile dysfunction to investigate the efficacy of a supplement containing Pycnogenol® and L‐arginine. Subjects were instructed to take a supplement (Pycnogenol® 60 mg/day, l‐arginine 690 mg/day and aspartic acid 552 mg/day) or an identical placebo for 8 weeks, and the results were assessed using the five‐item erectile domain (IIEF‐5) of the International Index of Erectile Function. Additionally, blood biochemistry, urinalysis and salivary testosterone were measured. Eight weeks of supplement intake improved the total score of the IIEF‐5. In particular, a marked improvement was observed in ‘hardness of erection’ and ‘satisfaction with sexual intercourse’. A decrease in blood pressure, aspartate transaminase and γ‐glutamyl transpeptidase (γ‐GTP), and a slight increase in salivary testosterone were observed in the supplement group. No adverse reactions were observed during the study period. In conclusion, Pycnogenol® in combination with l‐arginine as a dietary supplement is effective and safe in Japanese patients with mild to moderate erectile dysfunction. Copyright © 2011 John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>Arginine - therapeutic use</subject><subject>Asian Continental Ancestry Group</subject><subject>Aspartate Aminotransferases - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Double-Blind Method</subject><subject>edicare</subject><subject>erectile dysfunction</subject><subject>Erectile Dysfunction - drug therapy</subject><subject>Flavonoids - therapeutic use</subject><subject>gamma-Glutamyltransferase - metabolism</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Japanese</subject><subject>l-arginine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Patient Satisfaction</subject><subject>Penile Erection</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>pycnogenol</subject><subject>testosterone</subject><subject>Testosterone - analysis</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MFu1DAQBuAIgei2IPEEyBcElxQ7jhPnWG1LAbWwokW7N2tiT4rB6wQ7UbtXHoiH4MnwarflxGk80jcz1p9lLxg9ZpQWb4cxHPOyKh5lM0abJmei5o-zGW0Ey0smVwfZYYzfKaVNQcun2UHBKiYr3syyX3NnvdXgyEmMGOMa_Uj6jgC5mobB4X2_2Gjf36Dv3Z_fBLwhLodwk0Y9EuvJRxjAY0SygNGmkUhu7fiNXFpnyNiTy95ggBHJWUA9WofkdBO7yad3759lTzpwEZ_v61H29d3Z9fx9fvH5_MP85CLXXMoiLzV02DLZida0wEvTGKmFEEUDABxK0VZtXTCQkmsuqEAjDTWGUsE5mBL5UfZ6t3cI_c8J46jWNmp0Lv28n6JqWC0Fr0qZ5Jud1KGPMWCnhmDXEDaKUbUNXKXA1TbwRF_ul07tGs0DvE84gVd7ADHF3AXw2sZ_TghW8Hrr8p27TfFs_ntQLa6_7A_vvY0j3j14CD9UVfNaqOWnc3VVL1eUrmq15H8B-Quo9Q</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>Aoki, Hiromitsu</creator><creator>Nagao, Junji</creator><creator>Ueda, Taro</creator><creator>Strong, Jeffry M.</creator><creator>Schonlau, Frank</creator><creator>Yu-Jing, Song</creator><creator>Lu, Yan</creator><creator>Horie, Shigeo</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201202</creationdate><title>Clinical Assessment of a Supplement of Pycnogenol® and l-arginine in Japanese Patients with Mild to Moderate Erectile Dysfunction</title><author>Aoki, Hiromitsu ; Nagao, Junji ; Ueda, Taro ; Strong, Jeffry M. ; Schonlau, Frank ; Yu-Jing, Song ; Lu, Yan ; Horie, Shigeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-4cafeb18f5bdba34d9d8c55529aaa3a45b6b721a883c3505ed8d0dd00533ad4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Arginine - therapeutic use</topic><topic>Asian Continental Ancestry Group</topic><topic>Aspartate Aminotransferases - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Double-Blind Method</topic><topic>edicare</topic><topic>erectile dysfunction</topic><topic>Erectile Dysfunction - drug therapy</topic><topic>Flavonoids - therapeutic use</topic><topic>gamma-Glutamyltransferase - metabolism</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Japanese</topic><topic>l-arginine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Patient Satisfaction</topic><topic>Penile Erection</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>pycnogenol</topic><topic>testosterone</topic><topic>Testosterone - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aoki, Hiromitsu</creatorcontrib><creatorcontrib>Nagao, Junji</creatorcontrib><creatorcontrib>Ueda, Taro</creatorcontrib><creatorcontrib>Strong, Jeffry M.</creatorcontrib><creatorcontrib>Schonlau, Frank</creatorcontrib><creatorcontrib>Yu-Jing, Song</creatorcontrib><creatorcontrib>Lu, Yan</creatorcontrib><creatorcontrib>Horie, Shigeo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aoki, Hiromitsu</au><au>Nagao, Junji</au><au>Ueda, Taro</au><au>Strong, Jeffry M.</au><au>Schonlau, Frank</au><au>Yu-Jing, Song</au><au>Lu, Yan</au><au>Horie, Shigeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Assessment of a Supplement of Pycnogenol® and l-arginine in Japanese Patients with Mild to Moderate Erectile Dysfunction</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2012-02</date><risdate>2012</risdate><volume>26</volume><issue>2</issue><spage>204</spage><epage>207</epage><pages>204-207</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>A double‐blind parallel group comparison design clinical study was conducted in Japanese patients with mild to moderate erectile dysfunction to investigate the efficacy of a supplement containing Pycnogenol® and L‐arginine. Subjects were instructed to take a supplement (Pycnogenol® 60 mg/day, l‐arginine 690 mg/day and aspartic acid 552 mg/day) or an identical placebo for 8 weeks, and the results were assessed using the five‐item erectile domain (IIEF‐5) of the International Index of Erectile Function. Additionally, blood biochemistry, urinalysis and salivary testosterone were measured. Eight weeks of supplement intake improved the total score of the IIEF‐5. In particular, a marked improvement was observed in ‘hardness of erection’ and ‘satisfaction with sexual intercourse’. A decrease in blood pressure, aspartate transaminase and γ‐glutamyl transpeptidase (γ‐GTP), and a slight increase in salivary testosterone were observed in the supplement group. No adverse reactions were observed during the study period. In conclusion, Pycnogenol® in combination with l‐arginine as a dietary supplement is effective and safe in Japanese patients with mild to moderate erectile dysfunction. Copyright © 2011 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>21618639</pmid><doi>10.1002/ptr.3462</doi><tpages>4</tpages></addata></record> |
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| ispartof | Phytotherapy research, 2012-02, Vol.26 (2), p.204-207 |
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| subjects | Adult Arginine - therapeutic use Asian Continental Ancestry Group Aspartate Aminotransferases - metabolism Biological and medical sciences Blood Pressure Double-Blind Method edicare erectile dysfunction Erectile Dysfunction - drug therapy Flavonoids - therapeutic use gamma-Glutamyltransferase - metabolism General pharmacology Humans Japanese l-arginine Male Medical sciences Middle Aged Patient Satisfaction Penile Erection Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments pycnogenol testosterone Testosterone - analysis |
| title | Clinical Assessment of a Supplement of Pycnogenol® and l-arginine in Japanese Patients with Mild to Moderate Erectile Dysfunction |
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